Abstract: Synthetic ?v?6 integrin ligands of Formula I having serum stability and affinity for integrin ?v?6, which is a receptor expressed in a variety of cell types, are described. The described ligands are useful for delivering cargo molecules, such as RNAi agents or other oligonucleotide-based compounds, to cells that express integrin ?v?6, and thereby facilitating the uptake of the cargo molecules into these cells. Compositions that include ?v?6 integrin ligands and methods of use are also described.

Abstract: Synthetic ?v?6 integrin ligands of Formula I having serum stability and affinity for integrin ?v?6, which is a receptor expressed in a variety of cell types, are described. The described ligands are useful for delivering cargo molecules, such as RNAi agents or other oligonucleotide-based compounds, to cells that express integrin ?v?6, and thereby facilitating the uptake of the cargo molecules into these cells. Compositions that include ?v?6 integrin ligands and methods of use are also described.

Abstract: Synthetic av?6 integrin ligands of Formula I having serum stability and affinity for integrin av?6, which is a receptor expressed in a variety of cell types, are described. The described ligands are useful for delivering cargo molecules, such as RNAi agents or other oligonucleotide-based compounds, to cells that express integrin av?6, and thereby facilitating the uptake of the cargo molecules into these cells. Compositions that include avB6 integrin ligands and methods of use are also described.

Abstract: A wireless network (1) comprises a base station (2) and sensor nodes (3). The base station (2) comprises a network interface (10), an application interface (11), topology control functions (12) a timer (13), and a buffer (14). Each sensor node (3) comprises a network interface (20), route control functions (21), processing functions (22), sensors (23), flood mechanism programs (24), tree mechanism programs (25), and data forwarding programs (26). The network operates by establishing a conventional routing tree from the sink node that is used when the network is stable. But when a sending node detects a node or link failure it dynamically switches to sending its data packets using a flooding mechanism, rather than waiting for the routing tree to be re-established. This reduces the latency for data delivery. Also, when flooding the data packets, it allows the packets to be flooded to nodes that are an equal number of hops from the sink node as the send node is from the sink node.

Abstract: A shielding device for shielding an electronic component (102) to be mounted on a printed circuit board (132). The shielding device exhibiting a top shielding (110) and a bottom shielding (120; 140; 160; 180) separable from each other, wherein the top shielding includes an electrically and/or magnetically conductive material and the bottom shielding is multilayered. The bottom shielding exhibits at least one electrically and/or magnetically conductive metal sheet layer (122; 162; 164) embedded between at least two insulating layers (126; 124) and includes at least two electrically conductive transmission lines (172; 174; 176) for conducting electric current to the electronic component. The top shielding and the conductive metal sheet layer are electrically isolated from the electronic component. The bottom shielding integrated into the printed circuit board and the top shielding and the bottom shielding designed such when they are attached to each other, they completely envelope the electronic component.

Abstract: The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.

Abstract: A shielding device for shielding an electronic component (102) to be mounted on a printed circuit board (132). The shielding device exhibiting a top shielding (110) and a bottom shielding (120; 140; 160; 180) separable from each other, wherein the top shielding includes an electrically and/or magnetically conductive material and the bottom shielding is multilayered. The bottom shielding exhibits at least one electrically and/or magnetically conductive metal sheet layer (122; 162; 164) embedded between at least two insulating layers (126; 124) and includes at least two electrically conductive transmission lines (172; 174; 176) for conducting electric current to the electronic component. The top shielding and the conductive metal sheet layer are electrically isolated from the electronic component. The bottom shielding integrated into the printed circuit board and the top shielding and the bottom shielding designed such when they are attached to each other, they completely envelope the electronic component.

Abstract: A wireless network (1) comprises a base station (2) and sensor nodes (3). The base station (2) comprises a network interface (10), an application interface (11), topology control functions (12) a timer (13), and a buffer (14). Each sensor node (3) comprises a network interface (20), route control functions (21), processing functions (22), sensors (23), flood mechanism programs (24), tree mechanism programs (25), and data forwarding programs (26). The network operates by establishing a conventional routing tree from the sink node that is used when the network is stable. But when a sending node detects a node or link failure it dynamically switches to sending its data packets using a flooding mechanism, rather than waiting for the routing tree to be reestablished. This reduces the latency for data delivery. Also, when flooding the data packets, it allows the packets to be flooded to nodes that are an equal number of hops from the sink node as the send node is from the sink node.