Patents by Inventor Jonathan Bentley

Jonathan Bentley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF SARM1
    Publication number: 20260152493
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: September 10, 2025
    Publication date: June 4, 2026
    Inventors: Jonathan BENTLEY, Todd BOSANAC, Andrew Simon BREARLEY, Rajesh DEVRAJ, Robert Owen HUGHES
  • Inhibitors of SARM1
    Patent number: 12624026
    Abstract: Compounds having a structure set forth in Formula I below are provided herein. Such compounds and methods disclosed herein, may be useful, for example, for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: May 12, 2026
    Assignee: DISARM THERAPEUTICS, INC.
    Inventors: Robert Owen Hughes, Rajesh Devraj, Todd Bosanac, Richard Andrew Jarjes-Pike, Andrew Simon Brearley, Jonathan Bentley
  • Inhibitors of SARM1
    Patent number: 12624025
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration. In some embodiments, the present disclosure provides certain compounds and/or compositions that are useful in medicine, and particularly for treating neurodegeneration (e.g., for reducing axonal degeneration). In some embodiments, the present disclosure provides compounds having a structure as set forth in Formula (I).
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: May 12, 2026
    Assignee: DISARM THERAPEUTICS, INC.
    Inventors: Robert Owen Hughes, Rajesh Devraj, Todd Bosanac, Richard Andrew Jarjes-Pike, Andrew Brearley, Jonathan Bentley
  • Inhibitors of SARM1
    Patent number: 12595252
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: April 7, 2026
    Assignee: DISARM THERAPEUTICS, INC.
    Inventors: Robert Owen Hughes, Rajesh Devraj, Todd Bosanac, Richard Andrew Jarjes-Pike, Andrew Simon Brearley, Jonathan Bentley, Shelley Anne Parrott, Sophie Catherine Cooper
  • Inhibitors of SARM1
    Patent number: 12448374
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: October 21, 2025
    Assignee: DISARM THERAPEUTICS, INC.
    Inventors: Robert Owen Hughes, Rajesh Devraj, Todd Bosanac, Richard Andrew Jarjes-Pike, Andrew Simon Brearley, Jonathan Bentley
  • Inhibitors of SARM1
    Patent number: 12441719
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: October 14, 2025
    Assignee: Disarm Therapeutics, Inc.
    Inventors: Jonathan Bentley, Todd Bosanac, Andrew Simon Brearley, Rajesh Devraj, Robert Owen Hughes
  • Indazole derivatives as inhibitors of SARM1
    Patent number: 12435084
    Abstract: The present disclosure provides compounds of formula (I) and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Grant
    Filed: April 7, 2021
    Date of Patent: October 7, 2025
    Assignee: Eli Lilly and Company
    Inventors: Jonathan Bentley, Shelley Anne Parrott, Andrew Simon Brearley, Todd Bosanac, Robert Owen Hughes, Rajesh Devraj
  • Inhibitors of SARM1
    Patent number: 12338238
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing neurodegenerative disease or axonal degeneration. The provided SARM1 inhibitors may reduce or inhibit binding of NAD+ by SARM1. Alternatively, provided SARM1 inhibitors bind to SARM1 within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARM1).
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: June 24, 2025
    Assignee: Disarm Therapeutics, Inc.
    Inventors: Robert Owen Hughes, Rajesh Devraj, Todd Bosanac, Richard Andrew Jarjes-Pike, Andrew Simon Brearley, Jonathan Bentley
  • Inhibitors of SARM1
    Patent number: 12331033
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Grant
    Filed: August 17, 2021
    Date of Patent: June 17, 2025
    Assignee: Disarm Therapeutics, Inc.
    Inventors: Jonathan Bentley, Todd Bosanac, Andrew Simon Brearley, Sophie Catherine Cooper, Rajesh Devraj, Robert Owen Hughes, Richard Andrew Jarjes-Pike, Frederic Jacques Marlin, Shelley Anne Parrott, Daniel Silva
  • INDAZOLE DERIVATIVES AS INHIBITORS OF SARM1
    Publication number: 20230286978
    Abstract: The present disclosure provides compounds of formula (I) and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: April 7, 2021
    Publication date: September 14, 2023
    Inventors: Jonathan Bentley, Shelley Anne Parrott, Andrew Simon Brearley, Todd Bosanac, Robert Owen Hughes, Rajesh Devraj
  • Inhibitors of SARM1
    Publication number: 20230008433
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: August 17, 2021
    Publication date: January 12, 2023
    Inventors: Jonathan BENTLEY, Todd BOSANAC, Andrew Simon BREARLEY, Sophie Catherine COOPER, Rajesh DEVRAJ, Robert Owen HUGHES, Richard Andrew JARJES-PIKE, Frederic Jacques MARLIN, Shelley Anne PARROTT, Daniel SILVA
  • INHIBITORS OF SARM1
    Publication number: 20220340546
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: June 12, 2020
    Publication date: October 27, 2022
    Inventors: Robert Owen HUGHES, Rajesh DEVRAJ, Todd BOSANAC, Richard Andrew JARJES-PIKE, Andrew Simon BREARLEY, Jonathan BENTLEY, Shelley Anne PARROTT, Sophie Catherine COOPER
  • INHIBITORS OF SARM1
    Publication number: 20220315568
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: September 11, 2020
    Publication date: October 6, 2022
    Inventors: Jonathan BENTLEY, Todd BOSANAC, Andrew Simon BREARLEY, Rajesh DEVRAJ, Robert Owen HUGHES
  • INHIBITORS OF SARM1
    Publication number: 20220242859
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration. In some embodiments, the present disclosure provides certain compounds and/or compositions that are useful in medicine, and particularly for treating neurodegeneration (e.g., for reducing axonal degeneration). In some embodiments, the present disclosure provides compounds having a structure as set forth in Formula (I).
    Type: Application
    Filed: June 5, 2020
    Publication date: August 4, 2022
    Inventors: Robert Owen HUGHES, Rajesh DEVRAJ, Todd BOSANAC, Richard Andrew JARJES-PIKE, Andrew BREARLEY, Jonathan BENTLEY
  • INHIBITORS OF SARM1
    Publication number: 20220194933
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.
    Type: Application
    Filed: June 6, 2019
    Publication date: June 23, 2022
    Inventors: Robert Owen Hughes, Rajesh Devraj, Todd Bosanac, Richard Andrew Jarjes-Pike, Andrew Simon Brearley, Jonathan Bentley
  • INHIBITORS OF SARM1
    Publication number: 20210261540
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing neurodegenerative disease or axonal degeneration. The provided SARM1 inhibitors may reduce or inhibit binding of NAD+ by SARM1. Alternatively, provided SARM1 inhibitors bind to SARM1 within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARM1).
    Type: Application
    Filed: June 6, 2019
    Publication date: August 26, 2021
    Inventors: Robert Owen Hughes, Rajesh Devraj, Todd Bosanac, Richard Andrew Jarjes-Pike, Andrew Simon Brearley, Jonathan Bentley
  • INHIBITORS OF SARM1
    Publication number: 20210261537
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARMI and/or treating and/or preventing axonal degeneration. Provided SARMI inhibitors reduce or inhibit binding of NAD+ by SARMI and SARMI inhibitors bind to SARMI within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARMI).
    Type: Application
    Filed: June 6, 2019
    Publication date: August 26, 2021
    Inventors: Robert Owen Hughes, Rajesh Devraj, Todd Bosanac, Richard Andrew Jarjes-Pike, Andrew Simon Brearley, Jonathan Bentley
  • Phenyl amino piperidine mTORC inhibitors and uses thereof
    Patent number: 10844013
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: November 24, 2020
    Assignee: NAVITOR PHARMACEUTICALS, INC.
    Inventors: David John O'Neill, Eddine Saiah, Seong Woo Anthony Kang, Andrew Brearley, Jonathan Bentley
  • PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF
    Publication number: 20200207716
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: August 7, 2019
    Publication date: July 2, 2020
    Inventors: David John O'Neill, Eddine Saiah, Seong Woo Anthony Kang, Andrew Brearley, Jonathan Bentley
  • PYRROLE mTORC INHIBITORS AND USES THEREOF
    Publication number: 20190389843
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: November 8, 2017
    Publication date: December 26, 2019
    Applicant: Navitor Pharmaceuticals, Inc.
    Inventors: David John O'Neill, Eddine Saiah, Seong Woo Anthony Kang, Andrew Brearley, Jonathan Bentley