Abstract: Disclosed herein is a targeted tumour-infiltrating bacteriophage. The bacteriophage is engineered to present an epidermal growth factor receptor (EGFR)-binding moiety on the bacteriophage cell surface. The EGFR-binding moiety is capable of binding the extracellular domain of the EGFR. Also disclosed are compositions, kits, methods and uses thereof. Also disclosed is a method of treating a tumour in a subject in need thereof, the method comprising: administering to the subject a composition comprising a plurality of bacteriophage engineered to present an epidermal growth factor receptor (EGFR)-binding moiety on the bacteriophage cell surface in a dose effective to treat the tumour, wherein the tumour is an EGFR-positive tumour and the EGFR-binding moiety is capable of binding an EGFR extracellular domain.

Abstract: In accordance with the present invention, novel compositions useful for the treatment of the cytopathogenic effects of an enveloped virus in mammals have been discovered by extraction and purification from the spikes of Prunella vulgaris. In particular, invention compositions comprise a lignin-carbohydrate complex as an active ingredient for inhibition of viral infection in a mammal. In accordance with an embodiment of the present invention, it has been discovered that invention compositions are effective agents for the prophylaxis and therapy in mammals of diseases caused by enveloped viruses, e.g., herpes simplex virus. Methods for producing invention compositions and uses therefor are also provided.