Patents by Inventor Jonathan Brunger

Jonathan Brunger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA-guided transcriptional regulation and methods of using the same for the treatment of back pain
    Patent number: 10954513
    Abstract: Described herein are compositions and methods for treatment and prevention of low back pain. The compositions include vectors comprising nucleotide sequences encoding one or more CRISPR-Cas system guide RNAs and a RNA-directed nuclease. The methods include modulating expression of a gene in a cell using said compositions, introducing a CRISPR-Cas system into a cell comprising one or more vectors comprising said compositions, inducing site-specific DNA cleavage in a cell, and treating a subject having lower back pain, and lower back pain caused by degenerative disc disease using the compositions disclosed herein.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: March 23, 2021
    Assignees: UNIVERSITY OF UTAH RESEARCH FOUNDATION, DUKE UNIVERSITY
    Inventors: Robert D. Bowles, Niloofar Farhang, Joshua Stover, Lori Setton, Farshid Guilak, Charles Gersbach, Jonathan Brunger
  • RNA-GUIDED TRANSCRIPTIONAL REGULATION AND METHODS OF USING THE SAME FOR THE TREATMENT OF BACK PAIN
    Publication number: 20180155715
    Abstract: Described herein are compositions and methods for treatment and prevention of low back pain. The compositions include vectors comprising nucleotide sequences encoding one or more CRISPR-Cas system guide RNAs and a RNA-directed nuclease. The methods include modulating expression of a gene in a cell using said compositions, introducing a CRISPR-Cas system into a cell comprising one or more vectors comprising said compositions, inducing site-specific DNA cleavage in a cell, and treating a subject having lower back pain, and lower back pain caused by degenerative disc disease using the compositions disclosed herein.
    Type: Application
    Filed: June 17, 2016
    Publication date: June 7, 2018
    Inventors: Robert D. Bowles, Niloofar Farhang, Joshua Stover, Lori Setton, Farshid Guilak, Charles Gersbach, Jonathan Brunger