Patents by Inventor Jonathan C. Makielski

Jonathan C. Makielski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid encoding sodium channel subunit
    Patent number: 7485455
    Abstract: The present invention discloses four groups of SCN5A variants that represent the most common SCN5A variants in humans. A specific mutation in one of the variants has been shown to display a different phenotype in relation to a human heart disease than other variants and known human sodium channel ? subunits with corresponding mutations. The present invention provides new tools to study mutations and to design or identify new diagnostic and treatment strategies or agents for sodium channel related diseases or conditions.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: February 3, 2009
    Assignees: Wisconsin Alumni Research Foundation, Mayo Clinic Health Solutions
    Inventors: Jonathan C. Makielski, Bin Ye, Michael J. Ackerman
  • SULFONYLUREA RECEPTOR SHORT FORMS FROM MITOCHONDRIA AND USES THEREOF
    Publication number: 20080293087
    Abstract: The present invention relates to isolated sulfonylurea receptor polynucleotides and polypeptides, as well as vectors and cells lines containing the polynucleotides and polypeptides. The present invention also relates to methods of using cell lines containing the polynucleotides and polypeptides to identify agents that are useful in ischemic preconditioning.
    Type: Application
    Filed: October 31, 2007
    Publication date: November 27, 2008
    Inventors: Jonathan C. Makielski, Nian-Qing Shi, Bin Ye
  • Sodium channel alpha subunit variants
    Publication number: 20040126787
    Abstract: The present invention discloses four groups of SCN5A variants that represent the most common SCN5A variants in humans. A specific mutation in one of the variants has been shown to display a different phenotype in relation to a human heart disease than other variants and known human sodium channel &agr; subunits with corresponding mutations. The present invention provides new tools to study mutations and to design or identify new diagnostic and treatment strategies or agents for sodium channel related diseases or conditions.
    Type: Application
    Filed: August 1, 2003
    Publication date: July 1, 2004
    Inventors: Jonathan C. Makielski, Bin Ye, Michael J. Ackerman
  • Sodium channel alpha subunits
    Publication number: 20030157600
    Abstract: The present invention discloses the cDNA sequence and the expressed amino acid sequence of a sodium channel &agr; subunit, termed hH1b. A specific mutation in hH1b has been shown to display a different phenotype in relation to a human heart disease than other known human sodium channel &agr; subunits with corresponding mutations. The present inventions provides new tools to design or identify new diagnostic and treatment strategies or agents for sodium channel related diseases or conditions.
    Type: Application
    Filed: February 12, 2002
    Publication date: August 21, 2003
    Inventors: Jonathan C. Makielski, Bin Ye