Patents by Inventor Jonathan C. Moore
Jonathan C. Moore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240068005Abstract: The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.Type: ApplicationFiled: July 14, 2023Publication date: February 29, 2024Inventors: Jeffrey C. Moore, Jack Liang, Jonathan Penfield, Jovana Nazor, Nikki Dellas, Vesna Mitchell, Da Duan, Iman Farasat, Agustina Rodriguez-Granillo, Grant Murphy, Nicholas Marshall
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Patent number: 10287611Abstract: This invention relates to biocatalysts for the efficient production of succinic acid and/or other products from renewable biological feedstocks. The biocatalysts have a very high efficiency for the growth-coupled production of succinic acid and/or other products from carbohydrate feed stocks as a result of both genetic manipulation and metabolic evolution. More specifically, certain biocatalysts of the present invention produce succinic acid at high titers and yields in mineral salts media during simple pH-controlled batch fermentation without the addition of any exogenous genetic material. The genetic manipulations of the present invention are concerned with energy-conserving strategies coupled with the elimination of alternative routes for NADH oxidation other than the routes for succinic acid production. The biocatalysts contain glucose-repressed gluconeogenic phosphoenolpyruvate carboxykinase (pck) derepressed by genetic modifications and a genetically-inactivated phosphotransferase system.Type: GrantFiled: May 6, 2015Date of Patent: May 14, 2019Assignee: University of Florida Research Foundation, IncorporatedInventors: Xueli Zhang, Kaemwich Jantama, Jonathan C. Moore, Laura R. Jarboe, Keelnatham T. Shanmugam, Lonnie O'Neal Ingram
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Publication number: 20150284746Abstract: This invention relates to the biocatalysts for the efficient production of succinic acid and/or other products from renewable biological feedstocks. The biocatalysts have a very high efficiency for the growth-coupled production of succinic acid and/or other products from carbohydrate feed stocks as a result of both genetic manipulations and metabolic evolution. More specifically, certain biocatalysts of the present invention produce succinic acid at high titers and yield in mineral salts media during simple pH-controlled, batch fermentation without the addition of any exogenous genetic material. The genetic manipulations of the present invention are concerned with the energy-conserving strategies coupled with the elimination of alternative routes for NADH oxidation other than the routes for succinic acid production. The biocatalysts contain glucose-repressed gluconeogenic phosphoenol pyruvate carboxykinase (pck) derepressed by genetic modifications and a genetically-inactivated phosphotransferase system.Type: ApplicationFiled: May 6, 2015Publication date: October 8, 2015Inventors: XUELI ZHANG, KAEMWICH JANTAMA, JONATHAN C. MOORE, LAURA R. JARBOE, KEELNATHAM T. SHANMUGAM, LONNIE O'NEAL INGRAM
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Patent number: 8691539Abstract: Genetically engineered microorganisms have been constructed to produce succinate and malate in mineral salt media in pH-controlled batch fermentations without the addition of plasmids or foreign genes. The subject invention also provides methods of producing succinate and malate comprising the culture of genetically modified microorganisms.Type: GrantFiled: March 19, 2008Date of Patent: April 8, 2014Assignee: University of Florida Research Foundation, Inc.Inventors: Kaemwich Jantama, Mark John Haupt, Xueli Zhang, Jonathan C. Moore, Keelnatham T. Shanmugam, Lonnie O'Neal Ingram
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Patent number: 8426191Abstract: The present invention provides derivatives of Escherichia coli constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.Type: GrantFiled: December 7, 2009Date of Patent: April 23, 2013Assignee: University of Florida Research Foundation, Inc.Inventors: Shengde Zhou, Lonnie O'Neal Ingram, Keelnatham T. Shanmugam, Lorraine Yomano, Tammy B. Grabar, Jonathan C. Moore
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Publication number: 20120058530Abstract: This invention relates to the biocatalysts for the efficient production of succinic acid and/or other products from renewable biological feedstocks. The biocatalysts have a very high efficiency for the growth-coupled production of succinic acid and/or other products from carbohydrate feed stocks as a result of both genetic manipulations and metabolic evolution. More specifically, certain biocatalysts of the present invention produce succinic acid at high titers and yield in mineral salts media during simple pH-controlled, batch fermentation without the addition of any exogenous genetic material. The genetic manipulations of the present invention are concerned with the energy-conserving strategies coupled with the elimination of alternative routes for NADH oxidation other than the routes for succinic acid production. The biocatalysts contain glucose-repressed gluconeogenic phosphoenol pyruvate carboxykinase (pck) depressed by genetic modifications and a genetically-inactivated phosphotransferase system.Type: ApplicationFiled: April 2, 2010Publication date: March 8, 2012Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC.Inventors: Xueli Zhang, Kaemwich Jantama, Jonathan C. Moore, Laura R. Jarboe, Keelnatham T. Shanmugam, Lonnie O'Neal Ingram
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Patent number: 8124259Abstract: A microbial fuel cell (100) includes an anode compartment (110) including an anode (115) and anolyte (120). The anolyte (120) comprises a plurality of in-vivo cells (125) mixed with a plurality of electrically conducting nano or micro-scale fibers (128), wherein at least a portion of the plurality of electrically conducting fibers (128) are in electrical contact with a surface of the anode (115). A cathode compartment (140) includes a cathode (145) and a catholyte (150). A cation-exchange membrane (155) is disposed between the anode compartment (110) and the cathode compartment (140).Type: GrantFiled: October 20, 2005Date of Patent: February 28, 2012Assignee: University of Florida Research Foundation, Inc.Inventors: Andrew G. Rinzler, Lonnie O'Neal Ingram, Keelnatham T. Shanmugam, Jonathan C. Moore, Zhuangchun Wu
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Publication number: 20100203602Abstract: The present invention provides derivatives of Escherichia coli constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.Type: ApplicationFiled: December 7, 2009Publication date: August 12, 2010Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.Inventors: SHENGDE ZHOU, LONNIE O'NEAL INGRAM, KEELNATHAM T. SHANMUGAM, LORRAINE YOMANO, TAMMY B. GRABAR, JONATHAN C. MOORE
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Publication number: 20100184171Abstract: Genetically engineered microorganisms have been constructed to produce succinate and malate in mineral salt media in pH-controlled batch fermentations without the addition of plasmids or foreign genes. The subject invention also provides methods of producing succinate and malate comprising the culture of genetically modified microorganisms.Type: ApplicationFiled: March 19, 2008Publication date: July 22, 2010Inventors: Kaemwich Jantama, Mark John Haupt, Xueli Zhang, Jonathan C. Moore, Keelnatham T. Shanmugam, Lonnie O'Neal Ingram
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Patent number: 7629162Abstract: The present invention provides derivatives of ethanologenic Escherichia coli K011 constructed for the production of lactic acid. The transformed E. coli of the invention are prepared by deleting the genes that encode competing pathways followed by a growth-based selection for mutants with improved performance. These transformed E. coli are useful for providing an increased supply of lactic acid for use in food and industrial applications.Type: GrantFiled: August 8, 2006Date of Patent: December 8, 2009Assignee: University of Florida Research Foundation, Inc.Inventors: Shengde Zhou, Lonnie O'Neal Ingram, Keelnatham T. Shanmugam, Lorraine Yomano, Tammy B. Grabar, Jonathan C. Moore
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Publication number: 20080261083Abstract: A microbial fuel cell (100) includes an anode compartment (110) including an anode (115) and anolyte (120). The anolyte (120) comprises a plurality of in-vivo cells (125) mixed with a plurality of electrically conducting nano or micro-scale fibers (128), wherein at least a portion of the plurality of electrically conducting fibers (128) are in electrical contact with a surface of the anode (115). A cathode compartment (140) includes a cathode (145) and a catholyte (150). A cation-exchange membrane (155) is disposed between the anode compartment (110) and the cathode compartment (140).Type: ApplicationFiled: October 20, 2005Publication date: October 23, 2008Applicant: University of Florida Research Foundation, Inc.Inventors: Andrew G. Rinzler, Lonnie O'Neal Ingram, Keelnatham T. Shanmugam, Jonathan C. Moore, Zhuangchun Wu