Patents by Inventor Jonathan C. R. Jones

Jonathan C. R. Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and materials for making and using laminin-5
    Patent number: 6294356
    Abstract: The invention provides two forms of laminin-5. One form comprising unprocessed &agr;3 subunits promotes the migration of epithelial cells. The other form comprising plasmin-cleaved &agr;3 subunits promotes the formation of hemidesmosomes. The invention further provides methods of making and using the two forms of laminin-5 and products comprising the two forms of laminin-5.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: September 25, 2001
    Assignee: Northwestern University
    Inventors: Jonathan C. R. Jones, M. Sharon Stack, Lawrence E. Goldfinger
  • Human epithelial cell matrix and uses therefor
    Patent number: 5935853
    Abstract: A method of growing epithelial cells by contacting the cells with the extracellular matrix deposited or secreted by human MCF-10A mammary epithelial cells. The MCF-10A matrix stimulates cell attachment and hemidesmosome formation in epithelial cells contacted therewith. The invention also encompasses the isolated or purified MCF-10A matrix, compositions comprising the matrix, and shaped articles coated with the matrix.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: August 10, 1999
    Assignee: Northwestern University
    Inventors: Jonathan C. R. Jones, Stephanie Stahl, Sigmund A. Weitzman
  • Human epithelial cell matrix and uses therefor
    Patent number: 5770448
    Abstract: A method of growing epithelial cells by contacting the cells with the extracellular matrix deposited or secreted by human MCF-10A mammary epithelial cells. The MCF-10A matrix stimulates cell attachment and hemidesmosome formation in epithelial cells contacted therewith. The invention also encompasses the isolated or purified MCF-10A matrix, compositions comprising the matrix, and shaped articles coated with the matrix.
    Type: Grant
    Filed: March 29, 1996
    Date of Patent: June 23, 1998
    Assignee: Northwestern University
    Inventors: Jonathan C. R. Jones, Stephanie Stahl, Sigmund A. Weitzman
  • Cell matrix stimulated attachment and hemidesmosome assembly
    Patent number: 5541106
    Abstract: A method for growing epithelial cells in vitro is described, The matrix secreted by 804G rat bladder carcinoma cells is able to stimulate cell attachment and hemidesmosome formation in cells grown on the matrix, Human epithelial cells grown on the 804G matrix are able to produce normal hemidesmosomes and attach to their growing substrate.
    Type: Grant
    Filed: October 14, 1994
    Date of Patent: July 30, 1996
    Assignee: Desmos, Inc.
    Inventor: Jonathan C. R. Jones
  • Growth of pancreatic islet-like cell clusters
    Patent number: 5510263
    Abstract: A method for growing endocrine precursor cells in vitro, such as pancreatic islet precursors, by culturing such cells in the presence or absence of cell matrix proteins capable of promoting hemidesmosome formation, such as those produced by the rat bladder carcinoma cell line 804G.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: April 23, 1996
    Assignee: Desmos, Inc.
    Inventors: Vito Quaranta, Jonathan C. R. Jones
  • Cellular attachment to trans-epithelial appliances
    Patent number: RE36844
    Abstract: A trans-epithelial appliance having a hemidesmosome formation-inducing protein composition derived from rat bladder carcinoma cells deposited thereon. This composition stimulates cell attachment and may be either the cell matrix or a soluble factor isolated from the conditioned medium. The appliance will be useful for diminishing inflammation and/or infection at the site of entry of the appliance. The appliance may also be used to stimulate gum junctional epithelium adhesion in the treatment of gingivitis and periodontitis. The composition may be used to maintain tissues ex vivo.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: August 29, 2000
    Assignee: Desmos Incorporated
    Inventors: Jonathan C. R. Jones, Vito Quaranta, Richard Tamura