Abstract: The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.

Abstract: A method for virtually representing human body poses includes receiving positioning data detailing parameters of one or more body parts of a human user based at least in part on input from one or more sensors. One or more mapping constraints are maintained that relate a model articulated representation to a target articulated representation. A model pose of the model articulated representation and a target pose of the target articulated representation are concurrently estimated based at least in part on the positioning data and the one or more mapping constraints. The previously-trained pose optimization machine is trained with training positioning data having ground truth labels for the model articulated representation. The target articulated representation is output for display with the target pose as a virtual representation of the human user.

Abstract: A method for virtually representing human body poses includes receiving positioning data detailing parameters of one or more body parts of a human user based at least in part on input from one or more sensors. One or more mapping constraints are maintained that relate a model articulated representation to a target articulated representation. A model pose of the model articulated representation and a target pose of the target articulated representation are concurrently estimated based at least in part on the positioning data and the one or more mapping constraints. The previously-trained pose optimization machine is trained with training positioning data having ground truth labels for the model articulated representation. The target articulated representation is output for display with the target pose as a virtual representation of the human user.

Abstract: A method for predicting the pose of an articulated object includes receiving spatial information for n joints of the articulated object. The spatial information for the n joints is passed to a machine learning model previously trained to receive spatial information for n+m joints as input, wherein m>=1. From the machine learning model, a pose prediction for the articulated object is received as output based at least on the spatial information for the n joints, and without spatial information for the m joints.

Abstract: One example provides a system for reading birefringent data. The system comprises one or more light sources, a first polarization state generator positioned to generate first polarized light from light of a first wavelength band output by the one or more light sources, a second polarization state generator positioned to generate second polarized light from light of a second wavelength band output by the one or light sources, an image sensor configured to acquire an image of the sample region via the first polarized light and the second polarized light, a polarization state analyzer disposed between the sample region and the image sensor, a first bandpass filter configured to pass light of the first wavelength band onto the image sensor, and a second bandpass filter configured to pass light of the second wavelength band onto the image sensor.

Abstract: One example provides a system for reading birefringent data. The system comprises one or more light sources, a first polarization state generator positioned to generate first polarized light from light of a first wavelength band output by the one or more light sources, a second polarization state generator positioned to generate second polarized light from light of a second wavelength band output by the one or light sources, an image sensor configured to acquire an image of the sample region via the first polarized light and the second polarized light, a polarization state analyzer disposed between the sample region and the image sensor, a first bandpass filter configured to pass light of the first wavelength band onto the image sensor, and a second bandpass filter configured to pass light of the second wavelength band onto the image sensor.

Abstract: One example provides a system for reading birefringent data. The system comprises one or more light sources, a first polarization state generator positioned to generate first polarized light from light of a first wavelength band output by the one or more light sources, a second polarization state generator positioned to generate second polarized light from light of a second wavelength band output by the one or light sources, an image sensor configured to acquire an image of the sample region via the first polarized light and the second polarized light, a polarization state analyzer disposed between the sample region and the image sensor, a first bandpass filter configured to pass light of the first wavelength band onto the image sensor, and a second bandpass filter configured to pass light of the second wavelength band onto the image sensor.

Abstract: One example provides a system for reading birefringent data. The system comprises one or more light sources, a first polarization state generator positioned to generate first polarized light from light of a first wavelength band output by the one or more light sources, a second polarization state generator positioned to generate second polarized light from light of a second wavelength band output by the one or light sources, an image sensor configured to acquire an image of the sample region via the first polarized light and the second polarized light, a polarization state analyzer disposed between the sample region and the image sensor, a first bandpass filter configured to pass light of the first wavelength band onto the image sensor, and a second bandpass filter configured to pass light of the second wavelength band onto the image sensor.

Abstract: A method for migrating a nickname cache via a migration manager is described. The method includes the migration manager locating where the nickname cache is stored and locating where the nickname cache is to be migrated. Once the source and target devices are located, the migration manager can generate any necessary transformations so that the data migrated from the source device to the target device is compatible. The nickname cache can then be extracted from the source device, transformed and stored into the nickname cache of the target device.

Abstract: The present invention concerns a machine for martial arts training that simulates sparring with a live partner and provides a safe tool for body hardening. More specifically, the machine is a vertical alignment of three independently rotatable Alpha Bodies having detachable arms, a weighted base, and bearing interfaces, where each Alpha Body may rotate to initiate strikes via programmable servo motors. The present invention facilitates martial arts offensive strikes and defensive moves, which safely promotes the formation of calcium deposits and scar tissue about key nerve areas to give the body a hardened feel.

Abstract: Systems and methods for detecting and evaluating data migrations over a network are described. More specifically, a Migration Manager is provided to detect data migrations over the network and determine whether the performance of the data migration is satisfactory. In situations where the current data migration is too slow, the Migration Manager may postpone or reschedule the data migration for another time.

Abstract: The present invention concerns a machine for martial arts training that simulates sparring with a live partner and provides a safe tool for body hardening. More specifically, the machine is a vertical alignment of three independently rotatable Alpha Bodies having detachable arms, a weighted base, and bearing interfaces, where each Alpha Body rotates when met by force from a user or may rotate to initiate strikes via programmable servo motors. The present invention facilitates martial arts offensive strikes and defensive moves, which safely promotes the formation of calcium deposits and scar tissue about key nerve areas to give the body a hardened feel.

Abstract: A method for migrating a nickname cache via a migration manager is described. The method includes the migration manager locating where the nickname cache is stored and locating where the nickname cache is to be migrated. Once the source and target devices are located, the migration manager can generate any necessary transformations so that the data migrated from the source device to the target device is compatible. The nickname cache can then be extracted from the source device, transformed and stored into the nickname cache of the target device.

Abstract: Systems and methods for detecting and evaluating data migrations over a network are described. More specifically, a Migration Manager is provided to detect data migrations over the network and determine whether the performance of the data migration is satisfactory. In situations where the current data migration is too slow, the Migration Manager may postpone or reschedule the data migration for another time.

Abstract: The present invention concerns a machine for martial arts training that simulates sparring with a live partner and provides a safe tool for body hardening. The machine is a vertical alignment of three independently rotatable alpha bodies having arms and a weighted base, where each alpha body rotates when met by force from a user. The machine facilitates martial arts offensive strikes and defensive moves, which safely promotes the formation of calcium deposits and scar tissue about key nerve areas to give the body a hardened feel.

Abstract: A method and system of monitoring an object (e.g., for change in configuration of a person) includes projecting a radiation pattern onto the object; recording at a first time first image data representing a portion of the projected radiation pattern on the object, the first image data representative of a three dimensional configuration of the object at the first time; recording at a second time second image data representing a portion of the projected pattern of radiation on the object, the second image data representative of a three dimensional configuration of the object at the second time; and processing the first and second image data to generate differential data representative of a change in the configuration of the object between the first and second times.

Abstract: A method and system of monitoring an object (e.g., for change in configuration of a person) includes projecting a radiation pattern onto the object; recording at a first time first image data representing a portion of the projected radiation pattern on the object, the first image data representative of a three dimensional configuration of the object at the first time; recording at a second time second image data representing a portion of the projected pattern of radiation on the object, the second image data representative of a three dimensional configuration of the object at the second time; and processing the first and second image data to generate differential data representative of a change in the configuration of the object between the first and second times.

Abstract: A method and system of monitoring an object (e.g., for change in configuration of a person) includes projecting a radiation pattern onto the object; recording at a first time first image data representing a portion of the projected radiation pattern on the object, the first image data representative of a three dimensional configuration of the object at the first time; recording at a second time second image data representing a portion of the projected pattern of radiation on the object, the second image data representative of a three dimensional configuration of the object at the second time; and processing the first and second image data to generate differential data representative of a change in the configuration of the object between the first and second times.

Abstract: A method and system of monitoring an object (e.g., for change in configuration of a person) includes projecting a radiation pattern onto the object; recording at a first time first image data representing a portion of the projected radiation pattern on the object, the first image data representative of a three dimensional configuration of the object at the first time; recording at a second time second image data representing a portion of the projected pattern of radiation on the object, the second image data representative of a three dimensional configuration of the object at the second time; and processing the first and second image data to generate differential data representative of a change in the configuration of the object between the first and second times.