Abstract: Techniques for disintermediating a network path between a source and a destination are described. In an example, the source sends a first packet destined to a destination. A network node on the network path between the source and the destination performs a network operation on this packet and generates a set of instructions indicating the network operation and parameters used for performing the network operations. This set of instructions is sent to the source as a flow update. When the source needs to send a second packet to the destination, the source applies the instructions to the second packet. As such, a similar network operation is performed on the second packet at the source, thereby avoiding the need to send the second packet on the same network path that includes the network node. Accordingly, the second packet is sent on a different network path that bypasses the network node.

Abstract: Techniques for disintermediating a network path between a source and a destination are described. In an example, the source sends a first packet destined to a destination. A network node on the network path between the source and the destination performs a network operation on this packet and generates a set of instructions indicating the network operation and parameters used for performing the network operations. This set of instructions is sent to the source as a flow update. When the source needs to send a second packet to the destination, the source applies the instructions to the second packet. As such, a similar network operation is performed on the second packet at the source, thereby avoiding the need to send the second packet on the same network path that includes the network node. Accordingly, the second packet is sent on a different network path that bypasses the network node.

Abstract: Techniques for disintermediating a network path between a source and a destination are described. In an example, the source sends a first packet destined to a destination. A network node on the network path between the source and the destination performs a network operation on this packet and generates a set of instructions indicating the network operation and parameters used for performing the network operations. This set of instructions is sent to the source as a flow update. When the source needs to send a second packet to the destination, the source applies the instructions to the second packet. As such, a similar network operation is performed on the second packet at the source, thereby avoiding the need to send the second packet on the same network path that includes the network node. Accordingly, the second packet is sent on a different network path that bypasses the network node.

Abstract: The present disclosure provides bioorthogonal linkers and reagents, including trans-cyclooctene (“TCO”)- and tetrazine (“Tz”)-containing compounds. In a general aspect, the present disclosure provides reagents, conjugates, and bioactive molecules containing a trans-cyclooctene (“TCO”) fragment. Examples of TCO fragments include: Formulae (I) and (II).

Abstract: This present application relates to fluorescent tetrazine-containing compounds consisting of a single pi-system. For example, a compound of Formula (I): F-L-Tz or a salt thereof, wherein: F is a fluorophore, L is a conjugated linker, and Tz is a substituted or unsubstituted tetrazine; wherein the linker bridges the Tz and F moieties in a single conjugated pi-system. Also provided herein are methods of using the compounds provided herein for biomedical imaging.

Abstract: This present application relates to fluorescent tetrazine-containing compounds consisting of a single pi-system. For example, a compound of Formula (I): or a salt thereof, wherein: F is a fluorophore, L is a conjugated linker, and Tz is a substituted or unsubstituted tetrazine; wherein the linker bridges the Tz and F moieties in a single conjugated pi-system. Also provided herein are methods of using the compounds provided herein for biomedical imaging.

Abstract: This present application relates to fluorescent tetrazine-containing compounds consisting of a single pi-system. For example, a compound of Formula (I): or a salt thereof, wherein: F is a fluorophore, L is a conjugated linker, and Tz is a substituted or unsubstituted tetrazine; wherein the linker bridges the Tz and F moieties in a single conjugated pi-system. Also provided herein are methods of using the compounds provided herein for biomedical imaging.

Abstract: The present invention relates to novel recombinant autonomous parvovirus vectors, novel recombinant virus particles, and novel gene delivery vehicles that can be used to selectively target heterologous nucleic acid sequences to desired cell types and to selectively express such sequences in such desired cell types. Recombinant autonomous parvovirus gene delivery vehicles are particularly advantageous for transient gene therapy, and are especially well-suited to treat diseases in which there is rapid cell growth, such as cancer. Also included is the use of recombinant vectors of the present invention to produce RNA and protein products in cell culture.