Patents by Inventor Jonathan Caudill

Jonathan Caudill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutically acceptable inorganic and organic salts of 5-methylpyrazine-2-carboxylic acid-4-oxide
    Patent number: 7153965
    Abstract: Methods for the preparation of pharmaceutically acceptable organic or inorganic salts of 5-methylpyrazinecarboxylic acid-4-oxide esters including tris(hydroxymethyl)aminomethanol, N,N-dimethylethanolamine, N-methyl-D-glucamine, L-Lysine, L-arginine, Na, K, Ca and Mg. The esters of 5-methylpyrazinecarboxylic acid-4-oxide are oxidized in aqueous hydrogen peroxide at a pH of 2.5 to 7 in the presence of a catalyst selected from the group consisting of sodium tungstate, tungstic acid and ammonium heptamolybdate. The salts are formed by saponification of the esters followed by alcohol precipitation, or by reaction with a metal trimethylsilanoate, or by the reaction of organic bases with the saponified acids.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: December 26, 2006
    Assignee: ISP Investments Inc.
    Inventors: Mark Cooney, Jonathan Caudill, Satish C. Nigam
  • Method for the preparation of 5-methylpyrazine-2-carboxylic acid-4-oxide and its salts
    Patent number: 7151178
    Abstract: Methods for the preparation of pharmaceutically acceptable salts of 5-methylpyrazine-carboxylic acid-4-oxide by using the oxidizing agent OXONE® for the N-oxidation of C1-4 methylpyrazinecarboxylic acid esters. The pharmaceutically acceptable salts are then formed by the saponification of the esters followed by alcohol precipitation.
    Type: Grant
    Filed: April 22, 2004
    Date of Patent: December 19, 2006
    Assignee: ISP Investments Inc.
    Inventors: Jonathan Caudill, Mark Cooney, Satish C. Nigam
  • Pharmaceutically acceptable inorganic and organic salts of 5-methylpyrazine-2-carboxylic acid-4-oxide
    Publication number: 20050261312
    Abstract: Methods for the preparation of pharmaceutically acceptable organic or inorganic salts of 5-methylpyrazinecarboxylic acid-4-oxide esters including tris(hydroxymethyl)aminomethanol, N,N-dimethylethanolamine, N-methyl-D-glucamine, L-Lysine, L-arginine, Na, K, Ca and Mg. The esters of 5-methylpyrazinecarboxylic acid-4-oxide are oxidized in aqueous hydrogen peroxide at a pH of 2.5 to 7 in the presence of a catalyst selected from the group consisting of sodium tungstate, tungstic acid and ammonium heptamolybdate. The salts are formed by saponification of the esters followed by alcohol precipitation, or by reaction with a metal trimethylsilanoate, or by the reaction of organic bases with the saponified acids.
    Type: Application
    Filed: May 18, 2004
    Publication date: November 24, 2005
    Inventors: Mark Cooney, Jonathan Caudill, Satish Nigam
  • Method for the preparation of 5-methylpyrazine-2-carboxylic acid-4-oxide and its salts
    Publication number: 20050239803
    Abstract: Methods for the preparation of pharmaceutically acceptable salts of 5-methylpyrazine-carboxylic acid-4-oxide by using the oxidizing agent OXONE® for the N-oxidation of C1-4 methylpyrazinecarboxylic acid esters. The pharmaceutically acceptable salts are then formed by the saponification of the esters followed by alcohol precipitation.
    Type: Application
    Filed: April 22, 2004
    Publication date: October 27, 2005
    Inventors: Jonathan Caudill, Mark Cooney, Satish Nigam