Patents by Inventor JONATHAN CHARLES PAUL STEELE

JONATHAN CHARLES PAUL STEELE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biocatalytic techniques
    Patent number: 11891642
    Abstract: A method for the use of a cytochrome P450 enzyme comprising any of SEQ ID NO: 1-118, or mutants thereof or a variant enzyme having at least 70% identity thereto and having CYP450 activity, for the hydroxylation and or dealkylation of an organic compound.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: February 6, 2024
    Assignee: HYPHA DISCOVERY LIMITED
    Inventors: Jonathan Charles Paul Steele, Antonio De Riso, Francesco Falcioni, Richard Kerry Phipps, Stephen Keith Wrigley, Emily Jade Hopkins, Aksana Rimu Khan, Tetsuo Kokubun, Kinga Linda Nytko, Vincent Poon, Sebastian Schulz, John Maxim Ward, Mariacristina Bawn
  • Hydroxylation techniques
    Patent number: 11618906
    Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 110, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound, wherein the amino acid residue at position 291 is not threonine.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: April 4, 2023
    Assignee: HYPHA DISCOVERY LTD.
    Inventors: Jonathan Charles Paul Steele, Antonio De Riso, Francesco Falcioni, Richard Kerry Phipps, Stephen Keith Wrigley, Kinga Linda Nytko, Vincent Poon, Sebastian Schulz, John Maxim Ward, Mariacristina Bawn
  • BIOCATALYTIC TECHNIQUES
    Publication number: 20230040326
    Abstract: The present invention relates to a cytochrome P450 enzyme comprising the amino acid sequence set forth in SEQ ID NO: 3, or a variant thereof having an amino acid sequence having at least 95% identity thereto and having CYP450 activity. The cytochrome P450 enzyme provided herein was isolated from Streptomyces eurythermus NRRL 2539 and has a wide substrate range and high activity, and may be used to oxidate organic compounds.
    Type: Application
    Filed: November 23, 2020
    Publication date: February 9, 2023
    Applicant: HYPHA DISCOVERY LIMITED
    Inventors: Jonathan Charles Paul STEELE, Antonio DE RISO, Francesco FALCIONI, Stephen Keith WRIGLEY, Emily Jade HOPKINS, Aksana Rimu KHAN, Kinga Linda NYTKO, Vincent POON, John Maxim WARD, Sebastian SCHULZ
  • Hydroxylation of branched aliphatic or aromatic substrates employing the amycolatopsis lurida cytochrome P450
    Patent number: 11384371
    Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 3, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: July 12, 2022
    Assignee: HYPHA DISCOVERY LIMITED
    Inventors: Jonathan Charles Paul Steele, Antonio De Riso, Headley St Edward Williams, Richard Kerry Phipps, Stephen Keith Wrigley, Kinga Linda Nytko, Vincent Poon, Sebastian Schulz, John Maxim Ward
  • BIOCATALYTIC TECHNIQUES
    Publication number: 20220025416
    Abstract: A method for the use of a cytochrome P450 enzyme comprising any of SEQ ID NO: 1-118, or mutants thereof or a variant enzyme having at least 70% identity thereto and having CYP450 activity, for the hydroxylation and or dealkylation of an organic compound.
    Type: Application
    Filed: November 26, 2019
    Publication date: January 27, 2022
    Applicant: HYPHA DISCOVERY LIMITED
    Inventors: Jonathan Charles Paul STEELE, Antonio DE RISO, Francesco FALCIONI, Richard Kerry PHIPPS, Stephen Keith WRIGLEY, Emily Jade HOPKINS, Aksana Rimu KHAN, Tetsuo KOKUBUN, Kinga Linda NYTKO, Vincent POON, Sebastian SCHULZ, John Maxim WARD, Mariacristina BAWN
  • HYDROXYLATION TECHNIQUES
    Publication number: 20210230642
    Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 110, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound, wherein the amino acid residue at position 291 is not threonine.
    Type: Application
    Filed: May 14, 2019
    Publication date: July 29, 2021
    Applicant: HYPHA DISCOVERY LTD.
    Inventors: Jonathan Charles Paul STEELE, Antonio DE RISO, Francesco FALCIONI, Richard Kerry PHIPPS, Stephen Keith WRIGLEY, Kinga Linda NYTKO, Vincent POON, Sebastian SCHULZ, John Maxim WARD, Mariacristina BAWN
  • HYDROXYLATION OF BRANCHED ALIPHATIC OR AROMATIC SUBSTRATES EMPLOYING THE AMYCOLATOPSIS LURIDA CYTOCHROME P450
    Publication number: 20190367957
    Abstract: The use of a cytochrome P-450 enzyme comprising SEQ ID NO: 3, or a variant enzyme having at least 70% identity thereto and having CYP-450 activity, for the hydroxylation of an organic compound.
    Type: Application
    Filed: November 15, 2017
    Publication date: December 5, 2019
    Inventors: JONATHAN CHARLES PAUL STEELE, ANTONIO DE RISO, HEADLEY ST EDWARD WILLIAMS, RICHARD KERRY PHIPPS, STEPHEN KEITH WRIGLEY, KINGA LINDA NYTKO, VINCENT POON, SEBASTIAN SCHULZ, JOHN MAXIM WARD