Patents by Inventor Jonathan Cheng

Jonathan Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250101504
    Abstract: Provided herein are methods for determining the mislocalization of an analyte by capturing the analyte on an array and measuring the mislocalization distance.
    Type: Application
    Filed: December 11, 2024
    Publication date: March 27, 2025
    Inventors: Monica Nagendran, Jonathan Cheng, Eswar Prasad Ramachandran Iyer
  • Patent number: 12203134
    Abstract: Provided herein are methods for determining the mislocalization of an analyte by capturing the analyte on an array and measuring the mislocalization distance.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: January 21, 2025
    Assignee: 10x Genomics, Inc.
    Inventors: Monica Nagendran, Jonathan Cheng, Eswar Prasad Ramachandran Iyer
  • Publication number: 20240288442
    Abstract: Methods for identifying a cell population secreting a biomolecule with desirable attributes are disclosed. The desirable attributes can include, for example, quantity and quality (e.g., minimal aggregation and/or desired configuration). Cell populations identified by the disclosed methods are more likely to successfully scale during production. The methods can include assessing multiple domains/binding sites of a complex biomolecule and/or the formation of aggregates by the biomolecules. Methods of assessing a secretion level for biomolecules having a wide range of molecular weights and method for enhancing loading of cells into chambers of a microfluidic device.
    Type: Application
    Filed: September 28, 2023
    Publication date: August 29, 2024
    Applicant: BERKELEY LIGHTS, INC.
    Inventors: Phillip J. M. ELMS, Preston Lock NG, Jonathan CHENG, Nathan J. VER HEUL, Jason King Mckenzie YEE, Hariharasudhan CHIRRA DINAKAR, Renee Lynn TOBIAS, Eric K. SACKMANN, Wesley Arthur ZINK, Hector D. NEIRA-QUINTERO
  • Publication number: 20240285831
    Abstract: The present disclosure describes the use of immune modulators to promote nerve growth and regeneration, particularly in the context of nerve deficit stemming from trauma and disease. In particular, the disclosure provides for the use of CXCR4 antagonists, STAT3 activators, and an agent that increases levels of nitric oxide, either alone or in any combination of these drugs, in surgery performed to treat nerve deficit conditions, especially peripheral nerve deficit conditions caused by cut injury or tear injury, the method especially useful in bridging nerve gaps of 3 cm or longer.
    Type: Application
    Filed: April 29, 2024
    Publication date: August 29, 2024
    Applicants: The Board of Regents of The University of Texas System
    Inventors: Jonathan CHENG, Edward KEEFER, Srikanth VASUDEVAN
  • Publication number: 20240269343
    Abstract: The present disclosure describes the use of immune modulators to promote nerve growth and regeneration, particularly in the context of nerve deficit stemming from trauma and disease. In particular, the disclosure provides for the use of of CXCR4 antagonsists, STAT3 activators, and an agent that increase nitric oxide, alone or in combination, to treat nerve deficit conditions.
    Type: Application
    Filed: April 10, 2024
    Publication date: August 15, 2024
    Inventors: Jonathan CHENG, Edward KEEFER, Srikanth VASUDEVAN
  • Patent number: 11969522
    Abstract: The present disclosure describes the use of immune modulators to promote nerve growth and regeneration, particularly in the context of nerve deficit stemming from trauma and disease. In particular, the disclosure provides for the use of CXCR4 antagonsists, STAT3 activators, and an agent that increase nitric oxide, alone or in combination, to treat nerve deficit conditions.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: April 30, 2024
    Assignees: The Board of Regents of the University of Texas System
    Inventors: Jonathan Cheng, Edward Keefer, Srikanth Vasudevan
  • Publication number: 20240002932
    Abstract: The present disclosure relates in some aspects to methods and compositions for light-controlled in situ surface patterning of a substrate using a Click chemistry reaction. In some embodiments, a method disclosed herein comprises a copper-catalyzed alkyne-azide (CuAAC) click chemistry reaction for photocontrollable ligation of nucleic acid molecules. A large diversity of barcodes can be created in molecules on the substrate via sequential rounds of light exposure, hybridization, and ligation.
    Type: Application
    Filed: June 28, 2023
    Publication date: January 4, 2024
    Inventors: Jonathan CHENG, David Michael Patterson
  • Publication number: 20230235384
    Abstract: The present disclosure is based in part on probes, compositions, methods, and kits for simultaneous, multiplexed spatial detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
    Type: Application
    Filed: June 17, 2021
    Publication date: July 27, 2023
    Inventors: Jonathan CHENG, Dwayne DUNAWAY, Mark GREGORY, Jaemyeong JUNG, Rustem KHAFIZOV, Dae KIM, Evan Paul PERILLO, Tushar RANE, Lidan WU
  • Publication number: 20230126825
    Abstract: Provided herein are methods for determining the mislocalization of an analyte by capturing the analyte on an array and measuring the mislocalization distance.
    Type: Application
    Filed: December 22, 2022
    Publication date: April 27, 2023
    Inventors: Monica Nagendran, Jonathan Cheng, Eswar Prasad Ramachandran Iyer
  • Publication number: 20210023264
    Abstract: The present disclosure describes the use of immune modulators to promote nerve growth and regeneration, particularly in the context of nerve deficit stemming from trauma and disease. In particular, the disclosure provides for the use of of CXCR4 antagonsists, STAT3 activators, and an agent that increase nitric oxide, alone or in combination, to treat nerve deficit conditions.
    Type: Application
    Filed: July 7, 2020
    Publication date: January 28, 2021
    Applicants: The Board of Regents of the University of Texas System
    Inventors: Jonathan CHENG, Edward KEEFER, Srikanth VASUDEVAN
  • Patent number: 8207142
    Abstract: Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vitro. Methods are provided for treating methylation-linked conditions through the application of 2-pyrimidinone derivatives, such as Zebularine. Compositions, including pharmaceutical compositions, comprising such derivatives are also provided. Also provided are kits for use in inhibiting DNA methylation, which kits include an amount of a 2-pyrimidinone derivative.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: June 26, 2012
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, University of Oregon, University of Miami School of Medicine, University of Sounthern California, University of Miami
    Inventors: Eric U. Selker, Cindy B. Matsen, Peter A. Jones, Jonathan Cheng, Sheldon B. Greer, Victor E. Marquez
  • Publication number: 20100297641
    Abstract: There is disclosed 103 novel methylation-altered DNA sequences (“marker sequences”) that have distinct methylation patterns in cancer, compared to normal tissue. In many instances, these marker sequences represent novel sequences not found in the GenBank data base, and none of these marker sequences have previously been characterized with respect to their methylation pattern in human cancers including, but not limited to those of bladder and prostate. These 103 sequences have utility as diagnostic, prognostic and therapeutic markers in the treatment of human cancer, and as reagents in kits for detecting methylated CpG-containing nucleic acids.
    Type: Application
    Filed: February 12, 2010
    Publication date: November 25, 2010
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: ISABEL D.C. MARKL, PETER A. JONES, YOSHITAKA TOMIGAHARA, GANGNING LIANG, HUALIN FU, JONATHAN CHENG
  • Patent number: 7662549
    Abstract: There is disclosed 103 novel methylation-altered DNA sequences (“marker sequences”) that have distinct methylation patterns in cancer, compared to normal tissue. In many instances, these marker sequences represent novel sequences not found in the GenBank data base, and none of these marker sequences have previously been characterized with respect to their methylation pattern in human cancers including, but not limited to those of bladder and prostate. These 103 sequences have utility as diagnostic, prognostic and therapeutic markers in the treatment of human cancer, and as reagents in kits for detecting methylated CpG-containing nucleic acids.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: February 16, 2010
    Assignee: The University of Southern California
    Inventors: Isabel D. C. Markl, Peter A. Jones, Yoshitaka Tomigahara, Gangning Liang, Hualin Fu, Jonathan Cheng
  • Publication number: 20050119201
    Abstract: Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vitro. Methods are provided for treating methylation-linked conditions through the application of 2-pyrimidinone derivatives, such as Zebularine. Compositions, including pharmaceutical compositions, comprising such derivatives are also provided. Also provided are kits for use in inhibiting DNA methylation, which kits include an amount of a 2-pyrimidinone derivative.
    Type: Application
    Filed: July 30, 2002
    Publication date: June 2, 2005
    Inventors: Eric Selker, Cindy Matsen, Peter Jones, Jonathan Cheng, Sheldon Greer, Victor Marquez
  • Patent number: 6731314
    Abstract: A client computer program provides instructions for a processor to locate and retrieve rich media and HTML files for running in a three-dimensional graphical user interface. The program provides instructions for the processor to generate a three-dimensional (3D) graphical user interface on a display. Then, the processor generates a metaphorical user object for navigating and interacting in the three dimensions within the environment via navigational and interactional inputs, respectively, from a user. The processor also integrates an HTML object into the environment, and interacts the user object with the HTML object in response to an interactional input from the user. Preferably, the processor generates one or more additional user objects for additional users. Each of the additional user objects can also interact with the HTML object, the first user object and/or each other within the environment in response to interactional inputs from the additional users.
    Type: Grant
    Filed: August 16, 1999
    Date of Patent: May 4, 2004
    Assignee: Muse Corporation
    Inventors: Gavin Cheng, Jonathan Cheng, Geoffrey F. Graber, Dwayne Serjeant, Payton R. White, Ivan S. Fuller, Mark C. Barnes, Ralph P. Seguin
  • Publication number: 20040028045
    Abstract: The invention discloses a data transmission method for the portable communication apparatus, comprising plurality of data transmission steps and each data transmission step is used for implementation a graphic, image, video, or audio process, wherein each step can be at least used for transmitting the 1st header for setting a graphic, image, video, or audio command, the 2nd header for designating the graphic, image, video, or audio parameter information following the graphic, image, video, or audio command and the combination of the said graphic, image, video, or audio command information, and transmitting the graphic, image, video, or audio parameter of the graphic, image, video, or audio command. In particular, if the graphic, image, video, or audio command in this data transmission step is already transmitted in the preceding data transmission step, then, the step for transmitting the 1st header can be omitted.
    Type: Application
    Filed: August 9, 2002
    Publication date: February 12, 2004
    Inventor: Jonathan Cheng
  • Patent number: 5533541
    Abstract: An automatic umbrella including an inside cap at the top of the umbrella shaft thereof, a top runner mounted around the umbrella shaft, an open control spring mounted between the inside cap and the top runner and compressed to preserve energy for opening the umbrella when the umbrella is collapsed, a collapse control spring compressed and retained in the compressed position by means of the operation of the hook of a locating device on the top end of the bottom shaft of the umbrella shaft, and the operation of the detent of a release control device inside the umbrella shaft, to preserve energy for collapsing the umbrella when the umbrella is opened, and a control block with a push plate moved vertically to actuate the release control device in automatically opening/closing the umbrella, and a bottom runner having a hook hooked on the umbrella shaft for allowing the umbrella to be operated manually when the hook of the bottom runner is released.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: July 9, 1996
    Inventors: Jonathan Cheng, Luk Chou
  • Patent number: 5463536
    Abstract: An umbrella having a light source mounted inside the umbrella handle and controlled by a slide switch to give off light through a refractor around the umbrella shaft, wherein the umbrella shaft is a transparent, solid, polygonal rod having a refracting area for refracting the light of the light source toward the ribs and umbrella cover of the umbrella.
    Type: Grant
    Filed: February 28, 1995
    Date of Patent: October 31, 1995
    Inventors: Luk Chou, Jonathan Cheng, Chin I. Lin
  • Patent number: 5309932
    Abstract: A folding collapsible frame assembly for an automatic folding umbrella, which includes a lower shaft, an upper shaft made to slide in the upper shaft, a collapse control spring, a lock ring moved to lock the collapse control spring in the compressed condition as the umbrella is opened, a stretch control spring controlled by a bottom spring on the handle of the umbrella to automatically push the umbrella into the open condition, a guide control mechanism controlled by a control bottom on the handle of the umbrella to release the lock ring from the collapse control spring for allowing the umbrella to be collapsed automatically.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: May 10, 1994
    Inventors: Lue L. C. Chou, Jonathan Cheng
  • Patent number: D875290
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: February 11, 2020
    Assignee: METROMAX AMERICA CORPORATION
    Inventor: Jonathan Cheng Yu Hwang