Abstract: Example implementations include a method, apparatus and computer-readable medium in a video surveillance system for tracking an of-interest (OI) object, comprising receiving, from a user interface, a request to track an object in a first video stream from a plurality of video streams captured from a first camera of a plurality of cameras installed in an environment. The implementations further include extracting at least one image of the object from the first video stream. Additionally, the implementations further include generating a unique biometric identifier of the object based on the at least one image. Additionally, the implementations further include detecting, using the unique biometric identifier, the object in a second video stream captured from a second camera of the plurality of cameras, and outputting, on the user interface, the second video stream in response to detecting the object in the second video stream.

Abstract: The present invention provides NRP1 as a cell surface marker for isolating human cardiomyogenic ventricular progenitor cells (HVPs), in particular progenitor cells that preferentially differentiate into cardiac ventricular muscle cells. Additional HVP cell surface markers identified by single cell sequencing are also provided. The invention provides in vitro methods of the separation of NRP1+ ventricular progenitor cells, and the large scale expansion and propagation thereof. Large clonal populations of isolated NRP1+ ventricular progenitor cells are also provided. Methods of in vivo use of NRP1+ ventricular progenitor cells for cardiac repair or to improve cardiac function are also provided. Methods of using the NRP1+ ventricular progenitor cells for cardiac toxicity screening of test compounds are also provided.

Abstract: Example implementations include a method, apparatus and computer-readable medium in a video surveillance system for tracking an of-interest (OI) object, comprising receiving, from a user interface, a request to track an object in a first video stream from a plurality of video streams captured from a first camera of a plurality of cameras installed in an environment. The implementations further include extracting at least one image of the object from the first video stream. Additionally, the implementations further include generating a unique biometric identifier of the object based on the at least one image. Additionally, the implementations further include detecting, using the unique biometric identifier, the object in a second video stream captured from a second camera of the plurality of cameras, and outputting, on the user interface, the second video stream in response to detecting the object in the second video stream.

Abstract: The disclosure relates to modified RNA molecules encoding VEGF-A polypeptides and formulations comprising the modified RNA. Aspects of the disclosure further relate to preparations and uses of formulations comprising the modified RNA in treating subjects suffering from diseases responsive to VEGF-A therapy.

Abstract: The present invention provides genetic markers for identifying engraftable human cardiac ventricular progenitor cells. The engraftment markers of the invention include angiogenic markers and extracellular matrix markers. Human ventricular progenitor cells expressing these markers are capable of forming ventricular tissue in vivo that is vascularized and supported by an extracellular matrix. Methods of engrafting human cardiac ventricular progenitor cells by transplanting into a subject progenitor cells that express the engraftment markers are also provided.

Abstract: The present invention provides genetic markers for identifying engraftable human cardiac ventricular progenitor cells. The engraftment markers of the invention include angiogenic markers and extracellular matrix markers. Human ventricular progenitor cells expressing these markers are capable of forming ventricular tissue in vivo that is vascularized and supported by an extracellular matrix. Methods of engrafting human cardiac ventricular progenitor cells by transplanting into a subject progenitor cells that express the engraftment markers are also provided.

Abstract: This disclosure is for an endoluminal delivery cannula, for delivery of a substance to an extravascular target site via the vascular system of a human or animal body, wherein the cannula comprises a proximal cannula hub, an elongated proximal, and a tip portion. The tip is tapered towards the distal tip which is preferably provided with a pointed tip for penetrating tissue. The pointed tip may comprise at least one primary facet and two secondary facets, wherein the two secondary facets are arranged proximally of said primary facet. An endoluminal delivery assembly comprises the cannula, a protective catheter adapted for insertion into the vascular system of a human or animal body, and a proximal catheter hub provided at the proximal end of the catheter and adapted for guiding the catheter through the vascular system.

Abstract: The present invention provides methods for isolating human cardiac ventricular progenitor cells (HVPs), wherein cultures of day 5-7 cardiac progenitor cells are negatively selected for one or more first markers expressed on human pluripotent stem cells, such as TRA-1-60, to thereby isolate HVPs. The methods can further include positive selection for expression of a second marker selected from the group consisting of JAG1, FZD4, LIFR, FGFR3 and TNFSF9. Large populations, including clonal populations, of isolated HVPs that are first marker negative/second marker positive are also provided. Methods of in vivo use of the HVPs for cardiac repair or to improve cardiac function are also provided. Methods of using the HVPs for cardiac toxicity screening of test compounds are also provided.

Abstract: The present invention provides NRP1 as a cell surface marker for isolating human cardiomyogenic ventricular progenitor cells (HVPs), in particular progenitor cells that preferentially differentiate into cardiac ventricular muscle cells. Additional HVP cell surface markers identified by single cell sequencing are also provided. The invention provides in vitro methods of the separation of NRP1+ ventricular progenitor cells, and the large scale expansion and propagation thereof. Large clonal populations of isolated NRP1+ ventricular progenitor cells are also provided. Methods of in vivo use of NRP1+ ventricular progenitor cells for cardiac repair or to improve cardiac function are also provided. Methods of using the NRP1+ ventricular progenitor cells for cardiac toxicity screening of test compounds are also provided.

Abstract: The present invention provides NRP1 as a cell surface marker for isolating human cardiomyogenic ventricular progenitor cells (HVPs), in particular progenitor cells that preferentially differentiate into cardiac ventricular muscle cells. Additional HVP cell surface markers identified by single cell sequencing are also provided. The invention provides in vitro methods of the separation of NRP1+ ventricular progenitor cells, and the large scale expansion and propagation thereof. Large clonal populations of isolated NRP1+ ventricular progenitor cells are also provided. Methods of in vivo use of NRP1+ ventricular progenitor cells for cardiac repair or to improve cardiac function are also provided. Methods of using the NRP1+ ventricular progenitor cells for cardiac toxicity screening of test compounds are also provided.

Abstract: The disclosure relates to modified RNA molecules encoding VEGF-A polypeptides and formulations comprising the modified RNA. Aspects of the disclosure further relate to preparations and uses of formulations comprising the modified RNA in treating subjects suffering from diseases responsive to VEGF-A therapy.

Abstract: The present invention provides genetic markers for identifying engraftable human cardiac ventricular progenitor cells. The engraftment markers of the invention include angiogenic markers and extracellular matrix markers. Human ventricular progenitor cells expressing these markers are capable of forming ventricular tissue in vivo that is vascularized and supported by an extracellular matrix. Methods of engrafting human cardiac ventricular progenitor cells by transplanting into a subject progenitor cells that express the engraftment markers are also provided.

Abstract: The present invention provides methods for isolating human cardiac ventricular progenitor cells (HVPs), wherein cultures of day 5-7 cardiac progenitor cells are negatively selected for one or more first markers expressed on human pluripotent stem cells, such as TRA-1-60, to thereby isolate HVPs. The methods can further include positive selection for expression of a second marker selected from the group consisting of JAG1, FZD4, LIFR, FGFR3 and TNFSF9. Large populations, including clonal populations, of isolated HVPs that are first marker negative/second marker positive are also provided. Methods of in vivo use of the HVPs for cardiac repair or to improve cardiac function are also provided. Methods of using the HVPs for cardiac toxicity screening of test compounds are also provided.

Abstract: A vehicle includes a first member inflatable to an inflated position in which the first member has a first and a second distal edge spaced from each other along a vehicle-longitudinal axis. The vehicle includes a second member inflatable to an inflated position, the second member in the inflated position being on a cross-vehicle axis that extends through the first distal edge. The vehicle includes a one-way vent permitting fluid flow from the first member to the second member.

Abstract: Several systems for tracking one or more radiation blocking objects on a surface are disclosed. A pair of radiation sensors are provided adjacent the surface and a plurality of radiation sources are provided adjacent the surface. Radiation from at least some of the radiation sources travels across the surface to reach each of the radiation sensors. One or more radiation blocking objects on the surface attenuate radiation from one or more radiation sources from reaching each of the sensors. The position of the one or more radiation blocking objects is estimates and may be tracked based on the position of the one or more attenuated radiation sources relative to each radiation sensor.

Abstract: The present invention provides genetic markers for identifying engraftable human cardiac ventricular progenitor cells. The engraftment markers of the invention include angiogenic markers and extracellular matrix markers. Human ventricular progenitor cells expressing these markers are capable of forming ventricular tissue in vivo that is vascularized and supported by an extracellular matrix. Methods of engrafting human cardiac ventricular progenitor cells by transplanting into a subject progenitor cells that express the engraftment markers are also provided.

Abstract: The present invention provides methods for isolating human cardiac ventricular progenitor cells (HVPs), wherein cultures of day 5-7 cardiac progenitor cells are negatively selected for one or more first markers expressed on human pluripotent stem cells, such as TRA-1-60, to thereby isolate HVPs. The methods can further include positive selection for expression of a second marker selected from the group consisting of JAG1, FZD4, LIFR, FGFR3 and TNFSF9. Large populations, including clonal populations, of isolated HVPs that are first marker negative/second marker positive are also provided. Methods of in vivo use of the HVPs for cardiac repair or to improve cardiac function are also provided. Methods of using the HVPs for cardiac toxicity screening of test compounds are also provided.

Abstract: A vehicle includes a first member inflatable to an inflated position in which the first member has a first and a second distal edge spaced from each other along a vehicle-longitudinal axis. The vehicle includes a second member inflatable to an inflated position, the second member in the inflated position being on a cross-vehicle axis that extends through the first distal edge. The vehicle includes a one-way vent permitting fluid flow from the first member to the second member.

Abstract: A spare wheel assembly winch having a force dependent cable release mechanism is disclosed. In one embodiment, the sheave includes a series of breakaway features that can be torn if the tension on the spare tire cable exceeds the predetermined level, thus allowing the inner, gear-containing portion of the sheave to rotate independently of the outer, cable-holding portion. In another embodiment, the sheave includes a series of breakaway notches formed on the gear teeth of the internal gear. In a further embodiment, a frangible tab extends from torque plate into a depression formed in the cover plate. In yet another embodiment, a tear feature extends from the housing and is situated adjacent the torque plate arm. In an additional embodiment, frangible tabs extend from the body of the sheave into a geared insert. In still another embodiment, a frangible tab extends from a geared insert into the torque plate.

Abstract: Two dimensional position sensing system and sensors for use in such systems are disclosed. The sensors incorporate linear array sensors having sensor elements and an aperture plate. Some embodiments include a radiation source that directs radiation onto some of the sensor elements. Other embodiments including radiation blocking objects that block radiation from reaching some of sensor elements. The direction or position of the radiation source or radiation blocking object may be estimated from the radiation incident on the sensor elements.