Patents by Inventor Jonathan Clive Stephens

Jonathan Clive Stephens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Attenuated bacteria useful in vaccines
    Patent number: 8318148
    Abstract: The invention provides strains of bacteria, especially enterotoxigenic E. coli, attenuated by mutations in the genes encoding enterotoxins (LT, ST, EAST1) and optionally further attenuated by deletion of additional chromosomal genes. In addition the invention provides strains of attenuated bacteria expressing immunogenic but non-toxic variants of one or more of these enterotoxins. These bacteria are useful as a vaccine against diarrhoeal disease.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: November 27, 2012
    Assignee: Acambis Research Limited
    Inventors: Arthur Keith Turner, Judith Greenwood, Jonathan Clive Stephens, Juliet Claire Beavis, Michael James Darsley
  • BACTERIAL VACCINE
    Publication number: 20110200638
    Abstract: A bacterial cell which expresses three or more coli surface (CS) antigens and methods of making such a cell. The cell is useful in making vaccines against diarrhea.
    Type: Application
    Filed: April 7, 2011
    Publication date: August 18, 2011
    Applicant: ACAMBIS RESEARCH LIMITED
    Inventors: Arthur Keith Turner, Judith Greenwood, Jonathan Clive Stephens, Juliet Claire Beavis, Michael James Darsley
  • Bacterial vaccine
    Patent number: 7951361
    Abstract: A bacterial cell which expresses three or more coli surface (CS) antigens and methods of making such a cell. The cell is useful in making vaccines against diarrhea.
    Type: Grant
    Filed: September 11, 2002
    Date of Patent: May 31, 2011
    Assignee: Acambis Research Limited
    Inventors: Arthur Keith Turner, Judith Greenwood, Jonathan Clive Stephens, Juliet Claire Beavis, Michael James Darsley
  • Attenuated bacteria useful in vaccines
    Patent number: 7943122
    Abstract: The invention provides strains of bacteria, especially enterotoxigenic E. coli, attenuated by mutations in the genes encoding enterotoxins (LT, ST, EAST1) and optionally further attenuated by deletion of additional chromosomal genes. In addition the invention provides strains of attenuated bacteria expressing immunogenic but non-toxic variants of one or more of these enterotoxins. These bacteria are useful as a vaccine against diarrhoeal disease.
    Type: Grant
    Filed: September 11, 2002
    Date of Patent: May 17, 2011
    Assignee: Acambis Research Limited
    Inventors: Arthur Keith Turner, Judith Greenwood, Jonathan Clive Stephens, Juliet Claire Beavis, Michael James Darsley
  • Bacterial vaccine
    Publication number: 20040253710
    Abstract: A bacterial cell which expresses three or more coli surface (CS) antigens and methods of making such a cell. The cell is useful in making vaccines against diarrhoea.
    Type: Application
    Filed: August 5, 2004
    Publication date: December 16, 2004
    Inventors: Arthur Keith Turner, Judith Greenwood, Jonathan Clive Stephens, Juliet Claire Beavis, Michael James Darsley
  • Stabilisation of plasmid inheritance in bacteria
    Publication number: 20030170264
    Abstract: The invention relates to a vaccine comprising a pharmaceutically acceptable carrier or diluent and a bacterium, wherein the bacterium contains (i) a DNA sequence encoding a site-specific recombinase, and (ii) a plasmid comprising a recognition element for the recombinase and a DNA sequence encoding a heterologous polypeptide. The recombinase stabilises inheritance of the plasmid and thereby prevents the bacterium from losing the ability to express the heterologous polypeptide.
    Type: Application
    Filed: April 3, 2003
    Publication date: September 11, 2003
    Inventors: Arthur Keith Turner, Jonathan Clive Stephens