Abstract: The present invention relates to compounds of formula (I) wherein Q is selected from O or S; R1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R1 is attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein R1 may optionally be substituted; and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-?-lactamase inhibitors.

Abstract: The present invention relates to sulfonylureas and sulfonylthioureas comprising a 5-membered heteroaryl ring attached to the sulfonyl group, wherein the heteroaryl ring is di-substituted at the 3- and 4-positions relative to the point of attachment of the sulfonyl group, wherein at least one of the di-substituents contains a nitrogen atom. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: A breather is disclosed. The breather may have a breather housing, a desiccant material, and a moisture indicator. The breather housing may be configured to receive at least an air flow containing moisture. The desiccant material may be contained within the breather housing, and the desiccant material may be enclosed by a breather wall. The moisture indicator may be located within the breather housing, and the moisture indicator may be positioned between the desiccant material and an internal side of the breather wall. The moisture indicator may provide a visible representation of an amount of moisture adsorbed by the desiccant breather. The visible representation of the moisture indicator may be visually observable through the breather wall. The desiccant material may be configured to adsorb up to about forty percent (40%) of the desiccant material's weight in moisture.

Abstract: The present invention relates to macrocyclic compounds, such as macrocyclic sulfonyl amides. The present invention further relates to associated salts, solvates, prodrugs and pharmaceutical compositions, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.

Abstract: A computer system is provided that includes a paired list of data transaction requests on which a matching process is performed. There are multiple different types of data transaction requests that are stored in the paired list including data transaction requests with midpoint attributes and data transaction requests with discretion attributes. The computer system may determine how the multiple different types of data transaction requests may be match against each other. Two matching processes can be used to determine if a match exists between the first and second sides of the paired list. Matches that are determined at private values are not disseminated to third-parties via public market data feeds.

Abstract: A component life prediction system configured to predict the remaining life of a consumable component installed on an aircraft. The system includes a processor configured to: receive wear information indicative of a current wear state of the component; receive schedule information indicative of a future flight schedule for the aircraft; and determine the remaining life of the component based on the received wear information and the received schedule information.

Abstract: The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R1 is attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein R1 may optionally be substituted; and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections. More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-?-lactamase inhibitors.

Abstract: A device is disclosed for the preparation of nebulised droplets, for inhalation. The device has: a surface acoustic wave (SAW) transmission surface; a SAW transducer adapted to generate and propagate SAWs along the SAW transmission surface; and an array of cavities opening at the SAW transmission surface for containing a liquid. In operation, SAWs propagating along the SAW transmission surface interact with the liquid in the cavities to produce nebulised droplets of the liquid. Operation of the device results in a nebulised plume of droplets of average diameter in the range 1-5 ?m.

Abstract: The present invention relates to macrocyclic compounds, such as macrocyclic sulfonyl ureas. The present invention further relates to associated salts, solvates, prodrugs and pharmaceutical compositions and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.

Abstract: The present invention relates to a NOx storage material comprising a cerium-based mixed oxide comprising cerium, oxygen, and a first rare earth metal other than cerium, wherein said NOx storage material further comprises a second rare earth metal other than cerium; wherein said first rare earth metal is different to said second rare earth metal; and wherein said second rare earth metal is disposed or supported on the surface of the cerium-based mixed oxide.

Abstract: The present invention relates to compounds of formula (I): wherein Q is O or S, R1 is a 6-membered heteroaryl group containing at least one nitrogen atom in the 6-membered ring structure, wherein R1 may optionally be substituted, and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: An audio system and method for modifying an audio playback including configuring an audio playback device, the audio playback device comprising a plurality of far-field audio inputs; generating the audio playback via the audio playback device; receiving, via at least one far-field audio input of the plurality of far-field audio inputs, a content-agnostic audio input from a first position within an environment; and, modifying the audio playback in response to the content-agnostic audio input.

Abstract: A device is disclosed for the preparation of nebulised droplets, for inhalation. The device has: a surface acoustic wave (SAW) transmission surface; a SAW transducer adapted to generate and propagate SAWs along the SAW transmission surface; and an array of cavities opening at the SAW transmission surface for containing a liquid. In operation, SAWs propagating along the SAW transmission surface interact with the liquid in the cavities to produce nebulised droplets of the liquid. Operation of the device results in a nebulised plume of droplets of average diameter in the range 1-5 ?m.

Abstract: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

Abstract: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

Abstract: An aircraft is disclosed having a wing, the wing having a fixed wing with a wing tip device moveably mounted about a hinge at the tip thereof. The wing tip device is operable between a flight configuration, and a load alleviating configuration for load alleviation during flight. The aircraft includes a restraining assembly operable between a restraining mode in which the wing tip device is held in the flight configuration using a restraining force such as by a brake, and a releasing mode in which the restraining force on the wing tip device is released, such that the wing tip device may adopt the load alleviating configuration.

Abstract: An aircraft is disclosed having a wing, the wing having a fixed wing with a wing tip device moveably mounted about a hinge at the tip thereof. The wing tip device is operable between a flight configuration, and a load alleviating configuration for load alleviation during flight. The aircraft includes a restraining assembly operable between a restraining mode in which the wing tip device is held in the flight configuration using a restraining force such as by a brake, and a releasing mode in which the restraining force on the wing tip device is released, such that the wing tip device may adopt the load alleviating configuration.

Abstract: An audio system and method for modifying an audio playback including configuring an audio playback device, the audio playback device comprising a plurality of far-field audio inputs; generating the audio playback via the audio playback device; receiving, via at least one far-field audio input of the plurality of far-field audio inputs, a content-agnostic audio input from a first position within an environment; and, modifying the audio playback in response to the content-agnostic audio input.