Abstract: Apparatuses, systems, and methods are disclosed for providing controlled delivery of energy treatment to a tissue site. The systems, apparatuses, and methods may include designs with features for efficiently deploying and adjusting electrodes at a tissue site for treatment and for facilitating retraction of the electrodes back into a housing after completion of treatment for removal. The systems, apparatuses, and methods may further include an expansion member for radially expanding the flexible substrate to aid in positioning the electrodes adjacent the tissue to facilitate treatment.

Abstract: Apparatuses, systems, and methods are disclosed for providing controlled delivery of energy treatment to a tissue site. The systems, apparatuses, and methods may include medical instrument designs with features for retaining a flexible substrate with an electrode array in position against an expandable member during delivery to the tissue site, treatment, and retraction from the tissue site. The medical instrument further includes features for retaining the flexible substrate in a compact, stowed configuration during delivery and for retracting the flexible substrate post-deployment to facilitate retraction of the medical instrument after completion of treatment.

Abstract: An electrode treatment device includes an electrode strip arranged in the shape of a helix with a first end of the electrode strip attached to an elongate flexible body, such as a catheter tube, and a second end of the electrode strip attached to a flexible shaft that extends from the body. When the helical electrode is contracted around the body and/or shaft, the device may be less than 2 mm in diameter to facilitate endoluminal insertion and treatment of gastrointestinal or lung tissue, for example. The shaft is rotatable relative to the body to radially expand the helix to a deployed position in apposition to target tissue for electrosurgical treatment (e.g., treatment in a lumen). The electrode strip may consist of conductive foil or may comprise a flexible printed circuit with one or more electrodes formed thereon. The device may be operated by a robotic manipulator.

Abstract: A delivery system for delivering a heart valve prosthesis includes a delivery catheter and a heart valve prosthesis. The delivery catheter includes an outer sheath, an inner shaft, a distal nosecone, and a deflecting segment. The inner shaft is slidably disposed within the outer sheath. A distal end of the inner shaft is coupled to a proximal end of the deflecting segment, and a distal end of the deflecting segment is coupled to the distal nosecone. The deflecting segment includes a delivery state with the deflecting segment and the distal nosecone having a combined first longitudinal length. The deflecting segment further includes a deflected state with the deflecting segment having a second longitudinal length that is less than the first longitudinal length. The heart valve prosthesis includes a radially collapsed configuration and a radially expanded configuration. The deflecting segment is shape-set to the deflected state.

Abstract: A delivery system for delivering a heart valve prosthesis includes a delivery catheter and a heart valve prosthesis. The delivery catheter includes an outer sheath, an inner shaft, a distal nosecone, and a deflecting segment. The inner shaft is slidably disposed within the outer sheath. A distal end of the inner shaft is coupled to a proximal end of the deflecting segment, and a distal end of the deflecting segment is coupled to the distal nosecone. The deflecting segment includes a delivery state with the deflecting segment and the distal nosecone having a combined first longitudinal length. The deflecting segment further includes a deflected state with the deflecting segment having a second longitudinal length that is less than the first longitudinal length. The heart valve prosthesis includes a radially collapsed configuration and a radially expanded configuration. The deflecting segment is shape-set to the deflected state.

Abstract: Methods and apparatus are disclosed for customizing an elution rate of a stent. The stent includes a hollow strut that forms the stent, the hollow strut defining a lumenal space, a drug formulation disposed within the lumenal space of the hollow strut, and at least one side port for eluting the drug formulation in vivo. When the stent is in the radially expanded configuration the hollow strut is deformable from a first configuration that has a first elution rate for the drug formulation to a second configuration that has a second elution rate for the drug formulation. The second elution rate is faster than the first elution rate. The hollow strut deforms from the first configuration to the second configuration upon application of an applied pressure above a predetermined threshold.

Abstract: Methods and apparatus are disclosed for customizing an elution profile of a stent after manufacture of the stent has been completed. The stent includes a plurality of side ports for eluting a drug formulation within a lumenal space of a hollow strut that forms the stent. An effective diameter of at least one side port of the plurality of side ports of the stent is modified in order to customize an elution profile of the stent. In an embodiment hereof, the plurality of side ports are completely blocked or plugged with a filler material during the manufacture of the stent and at least a portion of the filler material is removed to increase an effective diameter of at least one side port of the plurality of side ports of the stent in order to customize an elution profile of the stent.

Abstract: A delivery system for delivering a heart valve prosthesis includes a delivery catheter and a heart valve prosthesis. The delivery catheter includes an outer sheath, an inner shaft, a distal nosecone, and a deflecting segment. The inner shaft is slidably disposed within the outer sheath. A distal end of the inner shaft is coupled to a proximal end of the deflecting segment, and a distal end of the deflecting segment is coupled to the distal nosecone. The deflecting segment includes a delivery state with the deflecting segment and the distal nosecone having a combined first longitudinal length. The deflecting segment further includes a deflected state with the deflecting segment having a second longitudinal length that is less than the first longitudinal length. The heart valve prosthesis includes a radially collapsed configuration and a radially expanded configuration. The deflecting segment is shape-set to the deflected state.

Abstract: Methods and apparatus are disclosed for customizing an elution rate of a stent. The stent includes a hollow strut that forms the stent, the hollow strut defining a lumenal space, a drug formulation disposed within the lumenal space of the hollow strut, and at least one side port for eluting the drug formulation in vivo. When the stent is in the radially expanded configuration the hollow strut is deformable from a first configuration that has a first elution rate for the drug formulation to a second configuration that has a second elution rate for the drug formulation. The second elution rate is faster than the first elution rate. The hollow strut deforms from the first configuration to the second configuration upon application of an applied pressure above a predetermined threshold.

Abstract: Methods and apparatus are disclosed for customizing an elution profile of a stent after manufacture of the stent has been completed. The stent includes a plurality of side ports for eluting a drug formulation within a lumenal space of a hollow strut that forms the stent. An effective diameter of at least one side port of the plurality of side ports of the stent is modified in order to customize an elution profile of the stent. In an embodiment hereof, the plurality of side ports are completely blocked or plugged with a filler material during the manufacture of the stent and at least a portion of the filler material is removed to increase an effective diameter of at least one side port of the plurality of side ports of the stent in order to customize an elution profile of the stent.

Abstract: A balloon catheter includes an elongated catheter shaft, a hub disposed at a proximal portion of the catheter shaft, an inflatable balloon disposed at a distal portion of the catheter shaft, and a refold tool slidingly disposed over the elongated catheter shaft and positioned between the hub and the inflatable balloon. The balloon is configured to transform between an inflated configuration and a deflated configuration, the balloon having a deflated profile when in the deflated configuration. The refold tool defines a lumen there-through that is flared at a distal end thereof, and the lumen of the tubular component of the refold tool is sized to refold the balloon to a refolded profile that is smaller than the deflated profile when the balloon in the deflated configuration passes through the refold tool.