Abstract: The present invention relates to a process for preparing hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]-3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester of formula (I). In accordance with the present invention, the compound (I) can be efficiently prepared with high purity by coupling bimatoprost in a boronate protected form with 6-(nitrooxy)hexanoyl chloride and removing the boronate protecting group. The invention also relates to a process for the preparation of 6-(nitrooxy) hexanoic acid having a HPLC purity equal to or greater than 99% and containing an amount of 6-{[6-(nitrooxy)hexanoyl]oxy}hexanoic acid (compound (IXa) equal to or lower than 0.2%.

Abstract: Disclosed embodiments relate to the graphical display of relationships between entities of interest, and specifically between entities in a network of relationships. In such embodiments, multiple icons on an axis between two entities are used to indicate that the entities have multiple relationships. Disclosed embodiments also provide methods of navigating, filtering, and manipulating the display of networked relationships, according to the numerical distribution of relationships and specific combinations of relationships. Disclosed embodiments provide methods of manipulating the display of networked relationships so that relationships between entities can be visually collapsed, and entities can be treated as links between other entities for the purposes of filtering and display.