Abstract: The present disclosure relates to an apparatus and methods for treating mastitis in lactating mothers by addressing clogged milk ducts. In some embodiments, the system includes an angled pump flange designed to work with a breast pump to facilitate the removal of ductal plugs that lead to mastitis. In some embodiments, the flange is structured to maintain substantial contact with the breast, allowing for manipulation such as pulling, pushing, and rotation, to dislodge plugs while a vacuum is applied. In some embodiments, the interior surface of the flange provides increased friction against the skin to resist relative motion during manipulation. In some embodiments, the flange's semi-rigid or rigid construction maintains its shape during use, enabling effective manipulation of the breast without losing connection. In some embodiments, the system may also include a breast pump with adjustable suction cycles to simulate a nursing baby and encourage milk flow.

Abstract: Methods for nanopore-based protein analysis are provided. The methods address the characterization of a target protein analyte, which has a dimension greater than an internal diameter of the nanopore tunnel, and which is also physically associated with a polymer. The methods further comprise applying an electrical potential to the nanopore system to cause the polymer to interact with the nanopore tunnel. The ion current through the nanopore is measured to provide a current pattern reflective of the structure of the portion of the polymer interacting with the nanopore tunnel. This is used as a metric for characterizing the associated protein that does not pass through the nanopore.

Abstract: Methods for nanopore-based protein analysis are provided. The methods address the characterization of a target protein analyte, which has a dimension greater than an internal diameter of the nanopore tunnel, and which is also physically associated with a polymer. The methods further comprise applying an electrical potential to the nanopore system to cause the polymer to interact with the nanopore tunnel. The ion current through the nanopore is measured to provide a current pattern reflective of the structure of the portion of the polymer interacting with the nanopore tunnel. This is used as a metric for characterizing the associated protein that does not pass through the nanopore.

Abstract: Methods for nanopore-based protein analysis are provided. The methods address the characterization of a target protein analyte, which has a dimension greater than an internal diameter of the nanopore tunnel, and which is also physically associated with a polymer. The methods further comprise applying an electrical potential to the nanopore system to cause the polymer to interact with the nanopore tunnel. The ion current through the nanopore is measured to provide a current pattern reflective of the structure of the portion of the polymer interacting with the nanopore tunnel. This is used as a metric for characterizing the associated protein that does not pass through the nanopore.

Abstract: A method (60) of determining core orientation of a core sample (12) cut from the ground by a drill rig (10) having a drill string and a drill bit (20) coupled to a downhole end of the drill string. Drilling data (Cn, Rn) is continuously acquired while the drill rig (10) is operating to cut and retrieve the core sample (12). The drilling data is a combination of core orientation data Cn and rig operational data Rn, where the rig operational data is constituted by either one or both of: (a) near bit rig data Nn; and, (b) at surface rig data Sn. The drilling data is analyzed for a specific pattern of rig operational data Rn indicative of the core sample being broken from ground by operation of the drill rig (10). On detection of the specific pattern, the orientation of the core sample prior to being broken from the ground is the acquired core orientation data Cn coinciding with that specific pattern of rig operational data Rn.

Abstract: The present invention relates to photoactivatable compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA.

Abstract: Methods for nanopore-based protein analysis are provided. The methods address the characterization of a target protein analyte, which has a dimension greater than an internal diameter of the nanopore tunnel, and which is also physically associated with a polymer. The methods further comprise applying an electrical potential to the nanopore system to cause the polymer to interact with the nanopore tunnel. The ion current through the nanopore is measured to provide a current pattern reflective of the structure of the portion of the polymer interacting with the nanopore tunnel. This is used as a metric for characterizing the associated protein that does not pass through the nanopore.

Abstract: The present invention relates to photoactivatable compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA.

Abstract: Methods for nanopore-based protein analysis are provided. The methods address the characterization of a target protein analyte, which has a dimension greater than an internal diameter of the nanopore tunnel, and which is also physically associated with a polymer. The methods further comprise applying an electrical potential to the nanopore system to cause the polymer to interact with the nanopore tunnel. The ion current through the nanopore is measured to provide a current pattern reflective of the structure of the portion of the polymer interacting with the nanopore tunnel. This is used as a metric for characterizing the associated protein that does not pass through the nanopore.

Abstract: A method (60) of determining core orientation of a core sample (12) cut from the ground by a drill rig (10) having a drill string and a drill bit (20) coupled to a downhole end of the drill string. Drilling data (Cn, Rn) is continuously acquired while the drill rig (10) is operating to cut and retrieve the core sample (12). The drilling data is a combination of core orientation data Cn and rig operational data Rn, where the rig operational data is constituted by either one or both of: (a) near bit rig data Nn; and, (b) at surface rig data Sn. The drilling data is analysed for a specific pattern of rig operational data Rn indicative of the core sample being broken from ground by operation of the drill rig (10). On detection of the specific pattern, the orientation of the core sample prior to being broken from the ground is the acquired core orientation data Cn coinciding with that specific pattern of rig operational data Rn.

Abstract: Methods for nanopore-based protein analysis are provided. The methods address the characterization of a target protein analyte, which has a dimension greater than an internal diameter of the nanopore tunnel, and which is also physically associated with a polymer. The methods further comprise applying an electrical potential to the nanopore system to cause the polymer to interact with the nanopore tunnel. The ion current through the nanopore is measured to provide a current pattern reflective of the structure of the portion of the polymer interacting with the nanopore tunnel. This is used as a metric for characterizing the associated protein that does not pass through the nanopore.

Abstract: An electrified axle system includes a pair of wheels, a super positioning torque vectoring differential coupled between the wheels, and a controller. The super positioning torque vectoring differential includes a traction motor and a vectoring motor. The controller operates the vectoring motor in speed control mode to reduce a speed difference between the wheels responsive to the difference exceeding a threshold, and operates the vectoring motor in torque control mode responsive to the difference falling within a target range and an accelerator pedal position achieving a value that depends on lateral acceleration associated with the system.

Abstract: Methods for nanopore-based protein analysis are provided. The methods address the characterization of a target protein analyte, which has a dimension greater than an internal diameter of the nanopore tunnel, and which is also physically associated with a polymer. The methods further comprise applying an electrical potential to the nanopore system to cause the polymer to interact with the nanopore tunnel. The ion current through the nanopore is measured to provide a current pattern reflective of the structure of the portion of the polymer interacting with the nanopore tunnel. This is used as a metric for characterizing the associated protein that does not pass through the nanopore.

Abstract: An electrified axle system includes a pair of wheels, a super positioning torque vectoring differential coupled between the wheels, and a controller. The super positioning torque vectoring differential includes a traction motor and a vectoring motor. The controller operates the vectoring motor in speed control mode to reduce a speed difference between the wheels responsive to the difference exceeding a threshold, and operates the vectoring motor in torque control mode responsive to the difference falling within a target range and an accelerator pedal position achieving a value that depends on lateral acceleration associated with the system.

Abstract: The present invention relates to photoactivatable compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA.

Abstract: Methods for nanopore-based protein analysis are provided. The methods address the characterization of a target protein analyte, which has a dimension greater than an internal diameter of the nanopore tunnel, and which is also physically associated with a polymer. The methods further comprise applying an electrical potential to the nanopore system to cause the polymer to interact with the nanopore tunnel. The ion current through the nanopore is measured to provide a current pattern reflective of the structure of the portion of the polymer interacting with the nanopore tunnel. This is used as a metric for characterizing the associated protein that does not pass through the nanopore.

Abstract: A protective window system for non-military heavy equipment including: at least two window panes with at least one air gap therebetween wherein the thickness of each window pane and the size of the air gap is determined such that the window system meets or exceeds UL/ANSI 752 level 1 testing. In particular, the panes may be of polycarbonate, formed with a curved shape and between 5 and 30 mm thick. The air gap may be between at least two of the at least two window panes that is between 5 and 50 mm thick. The window system may include a channel for transporting conditioned air and a vent for allowing the conditioned air to enter the air gap; and a hinge mechanism for allowing at least one of the at least two window panes to move in relation to another of the at least two window panes.

Abstract: A hydraulic assembly including a pivot connection defining a pivot axis, a hydraulic element linked to the pivot connection, and a connector for connecting a hydraulic conduit to the hydraulic element. The connector defines a connection axis and the connector is configured such that the connection axis approximately intersects the pivot axis. The hydraulic assembly may be used in various applications, including in forestry equipment, for example, with a rotator link assembly.

Abstract: Methods for nanopore-based protein analysis are provided. The methods address the characterization of a target protein analyte, which has a dimension greater than an internal diameter of the nanopore tunnel, and which is also physically associated with a polymer. The methods further comprise applying an electrical potential to the nanopore system to cause the polymer to interact with the nanopore tunnel. The ion current through the nanopore is measured to provide a current pattern reflective of the structure of the portion of the polymer interacting with the nanopore tunnel. This is used as a metric for characterizing the associated protein that does not pass through the nanopore.

Abstract: A stripping vessel for removing hydrocarbons from a catalyst and a process for removing hydrocarbons from a catalyst. In an FCC unit, the stripping vessel includes first and second stripping sections. The first stripping section includes at least one grid having a plurality of interesting members and openings therebetween. The second stripping section includes structured packing such as a plurality of ribbons. The one or more grids are spaced from the structured packing, and from each other, so as to minimize the accumulation of catalyst within the stripping vessel, preferably between about 0.91 m (3 ft) to about 1.5 m (5 ft).