Abstract: A footwear system having a plurality of temperature sensors determines the emergence of an ulcer or pre-ulcer on a person's foot. After the plurality of temperature sensors generate a plurality of discrete temperature data values, the system and method form a temperature map representing substantially the actual geometric shape of at least a portion of the foot, and the distribution of temperatures of the at least a portion of the foot. Next, the method and system determine whether the temperature map presents at least one of a plurality of prescribed patterns, and produces output information indicating an emergence of an ulcer or a pre-ulcer on a given portion on the foot. The output information is produced as a function of whether the temperature map is determined to present the at least one of the plurality of prescribed patterns.

Abstract: A method determines the emergence of an ulcer or a pre-ulcer on at least one foot of a patient provides one or more processors and a modality for receiving at least one foot. The method generates, using a plurality of temperature sensors, discrete temperature data values after receipt of the at last one foot. The plurality of discrete temperature data values represents temperatures at different locations of the at least one foot. Next, the method compares, using a prescribed function, each of the discrete temperature data values to one of a plurality of different predetermined values. The predetermined values are different for at least two different locations of the at least one foot. The method then produces output information indicating an emergence of an ulcer or a pre-ulcer on the at least one foot as a result of comparing.

Abstract: A footwear system having a plurality of temperature sensors determines the emergence of an ulcer or pre-ulcer on a person's foot. After the plurality of temperature sensors generate a plurality of discrete temperature data values, the system and method form a temperature map representing substantially the actual geometric shape of at least a portion of the foot, and the distribution of temperatures of the at least a portion of the foot. Next, the method and system determine whether the temperature map presents at least one of a plurality of prescribed patterns, and produces output information indicating an emergence of an ulcer or a pre-ulcer on a given portion on the foot. The output information is produced as a function of whether the temperature map is determined to present the at least one of the plurality of prescribed patterns.

Abstract: The present invention provides pharmaceutical compositions useful in treating hepatitis C infection. The present invention also provides methods of treating hepatitis C infection by administering to a mammal the pharmaceutical compositions of the present invention.

Abstract: The present invention provides pharmaceutical compositions useful in treating hepatitis C infection. The present invention also provides methods of treating hepatitis C infection by administering to a mammal the pharmaceutical compositions of the present invention.

Abstract: The invention is antiobesity/antidiabetic/beta-3 agonists of the formula ##STR1## wherein the substituents R.sub.o, R.sub.1, R.sub.4, R.sub.4 ', R.sub.5, R.sub.6 or n are as defined in the specification.

Abstract: The invention is antiobesity/antidiabetic/beta-3 agonists of the formula ##STR1## wherein the substituents R.sub.o, R.sub.1, R.sub.4, R.sub.4 ', R.sub.5, R.sub.6 or n are as defined in the specification.

Abstract: The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.

Abstract: A process is disclosed for obtaining the R,R isomer of: ##STR1## wherein R.sub.1 and R.sub.2 may be one or more groups which may be the same or different and are selected from the group consisting of hydrogen, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, hydroxy, halogen, trifluoromethyl, carboxy, hydroxyalkyl, alkoxycarbonyl, C.sub.1 to C.sub.4 thioalkyl, sulfonyl and sulfinyl; X is a divalent radical consisting of ##STR2## wherein R' is hydrogen; R.sub.2 and R.sub.3 may be the same or different and are selected from the group consisting of hydrogen and C.sub.1 to C.sub.4 alkyl; R.sub.5 and R.sub.6 are selected from the group consisting of hydrogen, carboxy, alkoxycarbonyl, hydroxymethyl, --CH.sub.2 OCH.sub.2 COOR.sub.7 and --CH.sub.2 OCH.sub.2 CH.sub.2 OR.sub.7 where R.sub.7 is hydrogen or C.sub.1 to .sub.4 alkyl; except that R.sub.5 and R.sub.

Abstract: New thioester and ester, amide and ketone isostere analogs of oleoyl coenzyme A, useful as antiatherosclerotic agents, are provided. The compounds have the formula: ##STR1## wherein A is selected from the group consisting of ##STR2## Y is selected from the group consisting of --S--, --O--, --NH-- and (--CH.sub.2 --).sub.n wherein n=1 to 4; and Z is selected from the group consisting of alkyl (C.sub.1 -C.sub.6), ##STR3## wherein R=Hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.

Abstract: The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.

Abstract: The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.

Abstract: The present invention discloses substituted 1,3-benzodioxoles which possess anti-diabetic and/or anti-hyperglycemic and/or anti-obesity properties in humans and other animals.

Abstract: New thioester and ester, amide and ketone isostere analogs of oleoyl coenzyme A, useful as antiatherosclerotic agents, are provided. The compounds have the formula: ##STR1## wherein A is selected from the group consisting of ##STR2## Y is selected from the group consisting of --S--, --O--, --NH-- and (--CH.sub.2 --).sub.n wherein n=1 to 4; and Z is selected from the group consisting of alkyl (C.sub.1 -C.sub.6), ##STR3## wherein R=Hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.