Abstract: According to the invention there is provided various methods of treating mammalian interstitial cystitis and/or urethral syndrome through the use of Nifedipine, a calcium channel antagonist which has been primarily used for the treatment of coronary artery spasms and hypertension. Specifically, the invention is directed to the adminstration of an therapeutically effective amount of Nifedipine to mammals suffering from interstitial cystitis and/or urethral syndrome. The Nifedipine may be administered in admixture with a pharmaceutically acceptable carrier in a unit dosage form. The route of administration is that deemed preferred by the attending physician, with oral administration being preferred.