Abstract: With optical fiber-based illumination, uniform perceived illumination at an image capture device can be achieved with an input-angle-dependent intensity distribution at the input to the optical fiber. Disclosed are various apparatus and associated methods of operation that achieve such an angular intensity distribution, either statically or via programmable or controllable devices. Example embodiments utilize spatial intensity modulation of the light at a transform plane preceding the input to the optical fiber, light emission by multiple individually controllable emitters at different distances from or different angles relative to an optical axis, and/or beam sweeping across a range of input angles in synchronization with intensity control to generate the desired angular intensity distribution.

Abstract: A method includes forming, by atomic layer deposition, a first barrier layer on a surface of a printed circuit board (“PCB”) and on an outer surface of an electrical component attached to the surface of the PCB; forming an adhesion promotion layer on a surface of the first barrier layer; and forming, on the adhesion promotion layer, a second barrier layer including Parylene.

Abstract: An illustrative system includes first and second electrical circuits, a free space optics interface assembly, and a feedthrough assembly. The free space optics interface assembly may include an optical transmitter having an input that is electrically coupled to the first electrical circuit, and an optical receiver having an output that is electrically coupled to the second electrical circuit. The feedthrough assembly electrically connects the input of the optical transmitter to the first electrical circuit and includes a first conductive receptacle electrically coupled to a first input pin of the optical transmitter, a second conductive receptacle electrically coupled to a second input pin of the optical transmitter, a first conductive pad providing electrical connection of the first input pin of the optical transmitter to the first electrical circuit, and a second conductive pad providing electrical connection of the second input pin of the optical transmitter to the first electrical circuit.

Abstract: An electronic assembly includes a printed circuit board (“PCB”), an electrical component attached to a surface of the PCB, and a conformal barrier disposed on at least a portion of the surface of the PCB and on an outer surface of the electrical component. The conformal barrier includes a first barrier layer including an atomic layer deposited film and a second barrier layer including Parylene.

Abstract: An exemplary medical system includes a first electrical circuit (204-1) on a PCB (206), a second electrical circuit (204-2) on the PCB and electrically isolated from the first electrical circuit, and a free space optics interface assembly (302) on the PCB. The free space optics assembly includes a housing (402) defining a free space chamber (404) in the housing, an optical transmitter (416) having an input (426) that is electrically coupled to the first electrical circuit, and an optical receiver (418) in optical communication with the optical transmitter via the free space chamber and having an output (432) that is electrically coupled to the second electrical circuit. The optical transmitter and the optical receiver are hermetically sealed within the housing.

Abstract: Described herein are devices, systems, and methods for illumination of a target that provide control over the beam divergence, beam shape, and/or direction of the illumination beam. Such illumination beam control may be based on images of the target, and may serve to direct light at one or more regions of interest.

Abstract: A tissue contact detection system tracks, over time during a surgical procedure, a temperature of a surgical instrument associated with a surgical system used for the surgical procedure. The system determines, based on the tracked temperature of the surgical instrument, that the temperature of the surgical instrument changes from a first temperature to a second temperature that varies from the first temperature by at least a predetermined amount, and determines, based on the determination that the temperature of the surgical instrument changes from the first temperature to the second temperature, that the surgical instrument is in physical contact with patient tissue. The system performs, in response to the determination that the surgical instrument is in physical contact with patient tissue, a mitigation operation configured to mitigate the physical contact of the surgical instrument with the patient tissue.

Abstract: An exemplary connection system includes a connector assembly and a receiver assembly. The connector assembly includes a hermetically-sealed housing, a first RF communication device within the housing and communicatively coupled to a surgical instrument and a first induction coil within the housing and electrically coupled to the surgical instrument. The receiver assembly includes a second RF communication device communicatively coupled to a controller of the surgical instrument, a second induction coil electrically coupled to a power source and a receptacle configured to receive the connector assembly such that the first RF communication device is aligned with the second RF communication device, the first induction coil is aligned with the second induction coil, the first RF communication device may wirelessly communicate with the second RF communication device, and the second induction coil may inductively couple to the first induction coil to wirelessly transmit power to the first induction coil.

Abstract: An illumination source may be coupled to an image capture device through a connector. A light sensor is placed downstream of the connector to measure the light received by the image capture device from the illumination source. The light sensor provides the measurement of the received light to the illumination source for closed-loop control of illumination source. The light sensor may be positioned in a camera housing to take into account light attenuation from the illumination source to the camera. The light sensor may be positioned at other locations on the image capture device. Multiple light sensors may be positioned at different locations on the image capture device to detect sources or locations of attenuation. Redundant light sensors of more than one type of sensor may be used at a single light sensor location to provide for validation of measurements and increase the variety of information measured.

Abstract: An image capture unit has mounted in a frame: a first imaging assembly, a first circuit board, a second imaging assembly, and a second circuit board. The first imaging assembly is mounted on the first circuit board. The second imaging assembly is mounted on the second circuit board. A portion of the first circuit board and a portion of the second circuit board have a stacked configuration with the portion of the first circuit board being approximately parallel to the portion of the second circuit board. An end of another portion of the first circuit board is adjacent to an end of another portion of the second circuit board.

Abstract: An exemplary medical system includes a first electrical circuit (204-1) on a PCB (206), a second electrical circuit (204-2) on the PCB and electrically isolated from the first electrical circuit, and a free space optics interface assembly (302) on the PCB. The free space optics assembly includes a housing (402) defining a free space chamber (404) in the housing, an optical transmitter (416) having an input (426) that is electrically coupled to the first electrical circuit, and an optical receiver (418) in optical communication with the optical transmitter via the free space chamber and having an output (432) that is electrically coupled to the second electrical circuit. The optical transmitter and the optical receiver are hermetically sealed within the housing.

Abstract: An electronic assembly includes a printed circuit board (“PCB”), an electrical component attached to a surface of the PCB, and a conformal barrier disposed on at least a portion of the surface of the PCB and on an outer surface of the electrical component. The conformal barrier includes a first barrier layer including an atomic layer deposited film and a second barrier layer including Parylene.

Abstract: A method for creating optical links between two or more optical devices. The method eliminates the need for precision active alignment of the individual components to be joined. After the components to be joined have been bonded in place on a package the optical axis of each component is found and an optical link among the components is fabricated in-place.

Abstract: A method of characterizing an object includes determining a depth-wise composition of the object at a measurement site within the object. A property of the object within a region adjacent to the measurement site can, optionally, be estimated based on the determining. Another method of characterizing an object includes disposing at least a portion of an object within a measurement region of a metrology tool, aligning a feature of the object and a location of a designated measurement site within the measurement region relative to each other, and performing a performing a compositional analysis of a portion of the object occupying the measurement site. Various apparatus for performing these methods are also disclosed, as are methods of monitoring manufacturing processes based on these methods.

Abstract: A method for concentrating and isolating nucleated cells, such as maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.

Abstract: A method for concentrating and isolating nucleated cells, such as a maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.

Abstract: A manufacturing process is applicable to singulating die from a substrate, where the substrate has a layer distinguishable from the substrate by a mechanical property such as brittleness. The process can include providing a workpiece including a substrate and a layer disposed on a first surface, modifying the mechanical property such as by compression, deforming a region of the substrate proximate to the portion of the layer having the modified mechanical property; and fracturing the portion of the layer at a location proximate to the deformed region of the substrate. Also, the process can include propagating a crack through a region of the substrate on a line along the modified portion of the layer. A die formed in this manner is also provided.

Abstract: A light emitting diode is made using a laser to texture the sidewalls of the bottom contact layer, without damaging a mesa. To do so, the substrate is mounted on a laser machining platform, and trenches are cut along lines through the semiconductor layer on the substrate using a first sequence of laser pulses having short pulse lengths that result in formation of textured sidewalls in the trenches, without causing recasting of the material. Then the substrate can be scribed along the lines of the trenches using a second sequence of laser pulses for singulation of die.

Abstract: A method of creating a layer of cells on a surface. In some embodiments, the method includes the steps of engaging a smear tool against the surface with an engagement force; flexing a portion of the smear tool to change an orientation of the smear tool with respect to the surface; moving the smear tool along the surface through a sample comprising cells suspended in a liquid; and adhering the sample to the surface to thereby create a layer of cells. Another method according to the invention creates a layer of cells on a surface by mixing the sample prior to and/or during the smear. The invention also includes systems for implementing the methods.

Abstract: A method for concentrating and isolating nucleated cells, such as a maternal and fetal nucleated red blood cells (NRBC's), in a maternal whole blood sample. The invention also provides methods and apparatus for preparing to analyze and analyzing the sample for identification of fetal genetic material as part of prenatal genetic testing. The invention also pertains to methods and apparatus for discriminating fetal nucleated red blood cells from maternal nucleated red blood cells obtained from a blood sample taken from a pregnant woman.