Abstract: The invention provides methods and compositions for the oral delivery of pharmaceutically active agents. In particular, the compositions generally comprise a plurality of pharmaceutically active agents embedded in a matrix that is substantially erodable when contacted with an aqueous medium. The compositions may also include an inner core comprising an inert material. The compositions may be introduced into the oral cavity of a subject by liquid beverage or food product comprising a composition of the invention.

Abstract: Methods for affecting body composition include the use of amylin or amylin agonist(s). Total body weight may be reduced, maintained or even increased; however, the body fat is reduced or body fat gain is prevented, while lean body mass is maintained or increased.

Abstract: A portable processing device or system may permit a user to access a resource when a certain number of keys are present, according to an authentication policy and a context in which the certain number of keys are provided. In some contexts fewer or no keys may be required, while in other contexts more keys may be required. The authentication policy may be adaptable, such that a precautionary action may be taken when a previously unused combination of keys and a context are used. Further, the authentication policy may require a fewer number of keys close to a time of a last successful authentication and may require a larger number of keys as time passes since the last successful authentication. In some embodiments, a type of visual feedback of entered password text may change based on a security level.

Abstract: Methods for affecting body composition include the use of amylin or amylin agonist(s). Total body weight may be reduced, maintained or even increased; however, the body fat is reduced or body fat gain is prevented, while lean body mass is maintained or increased.

Abstract: The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The subject antibodies may be used to detect HPV E6 protein in a sample, and, accordingly, the antibodies find use in a variety of diagnostic applications, including methods of diagnosing cancer. Kits for performing the subject methods and containing the subject antibodies are also provided.

Abstract: A valve assembly (100) has an inlet port (104) and an outlet port (106) linked by a fluid conduit (102) for allowing fluid to pass therebetween. The valve assembly includes a stop valve having a spindle (112) that is centrally mounted within the valve assembly and a valve head (108) mounted on the spindle (112). The stop valve spindle (112) is operable to move the stop valve head (108) between an open position, in which the inlet port (104) is in communication with the outlet port (106), and a closed position, in which the outlet port is isolated from the inlet port. Also provided is a control valve having at least one spindle (114) that is eccentrically mounted within the valve assembly and a valve head (110) mounted on the at least one control valve spindle (114).

Abstract: Compounds of formula (I): are useful in the treatment of diseases associated with deposition of ?-amyloid in the brain.

Abstract: A composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal includes an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive selected from (i) a pectin and (ii)a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. A method for treating or managing pain by intranasally administering the composition is also disclosed.

Abstract: A pharmaceutical composition comprises clonidine or a pharmaceutically acceptable salt or prodrug thereof. The composition, when administered to a patient in an amount delivering a clonidine dose of about 0.1 to about 2 mg/day, exhibits clonidine release properties providing a 24-hour profile of plasma clonidine concentration that (a) does not substantially or protractedly fall below about 0.2 ng/ml and exhibits a peak concentration that is therapeutically effective and does not cause unacceptable side effects in the patient; and/or (b) exhibits a peak that substantially coincides with or closely anticipates a time of maximum plasma concentration of a catecholamine occurring in a diurnal cycle of a patient having a catecholamine-mediated disease or disorder. A method for treating a disease or disorder for which clonidine is indicated in a patient comprises administering such a composition one to three times daily in a dose of about 0.1 to about 2 mg/day to the patient.

Abstract: This invention relates generally to pharmaceutical compositions for treating seizures, and, more particularly, to pharmaceutical compositions that are bioadherent to oral and/or nasal mucosa, comprise one or more anti-acute seizure agents, and can be used to treat one or more conditions selected from the group consisting of acute seizure, repetitive seizures, and status epilepticus. This invention also relates generally to methods for preparing such compositions, methods of treatment using such compositions, uses of such compositions to prepare medicaments, and kits comprising such compositions.

Abstract: An acousto-optic modulator includes a (100), (010) or (001) single crystal silicon acousto-optic interaction medium, and at least one transducer for emitting an acoustic wave attached to the single crystal. The transducer has a first electrode layer disposed on one side and a second electrode layer disposed on its other side. The transducer is aligned to the single crystal so that the direction of acoustic propagation in the silicon crystal is substantially along the (100), (010) or (001) direction. A q-switched laser includes a modulator according to the invention.

Abstract: This invention relates to inhibitors and modulators of the binding between a transcient receptor potential (TRP) channel protein and a TRP-associated binding protein. In particular inhibitors and modulators of the binding between the TRPM7 channel protein and PDZ-domain containing TRP-associated proteins. These modulators and inhibitors are used to control Ca2+ transport through TRPM7 channel proteins and reduce damage to mammalian cells, including brain and spinal cord cells, after ischemia or traumatic injury.

Abstract: An interface assembly for a sensor array is provided. The interface assembly may be made up of an integrated circuit package thermally coupled to the sensor array. The interface assembly may include a temperature control system for controlling the temperature of the sensor array. The temperature control system includes a temperature sensor for sensing a temperature variation of each sensor of the sensor array from an initial temperature beyond a predetermined threshold. A temperature controller is coupled to each temperature sensor and receives an output signal from the temperature sensor upon the sensor temperature variation exceeding the predetermined threshold. A temperature correction device is coupled to each temperature controller and causes the sensor temperature variation to fall within the predetermined threshold upon receiving a control signal from the temperature controller.

Abstract: Enzymatic and chemical processes for the preparation of certain of 3-phenyl-2-arylalkylthiopropionic acid derivatives which have utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance and other manifestations of the metabolic syndrome are described and also certain novel intermediates used in these processes.

Abstract: Various configurations for scatter reduction and control are provided for CT imaging. These configurations include an imaging system having a stationary detector extending generally around a portion of an imaging volume and a distributed X-ray source placed proximal to the stationary detector for radiating an X-ray beam toward the stationary detector. A scatter control system is further provided that is configured to adaptively operate in cooperation with the stationary detector and the distributed X-ray source to focally align collimator septa contained therein to the X-ray beam at a given focal point and to provide X-ray beam scatter control.

Abstract: The present invention provides compositions and methods for inhibiting the binding of the carboxy-terminus of MUC1 to PDZ domain(s) and to enhance the sensitivity of MUC1 expressing cancer cells to chemotherapeutic agents.

Abstract: A development station in an electrostatographic imaging machine impedes the flow of carrier particles out of the development station as the developer moves from an upper to a lower magnetic roll.

Abstract: A spatial light modulator (SLM) is disclosed that increases speed and efficiency of an SLM through the use of a perforated hinge. The hinge may take many forms, but generally includes an elongated body having holes therein along its longitudinal direction. One or more electrodes are charged with a predetermined voltage in order rotate a reflecting surface towards the electrodes through electrostatic attraction. The perforations within the hinge results in the hinge being made from less material so that it is less sensitive to hinge thickness variations that can occur during the manufacturing process. Consequently, the perforated hinge allows for more stable, uniform mirror rotation.

Abstract: Independent radio communication devices can share network information directly with each other in the local area using an independent wireless link. This network information encompasses synchronisation information, interference, network configuration, neighbour cell list, paging requests, etc., and can be relevant to multiple networks, frequency carriers and/or air interface modes. Sharing the information reduces the processing requirement, the power consumption, and the bandwidth consumption of devices.

Abstract: A detector assembly is presented. The detector assembly includes a first detector layer having a top side and a bottom side, where the first detector layer includes a plurality of first coupling gaps. Additionally, the detector assembly includes a first interconnect structure operationally coupled to the first detector layer and configured to facilitate transfer of a first set of image data from the first detector layer to backplane electronics. The detector assembly also includes a second detector layer having a top side and a bottom side and disposed adjacent the bottom side of the first detector layer, where the second detector layer includes a plurality of second coupling gaps configured to facilitate passage of the first interconnect structure from the first detector layer to the backplane electronics.