Abstract: An automated system of airborne drones may be equipped with components for navigating within a warehouse environment, locating specific bins of product as assigned, retrieving a single item from the bin, and delivering the retrieved item to a central shipping area or disposing in a designated location including conveyor belts or mobile robotic platforms.

Abstract: A mobility vehicle may comprise a frame, a first pivot arm, a second pivot arm, and a suspension assembly. The first pivot arm may be coupled to the frame and coupled to a drive wheel. The second pivot arm may be coupled to the frame and coupled to a ground engaging caster wheel. The suspension assembly may be coupled to the frame. The suspension assembly may include a first spring assembly and a second spring assembly. The first spring assembly may be disposed about a first spring axis and coupled to the first pivot arm. The second spring assembly may be disposed about a second spring axis and coupled to the second pivot arm. The first spring axis and the second spring axis may be disposed relative to each other at an angle of no greater than about 150° when the mobility vehicle is operating on horizontal ground.

Abstract: A shipping package (1) comprises an enclosure for receiving content within, a closure (14) for sealing the enclosure, a label comprising shipping information, a network module (380), a sensor module (382), and a battery module (384). The battery module provides power to the network module and the sensor module. The sensor module (382) providing location information to the network module, the network module transmits a shipping status message to an external device.

Abstract: A mobility vehicle may comprise a frame, a first pivot arm, a second pivot arm, and a suspension assembly. The first pivot arm may be coupled to the frame and coupled to a drive wheel. The second pivot arm may be coupled to the frame and coupled to a ground engaging caster wheel. The suspension assembly may be coupled to the frame. The suspension assembly may include a first spring assembly and a second spring assembly. The first spring assembly may be disposed about a first spring axis and coupled to the first pivot arm. The second spring assembly may be disposed about a second spring axis and coupled to the second pivot arm. The first spring axis and the second spring axis may be disposed relative to each other at an angle of no greater than about 150° when the mobility vehicle is operating on horizontal ground.

Abstract: Disclosed are compositions for targeting 0TUD7A, the compositions having a component sufficient to block and/or reduce OTUD7A-mediated deubiquitination of EWS-FLI1 in a cell. The component can be 7Ai and variants thereof. The compositions can be used to treat Ewing sarcoma (EWS). Methods of using the disclosed compositions are also disclosed, including methods of treating EWS in a subject.

Abstract: A method and a system for monitoring aircraft including at least one server, the method comprising the steps of: receiving, with a receiver, position data from an aircraft; maintaining a database comprising one or more pieces of data corresponding to a landing site; calculating, with a processor, one or more potential vectors of the aircraft based on the received position data and the one or more pieces of data corresponding to the landing site; determining, with the processor, a probability the aircraft is approaching the landing site based on the one or more potential vectors of the aircraft; identifying, with the processor, a potential for conflict between the aircraft and the landing site based on the probability the aircraft is approaching the landing site and the one or more pieces of data corresponding to the landing site; and activating, with a controller, an alert system based on the potential for conflict determined by the processor, wherein activation of the alert system alerts the landing site of

Abstract: Fibronectin type III (10Fn3) binding domains having novel designs that are associated with reduced immunogenicity are provided. The application describes alternative 10Fn3 binding domains in which certain immunogenic regions are not modified when producing a binder in order to maintain recognition as a self antigen by the host organism. The application also describes 10Fn3 binding domains in which HLA anchor regions have been destroyed thereby reducing the immunogenic contribution of the adjoining region. Also provided are 10Fn3 domains having novel combinations of modified regions that can bind to a desired target with high affinity.

Abstract: Aspects of the subject disclosure may include, for example, obtaining a first analysis of first traffic associated with a first communication device, obtaining a second analysis of second traffic associated with a second communication device, identifying, based on the obtaining of the first analysis and the obtaining of the second analysis, a first handicap to be applied to a first connection associated with the first communication device, and applying the first handicap to the first connection. Other embodiments are disclosed.

Abstract: Systems and methods of planning and scheduling resources of an airline include using machine learning models to generate custom behavioral characteristics for a plurality of operational components of the airline based on operations data. The custom behavioral characteristics are used to define inputs and outcomes in simulations of the operational components of the airline. The simulation outputs performance indicators and a feedback loop captures previously ignored interactions between the operational components of the airline based on the performance indicators and custom behavioral characteristics of inputs and outcomes corresponding to the plurality of operational components of the airline.

Abstract: There are provided methods and systems for making or repairing a specified part. For example, there is provided a method for creating an optimized manufacturing process to make or repair the specified part. The method includes receiving data from a plurality of sources, the data including as-designed, as-manufactured, as-simulated, and as-tested data relative to one or more parts similar to the specified part. The method includes updating, in real time, a surrogate model corresponding with a physics-based model of the specified part, wherein the surrogate model forms a digital twin of the specified part. The method includes further updating the surrogate model with a model of manufactured variance associated with at least one of inspection and in-operation data of a similar part. The method includes executing, based on the digital twin, the optimized manufacturing process to either repair or make the specified part.

Abstract: A shipping package (1) comprises an enclosure for receiving content within, a closure (14) for sealing the enclosure, a label comprising shipping information, a network module (380), a sensor module (382), and a battery module (384). The battery module provides power to the network module and the sensor module. The sensor module (382) providing location information to the network module, the network module transmits a shipping status message to an external device.

Abstract: There are provided methods and systems for making or repairing a specified part. For example, there is provided a method for creating an optimized manufacturing process to make or repair the specified part. The method includes receiving data from a plurality of sources, the data including as-designed, as-manufactured, as-simulated, as-inspected, as-operated, and as-tested data relative to one or more parts similar to the specified part. The method includes updating, in real time, a surrogate model corresponding with a physics-based model of the specified part, wherein the surrogate model forms a digital twin of the specified part. The method includes generating a prognostic model of predicted performance of the specified part based on the surrogate model and based on one or more characteristics of at least one of an additive and a reductive manufacturing process. The method includes executing, based on the digital twin, the optimized manufacturing process to either repair or make the specified part.

Abstract: There are provided methods and systems for making or repairing a specified part. For example, there is provided a method for creating a manufacturing process to make or repair the specified part. The method includes receiving data from a plurality of sources, the data including as-designed, as-manufactured, as-simulated, as-operated, as-inspected, and as-tested data relative to one or more parts similar to the specified part. The method includes updating, in real time, a surrogate model corresponding with a physics-based model of the specified part, wherein the surrogate model forms a digital twin of the specified part. The method includes generating a multi-variant distribution including component performance and manufacturing variance, the manufacturing variance being associated with at least one of an additive manufacturing process step and a reductive manufacturing process step.

Abstract: A shipping package (1) comprises an enclosure for receiving content within, a closure (14) for sealing the enclosure, a label comprising shipping information, a network module (380), a sensor module (382), and a battery module (384). The battery module provides power to the network module and the sensor module. The sensor module (382) providing location information to the network module, the network module transmits a shipping status message to an external device.

Abstract: The disclosed inventions include personal Unmanned Aerial Vehicles (UAV's) and UAV universal docking ports “docking ports” to be incorporated into and/or attached to headwear, including helmets, hard hats and hats and face masks, as well as footwear including boots and shoes, clothing and outerwear, devices, gear and equipment, land, air, water and space vehicles, buildings, wireless towers and other mobile or stationary objects and surfaces referred to collectively as “docking stations”. A docking station may have one or more docking ports for docking, networking and charging or refueling compact personal UAVs, and for providing data communications between said UAVs and other electronic devices that remain with the person while the UAV is in flight or driving or landed on terrain. Said docking ports may also incorporate wireless power transmission for remote wireless charging of one or more UAV's.

Abstract: A mobility vehicle may comprise a frame, a first pivot arm, a second pivot arm, and a suspension assembly. The first pivot arm may be coupled to the frame and coupled to a drive wheel. The second pivot arm may be coupled to the frame and coupled to a ground engaging caster wheel. The suspension assembly may be coupled to the frame. The suspension assembly may include a first spring assembly and a second spring assembly. The first spring assembly may be disposed about a first spring axis and coupled to the first pivot arm. The second spring assembly may be disposed about a second spring axis and coupled to the second pivot arm. The first spring axis and the second spring axis may be disposed relative to each other at an angle of no greater than about 150° when the mobility vehicle is operating on horizontal ground.

Abstract: A system and method for an adaptive graphic user interface (AGUI) (501) that can identify the characteristics of one or more users and display candidates and dynamically select display content and generate an interface (502-506 . . . ) customized to one or more users and display candidates and dynamically arrange, modify, map and adapt an AGUI display to any object (350,730), device, clothing, equipment, furniture, appliance, room, building, vehicle, person, or other passive or active display surface, screen, space or other display candidate and embodiments of an AGUI apparatus (500) that can network, coordinate and/or operate with the AGUI platform (1302) to identify one or more users and display candidates and enabling one or more users to interface with a single AGUI display across multiple display candidates.

Abstract: A system and method for an adaptive graphic user interface (AGUI) (501) that can identify the characteristics of one or more users and display candidates and dynamically select display content and generate an interface (502-506 . . . ) customized to one or more users and display candidates and dynamically arrange, modify, map and adapt an AGUI display to any object (350,730), device, clothing, equipment, furniture, appliance, room, building, vehicle, person, or other passive or active display surface, screen, space or other display candidate and embodiments of an AGUI apparatus (500) that can network, coordinate and/or operate with the AGUI platform (1302) to identify one or more users and display candidates and enabling one or more users to interface with a single AGUI display across multiple display candidates.

Abstract: A system and method for an adaptive graphic user interface (AGUI) (501) that can identify the characteristics of one or more users and display candidates and dynamically select display content and generate an interface (502-506 . . . ) customized to one or more users and display candidates and dynamically arrange, modify, map and adapt an AGUI display to any object (350,730), device, clothing, equipment, furniture, appliance, room, building, vehicle, person, or other passive or active display surface, screen, space or other display candidate and embodiments of an AGUI apparatus (500) that can network, coordinate and/or operate with the AGUI platform (1302) to identify one or more users and display candidates and enabling one or more users to interface with a single AGUI display across multiple display candidates.

Abstract: Fibronectin type III (10Fn3) binding domains having novel designs that are associated with reduced immunogenicity are provided. The application describes alternative 10Fn3 binding domains in which certain immunogenic regions are not modified when producing a binder in order to maintain recognition as a self antigen by the host organism. The application also describes 10Fn3 binding domains in which HLA anchor regions have been destroyed thereby reducing the immunogenic contribution of the adjoining region. Also provided are 10Fn3 domains having novel combinations of modified regions that can bind to a desired target with high affinity.