Patents by Inventor Jonathan Eiseman Bronson

Jonathan Eiseman Bronson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell-mediated directed evolution
    Patent number: 9169481
    Abstract: The present invention relates to systems which harness the molecular biology of a living cell to direct evolution of biological entities of interest. According to the invention, a host cell is engineered to facilitate mutation of a nucleic acid target corresponding to that entity and select for desirable mutants. As applied to populations of host cells, the invention provides a means to generate and contemporaneously select mutants of interest, allowing for the production of extremely diverse libraries enriched in the most ‘fit’ mutants.
    Type: Grant
    Filed: January 5, 2009
    Date of Patent: October 27, 2015
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Virginia W. Cornish, Pamela P. Perlata-Yahya, Jonathan Eiseman Bronson
  • Cell-Mediated Directed Evolution
    Publication number: 20090209038
    Abstract: The present invention relates to systems which harness the molecular biology of a living cell to direct evolution of biological entities of interest. According to the invention, a host cell is engineered to facilitate mutation of a nucleic acid target corresponding to that entity and select for desirable mutants. As applied to populations of host cells, the invention provides a means to generate and contemporaneously select mutants of interest, allowing for the production of extremely diverse libraries enriched in the most ‘fit’ mutants.
    Type: Application
    Filed: January 5, 2009
    Publication date: August 20, 2009
    Inventors: Virginia W. Cornish, Pamela P. Peralta-Yahya, Jonathan Eiseman Bronson