Abstract: Aspects of the disclosure provide for controlling an autonomous vehicle to enter a driveway. As an example, an instruction to pickup or drop off a passenger at a location may be received. It may be determined that the vehicle is arriving in a lane on an opposite side of a street as the location, the lane having a traffic direction opposite to a traffic direction of a lane adjacent to the location. A difficulty score to maneuver the vehicle to the lane adjacent to the location may be determined, and the difficulty score may be compared to a predetermined difficulty score. Based on the comparison, it may be determined to an available driveway on the same side of the street as the location. The vehicle may be controlled to enter the available driveway.

Abstract: The present invention includes compositions and methods for treating heart disease and/or heart failure. In one embodiment, the treatment includes administering to the subject a cell genetically modified to express a chimeric antigen receptor (CAR), comprising an antigen binding domain specific for fibroblast activation protein (FAP). In another embodiment, the treatment includes administering a cell genetically modified to express a T cell receptor (TCR) specific for an activated fibroblast.

Abstract: The present invention includes compositions and methods for treating heart disease and/or heart failure. In one embodiment, the treatment includes administering to the subject a cell genetically modified to express a chimeric antigen receptor (CAR), comprising an antigen binding domain specific for fibroblast activation protein (FAP). In another embodiment, the treatment includes administering a cell genetically modified to express a T cell receptor (TCR) specific for an activated fibroblast.

Abstract: The present invention relates to compositions and methods for T cell targeted delivery of nucleoside modified mRNA molecules encoding agents for the treatment and prevention of fibrosis, cardiac disease, and diseases and disorders associated therewith.

Abstract: A sensor assembly for monitoring any fluid accumulation, temperature, and other properties, characteristics and conditions of the fluid in the dry portion of a life safety fire sprinkler system. The sensor assembly includes a sensor receptacle, an initial fluid level accumulation sensor, a fluid temperature sensor, and at least one upper fluid level accumulation sensor. The sensor assembly can transmit data in real time through a transmitter assembly to a controller and based upon programmed criteria and interact in real time, with other devices. For example, if the sensor assembly detects an amount of condensed fluid in the system and a temperature of the condensed fluid is below a programmed value (e.g., ?38.0° F.), the system can send an alarm in real time that the system could be experiencing a potential fluid freezing event which could be detrimental to the sprinkler system.

Abstract: A system and method for close range object tracking are described. Close range depth images of a user's hands and fingers or other objects are acquired using a depth sensor. Using depth image data obtained from the depth sensor, movements of the user's hands and fingers or other objects are identified and tracked, thus permitting the user to interact with an object displayed on a screen, by using the positions and movements of his hands and fingers or other objects.

Abstract: The present invention includes compositions and methods for treating heart disease and/or heart failure. In one embodiment, the treatment includes administering to the subject a cell genetically modified to express a chimeric antigen receptor (CAR), comprising an antigen binding domain specific for fibroblast activation protein (FAP). In another embodiment, the treatment includes administering a cell genetically modified to express a T cell receptor (TCR) specific for an activated fibroblast.

Abstract: A system and method for close range object tracking are described. Close range depth images of a user's hands and fingers or other objects are acquired using a depth sensor. Using depth image data obtained from the depth sensor, movements of the user's hands and fingers or other objects are identified and tracked, thus permitting the user to interact with an object displayed on a screen, by using the positions and movements of his hands and fingers or other objects.

Abstract: A system and method for close range object tracking are described. Close range depth images of a user's hands and fingers or other objects are acquired using a depth sensor. Using depth image data obtained from the depth sensor, movements of the user's hands and fingers or other objects are identified and tracked, thus permitting the user to interact with an object displayed on a screen, by using the positions and movements of his hands and fingers or other objects.

Abstract: The present invention provides methods of ameliorating or reducing the extent of cardiac arrhythmia disorders, by administering an inhibitor of histone deacetylase enzyme (HDAC).

Abstract: A sensor assembly having a sensor reservoir with probe for fire sprinkler and other systems to monitor and measure the internal characteristics of a pipe system wherein the sensor reservoir is directly connected to the pipe system, allowing the sensor reservoir to fill with the fluid contents of that system and to have a probe be in direct contact with the fluid contents of that system without altering the fluid flow dynamic within the piped system. The probe can transmit data to a controller and, based upon programmed criteria, interact with other devices, e.g., if the temperature probe reports a low temperature of the internal fluid characteristics, the controller can activate a heater linked to the controller so that pipes or sprinkler heads will be further resistant to freezing or other compromising conditions.

Abstract: The present invention provides methods for dilating the bronchi or bronchioles and relaxing a pulmonary smooth muscle in a subject by treating the subject with a pharmaceutical composition, which includes a Histone deacetylase (HDAC) inhibitor. The ability to dilate the bronchi or bronchioles and relax a pulmonary smooth muscle according to the methods of the invention allows treating, alleviating, or inhibiting bronchoconstrictive diseases or disorders and symptoms associated or derived from bronchoconstrictive diseases.

Abstract: A system and method for close range object tracking are described. Close range depth images of a user's hands and fingers or other objects are acquired using a depth sensor. Using depth image data obtained from the depth sensor, movements of the user's hands and fingers or other objects are identified and tracked, thus permitting the user to interact with an object displayed on a screen, by using the positions and movements of his hands and fingers or other objects.

Abstract: The present invention provides methods of ameliorating or reducing the extent of cardiac arrhythmia disorders, by administering an inhibitor of histone deacetylase enzyme (HDAC).

Abstract: The present invention provides methods for dilating the bronchi or bronchioles and relaxing a pulmonary smooth muscle in a subject by treating the subject with a pharmaceutical composition, which includes a Histone deacetylase (HDAC) inhibitor. The ability to dilate the bronchi or bronchioles and relax a pulmonary smooth muscle according to the methods of the invention allows treating, alleviating, or inhibiting bronchoconstrictive diseases or disorders and symptoms associated or derived from bronchoconstrictive diseases.

Abstract: The present invention provides methods of ameliorating or reducing the extent of ischemic injury, reperfusion injury, and myocardial infarction, by administering an inhibitor of histone deacetylase enzyme (HDAC) or an inhibitor of DNA methyltransferase enzyme (DNMT).

Abstract: The present invention provides methods of ameliorating or reducing the extent of ischemic injury, reperfusion injury, and myocardial infarction, by administering an inhibitor of histone deacetylase enzyme (HDAC) or an inhibitor of DNA methyltransferase enzyme (DNMT).

Abstract: A spool has a cylinder, a first flange coupled to a first end of the cylinder and a second flange coupled to a second end of the cylinder. A compressible material surrounds the cylinder and an optical fiber is wrapped around the compressible material. When tension is applied to the optical fiber the compressible material can be deformed to reduce the tension on the optical fiber. When submerged underwater the water pressure will not compress the compressible material.

Abstract: The present invention provides methods of ameliorating or reducing the extent of ischemic injury, reperfusion injury, and myocardial infarction, by administering an inhibitor of histone deacetylase enzyme (HDAC) or an inhibitor of DNA methyltransferase enzyme (DNMT).

Abstract: Various data source locations storing files can be accessed and/or crawled. At each location, files can be identified. These files can be analyzed to obtain attributes characterizing such file. Thereafter, a visualization can be generated in a graphical user interface that takes the form of data map that characterizes the identified files along two or more dimensions, with each dimension being based on a different attribute of the file. For example, the vertical dimension can be based on a number of columns and the horizontal dimension can be based on a number of rows. The graphical user interface can include graphical user interface elements associated with each identified file. These elements, when activated, can cause complementary information characterizing the corresponding identified file to be displayed. The elements can then be used to import or otherwise utilize one of the identified files into an application (such as a spreadsheet software application.