Abstract: A method of increasing the efficacy of treatment for a patient suffering from urothelial carcinoma. The method comprises the steps of determining the presence or absence in a biological sample from the patient of somatic ERCC2 mutation followed by performing appropriate treatment. The absence of somatic ERCC2 mutation indicates that the urothelial carcinoma is likely to be unresponsive to cisplatin chemotherapy, and the patient then undergoes surgery to remove the carcinoma without accompanying cisplatin chemotherapy. The presence of somatic ERCC2 mutation indicates that the uroethelial carcinoma is likely to be responsive to cisplatin chemotherapy and the patient then undergoes surgery to remove the carcinoma accompanied by cisplatin chemotherapy.

Abstract: The disclosure describes a system for applying custom branded tape to packages that are shipped from a multi-seller materials handling facility. In some implementations, a materials handling facility may store, process and ship items for multiple sellers. As items are packed for shipping, a tape dispensing device may dispense custom branded tape associated with the seller of the item(s) being packed such that the sellers brand, logo or other information is presented on the exterior of the container.