Patents by Inventor Jonathan F. Hester
Jonathan F. Hester has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240131450Abstract: A charged depth filter for removing cells and/or cellular debris from a biopharma feedstock having a first functionalized nonwoven layer having a first calculated pore size and a first dynamic charge capacity; a second functionalized nonwoven layer having a second calculated pore size and a second dynamic charge capacity positioned after the first functionalized nonwoven layer in the direction of the biopharma feedstock flow, and wherein the first calculated pore size is greater than the second calculated pore size, and the first dynamic charge capacity is less than the second dynamic charge capacity.Type: ApplicationFiled: February 24, 2022Publication date: April 25, 2024Inventors: Kuan-Yin LIN, Andrew W. VAIL, Daniel J. O'NEAL, Masayuki NAKAMURA, Jonathan F. HESTER, Kannan DASHARATHI, Alexei M. VOLOSHIN
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Publication number: 20230226464Abstract: A chromatography device having a housing having an inlet and an outlet. At least two layers of media disposed between the inlet and the outlet inside of the housing forming a media stack, and wherein at least one of the layers comprises a functionalized layer. A spacer ring disposed between at the least two layers of media forming an air gap between them.Type: ApplicationFiled: April 27, 2021Publication date: July 20, 2023Inventors: Kannan DASHARATHI, Jonathan F. HESTER, Gregory M. JELLUM, Angelines CASTRO FORERO
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Publication number: 20230227496Abstract: Flow-through processes for purifying a target molecule (e.g., antibodies, enzymes, and hormones, particularly a monoclonal antibody) from a biological solution (e.g., a neutralized viral inactivation pool) in a sample that includes the target molecule, and devices for carrying out such processes.Type: ApplicationFiled: April 1, 2021Publication date: July 20, 2023Inventors: Andrew W. VAIL, Semra COLAK ATAN, Jerald K. RASMUSSEN, Alexei M. VOLOSHIN, Jonathan F. HESTER
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Publication number: 20230182039Abstract: A chromatography device having a housing having an inlet and an outlet. At least two layers of media disposed between the inlet and the outlet inside of the housing forming a media stack, with at least one of the layers comprising a functionalized layer. An optional spacer ring disposed between the two layers of media forming an air gap between them. A non-functionalized sealing layer disposed between the inlet and the outlet inside of the housing as the last layer of media in the media stack within the housing as a fluid passes from the inlet to the outlet through the media stack. A margin of the sealing layer in contact with the housing; the margin being compressed by the housing forming a compressive seal to prevent fluid from leaking to the outlet past the compressive seal.Type: ApplicationFiled: April 22, 2021Publication date: June 15, 2023Inventors: Kannan DASHARATHI, Jonathan F. HESTER, Gregory M. JELLUM, Angelines CASTRO FORERO
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Publication number: 20210396725Abstract: Described herein is method for testing an ion exchange chromatography device. The method includes monitoring both a binding and a non-binding species and determining their breakthrough point to determine a net breakthrough value. The method can be used to determine the integrity of the chromatography device, ensure that the chromatography device possesses the expected adsorbent capacity, and/or determine viral clearance of the chromatography device.Type: ApplicationFiled: December 16, 2019Publication date: December 23, 2021Inventors: Jonathan F. Hester, Eric J. Olson, Francis E. Porbeni, Andrew W. Vail, Alexei M. Voloshin
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Patent number: 10722848Abstract: Described herein is a filtration media comprising: (i) a first filtration medium comprising an anion exchange nonwoven substrate, wherein the anion exchange nonwoven substrate comprises a plurality of quaternary ammonium groups; and (ii) a second filtration medium comprising a functionalized microporous membrane wherein the functionalized microporous membrane comprises a plurality of guanidyl groups; wherein the first filtration medium is positioned upstream of the second filtration medium.Type: GrantFiled: October 11, 2016Date of Patent: July 28, 2020Assignee: 3M Innovative Properties CompanyInventors: Jonathan F. Hester, Angelines A. Castro Forero, Gregory M. Jellum, Jerald K. Rasmussen, Kannan Seshadri, Clinton P. Waller, Jr.
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Patent number: 10562997Abstract: A method of purifying a biological composition includes: disposing loose cationic ligand-functionalized staple fibers and a biological composition within a mixing volume of a vessel; agitating the biological composition and the loose cationic ligand-functionalized staple fibers while they are in intimate contact with each other within the mixing volume to provide modified fibers and a purified biological composition; and separating at least a portion of the purified biological composition from the modified fibers and any loose cationic ligand-functionalized staple fibers with which it is in contact. The loose cationic ligand-functionalized staple fibers have a modified surface layer comprising a grafted acrylic polymer comprising 10 to 100 percent by weight of a cationically-ionizable monomer unit. An article for purifying a biological composition includes: a vessel having a mixing volume disposed therein; and the loose cationic ligand-functionalized staple fibers disposed within the mixing volume.Type: GrantFiled: March 17, 2016Date of Patent: February 18, 2020Assignee: 3M Innovative Properties CompanyInventors: Andrew W. Vail, Jerald K. Rasmussen, John J. Schmidt, Ali E. Ozcam, Jonathan F. Hester, Gregory M. Jellum
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Patent number: 10406485Abstract: The present disclosure provides methods for forming asymmetric membranes. More specifically, methods are provided for applying a polymerizable species to a porous substrate for forming a coated porous substrate. The coated porous substrate is exposed to an ultraviolet radiation source having a peak emission wavelength less than 340 nm to polymerize the polymerizable species forming a polymerized material retained within the porous substrate so that the concentration of polymerized material is greater at the first major surface than at the second major surface.Type: GrantFiled: August 11, 2017Date of Patent: September 10, 2019Assignee: 3M Innovative Properties CompanyInventors: Jinsheng Zhou, Jonathan F. Hester, Derek J. Dehn, Daniel P. Meehan, Robin E. Wright
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Patent number: 10240013Abstract: Microporous material having a spherulitic matrix made from ethylene chlorotrifluoroethylene copolymer has a plurality of pores having an average pore size greater than about 0.01 micrometer. The material is made by thermally induced phase separation (TIPS) process that includes melt mixing ethylene chlorotrifluoroethylene copolymer, diluent and nucleating agent to provide a melt mixed composition; shaping the melt mixed composition; cooling the shaped melt mixed composition to induce phase separation of the ethylene chlorotrifluoroethylene copolymer to provide a phase separated material; and stretching the phase separated material to provide the microporous material. The microporous material may be incorporated into articles and the articles may include one, two or more layers of microporous material.Type: GrantFiled: December 14, 2009Date of Patent: March 26, 2019Assignee: 3M INNOVATIVE PROPERTIES COMPANYInventors: James S. Mrozinski, Randall P. Swenson, Karl-Dieter Weilandt, Jonathan F. Hester
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Publication number: 20180257042Abstract: Described herein is a filtration media comprising: (i) a first filtration medium comprising an anion exchange nonwoven substrate, wherein the anion exchange nonwoven substrate comprises a plurality of quaternary ammonium groups; and (ii) a second filtration medium comprising a functionalized microporous membrane wherein the functionalized microporous membrane comprises a plurality of guanidyl groups; wherein the first filtration medium is positioned upstream of the second filtration medium.Type: ApplicationFiled: October 11, 2016Publication date: September 13, 2018Inventors: Jonathan F. Hester, Angelines A. Castro Forero, Gregory M. Jellum, Jerald K. Rasmussen, Kannan Seshadri, Clinton P. Waller, Jr.
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Publication number: 20180066095Abstract: A method of purifying a biological composition includes: disposing loose cationic ligand-functionalized staple fibers and a biological composition within a mixing volume of a vessel; agitating the biological composition and the loose cationic ligand-functionalized staple fibers while they are in intimate contact with each other within the mixing volume to provide modified fibers and a purified biological composition; and separating at least a portion of the purified biological composition from the modified fibers and any loose cationic ligand-functionalized staple fibers with which it is in contact. The loose cationic ligand-functionalized staple fibers have a modified surface layer comprising a grafted acrylic polymer comprising 10 to 100 percent by weight of a cationically-ionizable monomer unit. An article for purifying a biological composition includes: a vessel having a mixing volume disposed therein; and the loose cationic ligand-functionalized staple fibers disposed within the mixing volume.Type: ApplicationFiled: March 17, 2016Publication date: March 8, 2018Inventors: Andrew W. Vail, Jerald K. Rasmussen, John J. Schmidt, Ali E. Ozcam, Jonathan F. Hester, Gregory M. Jellum
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Publication number: 20170341031Abstract: The present disclosure provides methods for forming asymmetric membranes. More specifically, methods are provided for applying a polymerizable species to a porous substrate for forming a coated porous substrate. The coated porous substrate is exposed to an ultraviolet radiation source having a peak emission wavelength less than 340 nm to polymerize the polymerizable species forming a polymerized material retained within the porous substrate so that the concentration of polymerized material is greater at the first major surface than at the second major surface.Type: ApplicationFiled: July 31, 2017Publication date: November 30, 2017Inventors: Jinsheng Zhou, Jonathan F. Hester, Derek J. Dehn, Daniel P. Meehan, Robin E. Wright
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Publication number: 20170341032Abstract: The present disclosure provides methods for forming asymmetric membranes. More specifically, methods are provided for applying a polymerizable species to a porous substrate for forming a coated porous substrate. The coated porous substrate is exposed to an ultraviolet radiation source having a peak emission wavelength less than 340 nm to polymerize the polymerizable species forming a polymerized material retained within the porous substrate so that the concentration of polymerized material is greater at the first major surface than at the second major surface.Type: ApplicationFiled: August 11, 2017Publication date: November 30, 2017Inventors: Jinsheng Zhou, Jonathan F. Hester, Derek J. Dehn, Daniel P. Meehan, Robin E. Wright
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Patent number: 9821276Abstract: A functionalized nonwoven substrate and methods for preparing the same are described. The functionalized substrates are useful in selectively filtering and removing biological materials, such as biocontaminates, from biological samples.Type: GrantFiled: February 26, 2013Date of Patent: November 21, 2017Assignee: 3M Innovative Properties CompanyInventors: Michael R. Berrigan, Jonathan F. Hester, Clinton P. Waller, Jr., Douglas E. Weiss
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Patent number: 9751050Abstract: The present disclosure provides methods for forming asymmetric membranes. More specifically, methods are provided for applying a polymerizable species to a porous substrate for forming a coated porous substrate. The coated porous substrate is exposed to an ultraviolet radiation source having a peak emission wavelength less than 340 nm to polymerize the polymerizable species forming a polymerized material retained within the porous substrate so that the concentration of polymerized material is greater at the first major surface than at the second major surface.Type: GrantFiled: May 13, 2009Date of Patent: September 5, 2017Assignee: 3M Innovative Properties CompanyInventors: Jinsheng Zhou, Jonathan F. Hester, Derek J. Dehn, Daniel P. Meehan, Robin E. Wright
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Publication number: 20160317976Abstract: A porous membrane that includes a first zone, the first zone including a crystallizable polymer; and a first nucleating agent, the first nucleating agent having a first concentration in the first zone, the first zone having a first average pore size; and a second zone, the second zone including a crystallizable polymer; and a second nucleating agent, the second nucleating agent having a second concentration in the second zone, the second zone having a second average pore size, wherein the crystallizable polymer is the same in the first zone and second zone, wherein the first average pore size is not the same as the second average pore size, wherein the first nucleating agent and the second nucleating agent are the same or different, wherein the first concentration and the second concentration agent are the same or different and with the proviso that the first nucleating agent and the first concentration are not the same as the second nucleating agent and the second concentration.Type: ApplicationFiled: July 11, 2016Publication date: November 3, 2016Inventors: Jonathan F. Hester, James S. Mrozinski, Derek J. Dehn
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Patent number: 9415350Abstract: The present disclosure provides rewettable asymmetric membranes and methods of forming rewettable asymmetric membranes. More specifically, methods are provided for forming rewettable asymmetric membranes having a copolymer and a polymerized material retained within the porous substrate.Type: GrantFiled: May 13, 2009Date of Patent: August 16, 2016Assignee: 3M Innovative Properties CompanyInventors: Jinsheng Zhou, Jonathan F. Hester, Derek J. Dehn, Daniel P. Meehan, Robin E. Wright
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Publication number: 20150343388Abstract: Described herein is a construction comprising (a) a support sheet having a base, comprising (i) a plurality of rails extending from the base wherein each rail of the plurality of rails extends continuously down a length of the support sheet and each rail comprises a first side surface and an opposing second side surface and a top surface; and (ii) a plurality of first protrusions extending from the base, wherein the plurality of first protrusions are located between the plurality of rails; and (b) a selectively permeable membrane having a first major membrane surface contacting at least the top surface of at least two rails enclosing a flow channel having a height extending between the base of the support sheet and the first major membrane surface, wherein the plurality of protrusions change the height of the flow channel along its length along the longitudinal axis of the flow channel.Type: ApplicationFiled: December 13, 2013Publication date: December 3, 2015Inventors: Jonathan F. Hester, Gustavo H. Castro, Thomas Herdtle, Liming Song
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Publication number: 20150314241Abstract: Described herein is a construction comprising (a) a support sheet having a base, comprising (i) a plurality of rails extending from the base wherein each rail of the plurality of rails extends continuously down a length of the support sheet and each rail comprises a first side surface and an opposing second side surface and a top surface; and (ii) a plurality of first protrusions extending from the base, wherein the plurality of first protrusions are located between the plurality of rails; and (b) a selectively permeable membrane having a first major membrane surface contacting at least the top surface of at least two rails enclosing a flow channel having a height extending between the base of the support sheet and the first major membrane surface, wherein the plurality of protrusions change the height of the flow channel along its length along the longitudinal axis of the flow channel.Type: ApplicationFiled: November 22, 2013Publication date: November 5, 2015Applicant: 3M INNOVATIVE PROPERTIES COMPANYInventors: Jonathan F. Hester, Gustavo H. Castro, Thomas Herdtle, Jimmy M. Le, Liming Song
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Publication number: 20150273405Abstract: Described herein is a membrane separation module and articles and methods thereof, wherein the membrane separation module has a series of repeating layers, each layer comprising (a) a selectively permeable membrane; and (b) at least one support layer, wherein the support layer comprises a plurality of flow channels and a plurality of rails extending from the support layer, wherein the sides of two adjacent rails form a flow channel, wherein the plurality of rails on the support layer comprise a thermoplastic polymer at the distal end of at least a portion of the plurality of rails, and wherein the distal end of the plurality of rails contacts the selectively permeable membrane to form a bonded stack.Type: ApplicationFiled: September 17, 2013Publication date: October 1, 2015Inventors: John W. Henderson, Brady P. Haislet, Brent R. Hansen, Jonathan F. Hester, Gregory M. Jellum, Qihong Nie, John F. Reed, John B. Scheibner, David F. Slama, Steven E. Turch