Patents by Inventor Jonathan F. Lawrence

Jonathan F. Lawrence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrolides with Modified Desosamine Sugars and Uses Thereof
    Publication number: 20230242565
    Abstract: Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. The disclosed macrolides may have a bicyclic structure. Also provided are pharmaceutical compositions and methods of treating infectious diseases, and in particular, disease which results from Gram negative bacteria using the disclosed macrolides. This disclosure additionally provides methods of preparing the macrolides by a strategy that enables late-stage modification of the 6?-position of the sugar moiety, thereby allowing facile access to previously difficult-to-make macrolide compounds.
    Type: Application
    Filed: April 4, 2023
    Publication date: August 3, 2023
    Inventors: Andrew G. Myers, Ziyang Zhang, Takehiro Fukuzaki, Udara Anulal Premachandra Ilandari Dewage, Senkara Rao Allu, Roger B. Clark, Jonathan F. Lawrence, Wesley Francis Austin, Xiben Li, Wenying Wang, Sushmita D. Lahiri, Yoshitaka Ichikawa
  • Macrolides with modified desosamine sugars and uses thereof
    Patent number: 11673910
    Abstract: Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. The disclosed macrolides may have a bicyclic structure. Also provided are pharmaceutical compositions and methods of treating infectious diseases, and in particular, disease which results from Gram negative bacteria using the disclosed macrolides. This disclosure additionally provides methods of preparing the macrolides by a strategy that enables late-stage modification of the 6?-position of the sugar moiety, thereby allowing facile access to previously difficult-to-make macrolide compounds.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: June 13, 2023
    Inventors: Andrew G. Myers, Ziyang Zhang, Takehiro Fukuzaki, Udara Anulal Premachandra Ilandari Dewage, Senkara Rao Allu, Roger B. Clark, Jonathan F. Lawrence, Wesley Francis Austin, Xiben Li, Wenying Wang, Sushmita D. Lahiri, Yoshitaka Ichikawa
  • C10-Alkylene Substituted 13-Membered Macrolides and Uses Thereof
    Publication number: 20230093692
    Abstract: Provided are 13-membered macrolides for the treatment of infectious diseases. The 13-membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13-membered macrolides, and methods of treating infectious diseases, and in particular, disease resulting from Gram negative bacteria using the disclosed macrolides.
    Type: Application
    Filed: November 18, 2019
    Publication date: March 23, 2023
    Inventors: Roger B. Clark, Richard Alm, Wesley Francis Austin, Hogan Philip, Ivan Jewett, Sushmita D. Lahiri, Jonathan F. Lawrence, Xiben Li, Shuhao Shi, Wenying Wang, Yoshitaka Ichikawa, Andrew G. Myers, Ziyang Zhang, Peter Niels Carlsen, Andre Sanchez, Ganapathy Dhandapani, Thrimurtulu Neetipalli, Md. Ataur Rahman, Thomas Lepitre
  • Macrolides with Modified Desosamine Sugars and Uses Thereof
    Publication number: 20220306673
    Abstract: Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. The disclosed macrolides may have a bicyclic structure. Also provided are pharmaceutical compositions and methods of treating infectious diseases, and in particular, disease which results from Gram negative bacteria using the disclosed macrolides. This disclosure additionally provides methods of preparing the macrolides by a strategy that enables late-stage modification of the 6?-position of the sugar moiety, thereby allowing facile access to previously difficult-to-make macrolide compounds.
    Type: Application
    Filed: April 27, 2018
    Publication date: September 29, 2022
    Inventors: Andrew G. Myers, Ziyang Zhang, Takehiro Fukuzaki, Udara Anulal Premachandra llandari Dewage, Senkara Rao Allu, Roger B. Clark, Jonathan F. Lawrence, Wesley Francis Austin, Xiben Li, Wenying Wang, Sushmita D. Lahiri, Yoshitaka Ichikawa
  • C10-Cyclic Substituted 13-Membered Macrolides and Uses Thereof
    Publication number: 20220177508
    Abstract: Provided are 13-membered macrolides for the treatment of infectious diseases. The 13-membered macrolides described herein are azaketolides. Also provided are methods for preparing the 13-membered macrolides, pharmaceutical compositions comprising the 13-membered macrolides, and methods of treating infectious diseases, and in particular, disease resulting from Gram negative bacteria using the disclosed macrolides.
    Type: Application
    Filed: November 18, 2019
    Publication date: June 9, 2022
    Inventors: Roger B. Clark, Richard Alm, Wesley Francis Austin, Vijaya Gondi, Philip Hogan, Ivan Jewett, Sushmita D. Lahiri, Jonathan F. Lawrence, Xiben Li, Shuhao Shi, Wenying Wang, Yoshitaka Ichikawa, Andrew G. Myers, Ziyang Zhang, Peter Niels Carlsen, Md. Ataur Rahman