Patents by Inventor Jonathan Feld
Jonathan Feld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10451402Abstract: The present invention relates to a full-field reflection phase microscope. In a preferred embodiment, the invention can combine low-coherence interferometry and off-axis digital holographic microscopy (DHM). The reflection-based DHM provides highly sensitive and a single-shot imaging of cellular dynamics while the use of low coherence source provides a depth-selective measurement. A preferred embodiment of the system uses a diffraction grating in the reference arm to generate an interference image of uniform contrast over the entire field-of-view albeit low-coherence light source. With improved path-length sensitivity, the present invention is suitable for full-field measurement of membrane dynamics in live cells with sub-nanometer-scale sensitivity.Type: GrantFiled: January 25, 2012Date of Patent: October 22, 2019Assignees: Massachusetts Institute of Technology, Hamamatsu Photonics K.K.Inventors: Zahid Yaqoob, Wonshik Choi, Toyohiko Yamauchi, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
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Patent number: 9662047Abstract: The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.Type: GrantFiled: June 23, 2011Date of Patent: May 30, 2017Assignee: Massachusetts Institute of TechnologyInventors: Ishan Barman, Narahara Chari Dingari, Ramachandra Dasari, Michael Feld, Jonathan Feld, David Feld, Alison Hearn, Chae-Ryon Kong, Jeon Woong Kang
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Patent number: 9433351Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.Type: GrantFiled: May 4, 2012Date of Patent: September 6, 2016Assignee: Massachusetts Institute of TechnologyInventors: Chung-Chieh Yu, Condon Lau, Stephen Fulghum, Christopher Fang-yen, Ramachandra Dasari, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
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Publication number: 20150177133Abstract: The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.Type: ApplicationFiled: September 18, 2014Publication date: June 25, 2015Applicant: Massachusetts Institute of TechnologyInventors: Alison Hearn, David Feld, Jonathan Feld
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Publication number: 20140361148Abstract: Hilbert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron-size water droplets.Type: ApplicationFiled: June 10, 2014Publication date: December 11, 2014Inventors: Jonathan Feld, David Feld, Alison Hearn
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Publication number: 20130265585Abstract: Preferred embodiments of the present invention are directed to systems for phase measurement such as for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. Light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology.Type: ApplicationFiled: December 14, 2012Publication date: October 10, 2013Inventors: David Feld, Jonathan Feld, Alison Hearn
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Publication number: 20120307035Abstract: The present invention relates to a full-field reflection phase microscope. In a preferred embodiment, the invention can combine low-coherence interferometry and off-axis digital holographic microscopy (DHM). The reflection-based DHM provides highly sensitive and a single-shot imaging of cellular dynamics while the use of low coherence source provides a depth-selective measurement. A preferred embodiment of the system uses a diffraction grating in the reference arm to generate an interference image of uniform contrast over the entire field-of-view albeit low-coherence light source. With improved path-length sensitivity, the present invention is suitable for full-field measurement of membrane dynamics in live cells with sub-nanometer-scale sensitivity.Type: ApplicationFiled: January 25, 2012Publication date: December 6, 2012Inventors: Zahid Yaqoob, Wonshik Choi, Toyohiko Yamauchi, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
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Publication number: 20120302892Abstract: A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.Type: ApplicationFiled: December 28, 2011Publication date: November 29, 2012Inventors: Niyom Lue, Michael Feld, Ishan Barman, Narahara Chari Dingari, Ramachandra Dasari, David Feld, Alison Hearn, Jonathan Feld
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Publication number: 20120259228Abstract: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.Type: ApplicationFiled: May 4, 2012Publication date: October 11, 2012Inventors: Chung-Chieh Yu, Condon Lau, Stephen Fulghum, Christopher Fang-yen, Ramachandra Dasari, Michael Feld, David Feld, Alison Hearn, Jonathan Feld
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Publication number: 20120035442Abstract: The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.Type: ApplicationFiled: June 23, 2011Publication date: February 9, 2012Inventors: Ishan Barman, Narahara Chari Dingari, Ramachandra Dasari, Michael Feld, Chae-Ryon Kong, David Feld, Alison Hearn, Jonathan Feld
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Publication number: 20090131802Abstract: The present invention relates to an optical contact sensor for a spectroscopic probe. The sensor detects contact of the distal end of a fiber optic probe to a surface being measured. The system can be used to correct Raman spectral measurements of tissue.Type: ApplicationFiled: November 10, 2008Publication date: May 21, 2009Applicant: Newton Laboratories IncoporatedInventors: Stephen Fulghum, Charles Von Rosenberg, Jonathan Feld, Sudha Thimaraju
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Publication number: 20070038124Abstract: The present invention relates to systems and methods used in the measurement of arterial tissue. Optical probes in accordance with the invention use optical fibers to deliver and collect light using a sidelooking catheter. Diffused white light and fluorescence scattering is collected and processed to provide for improved artery wall diagnosis.Type: ApplicationFiled: June 2, 2006Publication date: February 15, 2007Inventors: Stephen Fulghum, Sudha Thimmaraju, Jonathan Feld