Abstract: The present disclosure relates to extracellular vesicles comprising one or more antigens from a coronavirus (e.g., SARS-CoV-1 or SARS-CoV-2) and optionally an adjuvant. Also provided herein are methods for producing the EVs and methods for using the EVs to treat and/or prevent diseases or disorders, e.g., infectious diseases.

Abstract: The present disclosure provides methods of producing extracellular vesicles and methods of increasing extracellular vesicle production from producer cells, which exhibit a reduced gene and/or protein function in a cholesterol biosynthetic pathway. Also provided are cell compositions having a reduced gene and/or protein function in a cholesterol biosynthetic pathway. Reducing gene and/or protein function in a cholesterol biosynthetic pathway increases the yield and production of extracellular vesicles from the producer cells.

Abstract: The present disclosure relates extracellular vesicles, e.g., exosomes, comprising an antigen-binding moeity, e.g., a single-domain antigen-binding moeity, e.g., a vNAR, a VHH, or a fragment thereof, that specifically binds transferrin receptor, and methods of making and using the same.

Abstract: The present disclosure relates to extracellular vesicles (EVs) that are capable of targeting a cell in the CNS of a subject. Also provided herein are methods for producing the EVs and methods for using the EVs to treat and/or prevent diseases or disorders of the CNS (e.g., neurological disorders).

Abstract: The present disclosure relates to extracellular vesicles, e.g., exosomes, comprising an AAV and a scaffold protein. In some aspects, the AAV is in the lumen of the extracellular vesicle. In some aspects, the AAV is associated with the luminal surface of the extracellular vesicle. In some aspects, the AAV is associated with the exterior surface of the extracellular vesicle. Also provided herein are methods for producing the exosomes and methods for using the exosomes to treat and/or prevent diseases or disorders.

Abstract: Systems and methods for identifying musical sounds are provided. In one implementation, a method includes receiving a collection of sound identifiers. Each sound identifier in the collection identifies a sound. Each sound identifier is associated with a corresponding audio representation. The collection of sound identifiers is used to construct a hierarchy of sound identifiers where each sound identifier appears only once in the hierarchy of sound identifiers. The hierarchy of sound identifiers is arranged according to a musical similarity between the sounds identified by the collection of sound identifiers. A selection of a first sound identifier is received. The first audio representation corresponding to the first sound identified by the first sound identifier is unavailable. The second sound identifier identifies a second sound that is musically similar to the first sound identified by the first sound identifier.

Abstract: Systems and methods for identifying musical sounds are provided. In one implementation, a method includes receiving a collection of sound identifiers. Each sound identifier in the collection identifies a sound. Each sound identifier is associated with a corresponding audio representation. The collection of sound identifiers is used to construct a hierarchy of sound identifiers where each sound identifier appears only once in the hierarchy of sound identifiers. The hierarchy of sound identifiers is arranged according to a musical similarity between the sounds identified by the collection of sound identifiers. A selection of a first sound identifier is received. The first audio representation corresponding to the first sound identified by the first sound identifier is unavailable. The second sound identifier identifies a second sound that is musically similar to the first sound identified by the first sound identifier.

Abstract: Systems and methods for using musical data are provided. In one implementation, a method is provided that includes receiving input selecting a musical phrase including musical data. A copy of the musical phrase is created and persistently stored. An input is received selecting a destination location in a musical score. The copy of the persistently stored musical phrase is placed into the musical score at the selected location.