Patents by Inventor Jonathan Fletcher

Jonathan Fletcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of gastrointestinal stromal tumors
    Publication number: 20040023976
    Abstract: 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of the formula (I) or a pharmaceutically acceptable salt thereof can be used in the treatment of gastrointestinal stromal tumours.
    Type: Application
    Filed: August 11, 2003
    Publication date: February 5, 2004
    Inventors: Elisabeth Buchdunger, Renaud Capdeville, George Daniel Demetri, Sasa Dimitrijevic, Brian Jay Druker, Jonathan A. Fletcher, Michael C. Heinrich, Heikki Joensuu, Sandra Leta Silberman, David Tuveson
  • Colorimetric in situ hybridization detection methods
    Publication number: 20030044822
    Abstract: The invention is a method for genomic subtractive hybridization. Specific nucleic acid sequences are removed from a sample of nucleic acid sequences by specifically hybridizing the sequences to a complementary nucleic acid sequence bound to a target molecule such as biotin. The target molecule is then contacted with a binding partner such as avidin and separated from the sample of nucleic acid sequences. As the target is separated from the sample the hybridized nucleic acid sequences are also removed from the sample. The method preferably involves the removal of repetitive nucleic acid sequences from a nucleic acid sample to generate a library of probes that are substantially free of repetitive nucleic acid sequences.
    Type: Application
    Filed: April 26, 2002
    Publication date: March 6, 2003
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Jonathan Fletcher, Sheng Xiao
  • PAX8-PPARgamma nucleic acid molecules and polypeptides and uses thereof
    Publication number: 20020106796
    Abstract: An oncogene designated PAX8-PPAR&ggr;1 contains a PAX8 coding region fused to PPAR&ggr; coding region. Molecular characterization of PAX8-PPAR&ggr;1 molecules provides nucleotide and amino acid sequences useful for detection and treatment of certain tumors, particularly thyroid follicular carcinomas.
    Type: Application
    Filed: January 18, 2001
    Publication date: August 8, 2002
    Inventors: Jonathan A. Fletcher, Todd G. Kroll
  • HMGI(Y)-LAMA4* fusion oncogene, oncoprotein and methods of use
    Patent number: 6150110
    Abstract: An oncogene designated HMGI(Y)-LAMA4* incorporates a HMGI(Y) domain fused through inversion and translocation to LAMA4*, a novel gene transcript with a epidermal-growth-factor-like/zinc-finger-like motif. Molecular characterization of HMGI(Y)-LAMA4* provides nucleic acid sequences and amino acid sequences useful for detection and treatment of certain tumors.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: November 21, 2000
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Jonathan Fletcher, Sheng Xiao