Abstract: The present disclosure is directed to improved virus-like particle (VLP) compositions and vaccines for use in inducing an immune response and/or protective immunity against a Chikungunya virus (CHIKV) infection in a subject, e.g., by inducing a neutralizing antibody response against CHIKV in a subject within 7 days after administration of a single dose of the composition or vaccine.

Abstract: A size M×N sparse matrix, including zero values, is multiplied with a size N vector, using a processor arrangement. A data storage linked to the processor arrangement stores the matrix in a compressed formal. Zero values are not stored. The data storage stores the vector as vector parts, each of a respective size Ki, 1<Ki<N and i=1 . . . P. A vector part comprises a vector element in common with another vector part. Each vector part is stored in a distinct memory block. Each of a plurality of the non-zero values of a matrix row is associated with a memory block storing an element of the vector having an index corresponding with a respective index of the non-zero value. The processor arrangement multiplies, in parallel, each of the plurality of the non-zero values of the matrix row by the respective vector element having a corresponding index stored in the associated memory block.

Abstract: A size M×N sparse matrix, including zero values, is multiplied with a size N vector, using a processor arrangement. A data storage linked to the processor arrangement stores the matrix in a compressed formal. Zero values are not stored. The data storage stores the vector as vector parts, each of a respective size Ki, 1<Ki<N and i=1 . . . P. A vector part comprises a vector element in common with another vector part. Each vector part is stored in a distinct memory block. Each of a plurality of the non-zero values of a matrix row is associated with a memory block storing an element of the vector having an index corresponding with a respective index of the non-zero value. The processor arrangement multiplies, in parallel, each of the plurality of the non-zero values of the matrix row by the respective vector element having a corresponding index stored in the associated memory block.

Abstract: A method of quickly producing a vaccine for a biotype of pathogenic microorganism is described, where a nucleic acid molecule or fragment thereof is obtained from a biological sample from an animal exposed to the microorganism, a protective molecule is prepared based on the nucleic acid molecule of interest or fragment thereof, and administered to an animal which has been or is as risk of being exposed to the microorganism. A protective response to the biotype of the microorganism is obtained in the animal.