Abstract: Methods for determining a variant frequency in a test sample from a subject, and methods for labeling sequencing reads as having or not having a variant are described herein. Exemplary methods include generating a reference match score and a variant match score by aligning sequencing reads to a corresponding variant sequence and a corresponding reference sequence, and labeling the sequencing read as having or not having the variant based on the determined match scores. Also described herein are methods monitoring disease progression and methods of treating a subject having a disease. Further described are devices and systems for implementing such methods.

Abstract: A “reduced button count” remote control device controls a set of external electronic devices that, collectively, comprise an entertainment system such as a home theater. The remote control device is operable in conjunction with a processor-based subsystem that is programmable to respond to a spoken command phrase for selectively altering an operational state of one or more of the external electronic devices to cause the entertainment system to enter a given activity. The remote control device includes a set of buttons supported within a housing, the set of buttons consisting essentially of a push-to-talk button, a first subset of buttons dedicated to providing up and down volume and channel control, a second subset of buttons dedicated to providing motion control, and a third subset buttons dedicated to providing menu selection control. Preferably, each of the buttons has a fixed, given function irrespective of the particular command phrases or the given system activities.

Abstract: A “reduced button count” remote control device controls a set of external electronic devices that, collectively, comprise an entertainment system such as a home theater. The remote control device is operable in conjunction with a processor-based subsystem that is programmable to respond to a spoken command phrase for selectively altering an operational state of one or more of the external electronic devices to cause the entertainment system to enter a given activity. The remote control device includes a set of buttons supported within a housing, the set of buttons consisting essentially of a push-to-talk button, a first subset of buttons dedicated to providing up and down volume and channel control, a second subset of buttons dedicated to providing motion control, and a third subset buttons dedicated to providing menu selection control. Preferably, each of the buttons has a fixed, given function irrespective of the particular command phrases or the given system activities.