Abstract: Disclosed are systems and methods including a lead anchor pushing tool with a body having an outer diameter configured to fit within an incision and abut a biological tissue of a patient, a bore at a distal end of the body having a first diameter configured to receive a lead anchor when stretched over a lead anchor delivery tube and a bore at a proximal end of the body having a second diameter, smaller than the first diameter and configured to receive the lead anchor delivery tube.

Abstract: Systems, methods, devices and computer software for delivering electrical stimulation to biological tissue are described. In some implementations, an electrical lead for implantation in a patient can include a distal portion with electrodes that are configured to generate therapeutic energy for biological tissue of the patient, such as the heart or pericardium. The distal portion can include an electrode extension having a tip electrode, the electrode extension configured to facilitate contact of the tip electrode with biological tissue of the patient when the lead is in a deployed configuration. A distal part of the lead can be configured to include a heel portion, a bend in a proximal part, and/or a bend in a distal part, to facilitate contact of an electrode located on the heel portion with biological tissue of the patient when the lead is in a deployed configuration.

Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.

Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient’s natural cerebrospinal fluid (CSF) pulsation or the patient’s heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.

Abstract: Fixation devices are disclosed herein that can be used to secure to a catheter and to tissue. The fixation devices include a body having a bore extending therethrough to receive a catheter. The fixation devices can also include suture openings or grooves to secure the devices to tissue.

Abstract: Fixation devices are disclosed herein that can be used to secure to a catheter and to tissue. The fixation devices include a body having a bore extending therethrough to receive a catheter. The fixation devices can also include suture openings or grooves to secure the devices to tissue.

Abstract: Fluid delivery systems and methods of delivering an agent and treating a disorder are disclosed that include a subcutaneously implantable port having a body defining a chamber with an open top and a delivery opening and a septum coupled to the body to extend over the open top of the chamber. The systems and methods can further include an intrathecal catheter having an proximal end configured to be coupled to the port and fluidly coupled to the delivery opening of the chamber and a plug having a body with a passage to receive the intrathecal catheter therethrough. The plug can be configured to be inserted into the fascia to protect against leakage of cerebrospinal fluid.

Abstract: Fluid delivery systems and methods of delivering an agent and treating a disorder are disclosed that include a subcutaneously implantable port having a body defining a chamber with an open top and a delivery opening and a septum coupled to the body to extend over the open top of the chamber. The systems and methods can further include an intrathecal catheter having an proximal end configured to be coupled to the port and fluidly coupled to the delivery opening of the chamber and a plug having a body with a passage to receive the intrathecal catheter therethrough. The plug can be configured to be inserted into the fascia to protect against leakage of cerebrospinal fluid.

Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.

Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.

Abstract: A method of delivering a drug to a patient using a therapy specific, pre-programmed auto-injection device includes positioning the hand-held device proximate to an infusion and aspiration location of the patient, and receiving, at a controller disposed within the housing, an infusion and aspiration profile. The infusion and aspiration profile including an infusion and aspiration protocol for controlling at least one of a plurality of syringes partially disposed within the housing. The method also includes operating at least one actuator coupled to the plurality of syringes according to the infusion and aspiration protocol, causing the syringes to expel a fluid from a respective barrel of the plurality of syringe into the infusion and aspiration location or causing the syringes to draw a fluid from the infusion and aspiration location into a respective barrel of the plurality of syringes.

Abstract: Fluid delivery systems and methods of delivering an agent and treating a disorder are disclosed that include a subcutaneously implantable port having a body defining a chamber with an open top and a delivery opening and a septum coupled to the body to extend over the open top of the chamber. The systems and methods can further include an intrathecal catheter having an proximal end configured to be coupled to the port and fluidly coupled to the delivery opening of the chamber and a plug having a body with a passage to receive the intrathecal catheter therethrough. The plug can be configured to be inserted into the fascia to protect against leakage of cerebrospinal fluid.

Abstract: Fluid delivery systems and methods of delivering a therapeutic agent are disclosed that include a subcutaneously implantable port that can be easily and efficiently located through the tissue of a patient. The port includes a body that defines a chamber having an open top, a delivery opening, and a catheter connection portion, and a septum disposed on the body, where the septum includes a lower surface extending over the open top of the chamber and an opposite, upper surface. The port further includes a cap of the port that defines an opening extending therethrough and the cap is configured to be coupled to the body to secure the septum within the port with the opening of the cap providing needle access to the septum. The cap includes a downwardly tapered surface that extends around the opening and is configured to direct a needle towards the upper surface of the septum.

Abstract: Catheters, catheter ports, connectors, and related methods are disclosed herein, e.g., for drug delivery to a subject. The catheters and catheter ports can include various features to facilitate dosing protocols that require multiple injections, and/or for reducing or eliminating damage that may occur to the catheter, port, or patient tissue as a result of multiple injections.

Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.

Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.

Abstract: A method of delivering a drug to a patient using a therapy specific, pre-programmed auto-injection device includes positioning the hand-held device proximate to an infusion and aspiration location of the patient, and receiving, at a controller disposed within the housing, an infusion and aspiration profile. The infusion and aspiration profile including an infusion and aspiration protocol for controlling at least one of a plurality of syringes partially disposed within the housing. The method also includes operating at least one actuator coupled to the plurality of syringes according to the infusion and aspiration protocol, causing the syringes to expel a fluid from a respective barrel of the plurality of syringe into the infusion and aspiration location or causing the syringes to draw a fluid from the infusion and aspiration location into a respective barrel of the plurality of syringes.

Abstract: A method for evaluating an asset for replacement includes retrieving one or more pieces of information corresponding to the asset, each piece of information corresponding to one or more factors, wherein each factor has an associated factor weight, determining, by a processing device, an associated factor score for each factor based at least in part on the pieces of information corresponding to the factor, the factor score for each factor also based at least in part on the associated factor weight, and determining a replacement eligibility score based upon the factor scores associated with two or more of the factors. In some embodiments, the method includes comparing a plurality of replacement eligibility scores corresponding to a plurality of assets and initiating creation of a schedule for the plurality of assets based on the comparison.