Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

Abstract: A system includes a drum assembly that includes a support bar having a first end and a second end, and a plurality of drum segments coupled to the support bar. The drum segments are movable between retracted and extended positions, and the drum assembly is configured to be disposed within an interior region of a coil of flexible pipe when the plurality of drum segments are in the retracted position. The system also includes a first containment flange coupled to the drum assembly at the first end, a second containment flange coupled to the drum assembly at the second end, a first coupling device configured to removably couple the first containment flange to the drum assembly, and a second coupling device configured to removably couple the second containment flange to the drum assembly. The first and second containment flanges are configured to contain the flexible pipe.

Abstract: A system includes a drum assembly that includes a support bar having a first end and a second end, and a plurality of drum segments coupled to the support bar. The drum segments are movable between retracted and extended positions, and the drum assembly is configured to be disposed within an interior region of a coil of flexible pipe when the plurality of drum segments are in the retracted position. The system also includes a first containment flange coupled to the drum assembly at the first end, a second containment flange coupled to the drum assembly at the second end, a first coupling device configured to removably couple the first containment flange to the drum assembly, and a second coupling device configured to removably couple the second containment flange to the drum assembly. The first and second containment flanges are configured to contain the flexible pipe.

Abstract: Techniques for implementing and/or operating a test head that includes an end cap assembly; a bore plug assembly including a plug fastener mechanism; an inflation fluid port and an annulus fluid port that open through the end cap assembly; and an internal inflation fluid conduit that connects the inflation fluid port to the plug fastener mechanism. The end cap assembly includes a cap end plate that covers an open end of a pipe segment, a cap sleeve to be disposed around the pipe segment, and a cap fastener mechanism that runs along an inner surface of the cap sleeve and that expands inward such that the cap fastener mechanism engages an outer surface of the pipe segment. The plug fastener mechanism is to be disposed within a pipe bore of the pipe segment and expands outward such that the plug fastener mechanism engages an inner surface of the pipe segment.

Abstract: A system includes a frame and a first pair of rollers coupled to a first side of the frame. The first pair of rollers is configured to support a first end of a pipe reel. The system also includes a first cradle disposed longitudinally between the first pair of rollers and a second pair of rollers coupled to a second side of the frame. The second pair of rollers is configured to support a second end of a pipe reel. The system also includes a second cradle disposed longitudinally between the second pair of rollers, a pipe guide coupled to a third side of the frame between the first and second sides, a pipe brake coupled to the frame, and a pipe re-spooler coupled to the frame.

Abstract: A system includes a drum assembly that includes a support bar having a first end and a second end, and a plurality of drum segments coupled to the support bar. The drum segments are movable between retracted and extended positions, and the drum assembly is configured to be disposed within an interior region of a coil of flexible pipe when the plurality of drum segments are in the retracted position. The system also includes a first containment flange coupled to the drum assembly at the first end, a second containment flange coupled to the drum assembly at the second end, a first coupling device configured to removably couple the first containment flange to the drum assembly, and a second coupling device configured to removably couple the second containment flange to the drum assembly. The first and second containment flanges are configured to contain the flexible pipe.

Abstract: Techniques for implementing and/or operating a test head that includes an end cap assembly; a bore plug assembly including a plug fastener mechanism; an inflation fluid port and an annulus fluid port that open through the end cap assembly; and an internal inflation fluid conduit that connects the inflation fluid port to the plug fastener mechanism. The end cap assembly includes a cap end plate that covers an open end of a pipe segment, a cap sleeve to be disposed around the pipe segment, and a cap fastener mechanism that runs along an inner surface of the cap sleeve and that expands inward such that the cap fastener mechanism engages an outer surface of the pipe segment. The plug fastener mechanism is to be disposed within a pipe bore of the pipe segment and expands outward such that the plug fastener mechanism engages an inner surface of the pipe segment.

Abstract: Techniques for implementing and operating a system that includes a pipe segment, which has tubing that defines a bore and a fluid conduit implemented in an annulus of the tubing, and a test head. The test head includes a shell, which defines an annulus cavity, and an inflatable bladder implemented in the annulus cavity, in which the system maintains the inflatable securing bladder in a less inflated state while pipe segment tubing is not present in the annulus cavity and increases inflation of the inflatable bladder to a more inflated state when the tubing is present in the annulus cavity to facilitate securing and sealing an open end of the pipe segment in the test head to enable integrity of the tubing to be tested at least in part by flowing a test fluid into the annulus of the tubing via a testing port on the shell.

Abstract: A system includes a drum assembly that includes a support bar having a first end and a second end, and a plurality of drum segments coupled to the support bar. The drum segments are movable between retracted and extended positions, and the drum assembly is configured to be disposed within an interior region of a coil of flexible pipe when the plurality of drum segments are in the retracted position. The system also includes a first containment flange coupled to the drum assembly at the first end, a second containment flange coupled to the drum assembly at the second end, a first coupling device configured to removably couple the first containment flange to the drum assembly, and a second coupling device configured to removably couple the second containment flange to the drum assembly. The first and second containment flanges are configured to contain the flexible pipe.

Abstract: Techniques for implementing and operating a system that includes a pipe segment, which has tubing that defines a bore and a fluid conduit implemented in an annulus of the tubing, and a test head. The test head includes a shell, which defines an annulus cavity, and an inflatable bladder implemented in the annulus cavity, in which the system maintains the inflatable securing bladder in a less inflated state while pipe segment tubing is not present in the annulus cavity and increases inflation of the inflatable bladder to a more inflated state when the tubing is present in the annulus cavity to facilitate securing and sealing an open end of the pipe segment in the test head to enable integrity of the tubing to be tested at least in part by flowing a test fluid into the annulus of the tubing via a testing port on the shell.

Abstract: Techniques for implementing and operating a system that includes a pipe segment, which has tubing that defines a bore and a fluid conduit implemented in an annulus of the tubing, and a test head. The test head includes a shell, which defines an annulus cavity, and an inflatable bladder implemented in the annulus cavity, in which the system maintains the inflatable securing bladder in a less inflated state while pipe segment tubing is not present in the annulus cavity and increases inflation of the inflatable bladder to a more inflated state when the tubing is present in the annulus cavity to facilitate securing and sealing an open end of the pipe segment in the test head to enable integrity of the tubing to be tested at least in part by flowing a test fluid into the annulus of the tubing via a testing port on the shell.

Abstract: Techniques for implementing and/or operating a pipe deployment system that includes pipe deployment equipment, which facilitates deploying a pipe segment from a pipe coil, and a pipe drum, which includes a drum body around which the pipe coil is to be disposed. The pipe drum is to be disposed on the pipe deployment equipment and the drum body includes a drum core as well as a lower paddle assembly and an upper paddle assembly, which are slidably secured to the drum core. The pipe deployment system maintains the paddle assemblies in a retracted state to enable the drum body to be inserted into the pipe coil, extends the lower paddle assembly to a more extended state to facilitate raising the drum core, and retracts the lower paddle assembly to a less extended state and extends the upper paddle assembly to the less extended state to facilitate lifting the pipe coil.

Abstract: Techniques for implementing a system including a pipe segment and a test head. The test head includes a shell that defines an annulus cavity to be used to interface with an annulus of the pipe segment, in which the shell includes a bore insert having a male taper to be inserted into a pipe bore of the pipe segment, a testing port that extends through the shell and fluidly coupled to the annulus cavity, and an internal clamp assembly including clamp segments having a female taper that slidably interface with the male taper of the bore insert, in which an outer surface diameter of the clamp segments is controlled by position of the clamp segments on the bore insert to facilitate selectively securing and sealing an open end of the pipe segment in the test head to enable integrity of the tubing to be tested.

Abstract: A system includes a drum assembly that includes a support bar having a first end and a second end, and a plurality of drum segments coupled to the support bar. The drum segments are movable between retracted and extended positions, and the drum assembly is configured to be disposed within an interior region of a coil of flexible pipe when the plurality of drum segments are in the retracted position. The system also includes a first containment flange coupled to the drum assembly at the first end, a second containment flange coupled to the drum assembly at the second end, a first coupling device configured to removably couple the first containment flange to the drum assembly, and a second coupling device configured to removably couple the second containment flange to the drum assembly. The first and second containment flanges are configured to contain the flexible pipe.

Abstract: Techniques for implementing and operating a system that includes a pipe segment, which has tubing that defines a bore and a fluid conduit implemented in an annulus of the tubing, and a test head. The test head includes a shell, which defines an annulus cavity, and an inflatable bladder implemented in the annulus cavity, in which the system maintains the inflatable securing bladder in a less inflated state while pipe segment tubing is not present in the annulus cavity and increases inflation of the inflatable bladder to a more inflated state when the tubing is present in the annulus cavity to facilitate securing and sealing an open end of the pipe segment in the test head to enable integrity of the tubing to be tested at least in part by flowing a test fluid into the annulus of the tubing via a testing port on the shell.

Abstract: Techniques for implementing a system including a pipe segment and a test head. The test head includes a shell that defines an annulus cavity to be used to interface with an annulus of the pipe segment, in which the shell includes a bore insert having a male taper to be inserted into a pipe bore of the pipe segment, a testing port that extends through the shell and fluidly coupled to the annulus cavity, and an internal clamp assembly including clamp segments having a female taper that slidably interface with the male taper of the bore insert, in which an outer surface diameter of the clamp segments is controlled by position of the clamp segments on the bore insert to facilitate selectively securing and sealing an open end of the pipe segment in the test head to enable integrity of the tubing to be tested.

Abstract: Techniques for implementing and operating a system that includes a pipe segment, which has tubing that defines a bore and a fluid conduit implemented in an annulus of the tubing, and a test head. The test head includes a shell, which defines an annulus cavity, and an inflatable bladder implemented in the annulus cavity, in which the system maintains the inflatable securing bladder in a less inflated state while pipe segment tubing is not present in the annulus cavity and increases inflation of the inflatable bladder to a more inflated state when the tubing is present in the annulus cavity to facilitate securing and sealing an open end of the pipe segment in the test head to enable integrity of the tubing to be tested at least in part by flowing a test fluid into the annulus of the tubing via a testing port on the shell.

Abstract: Techniques for implementing and operating a system that includes a pipe segment, which has tubing that defines a bore and a fluid conduit implemented in an annulus of the tubing, and a test head. The test head includes a shell, which defines an annulus cavity, and an inflatable bladder implemented in the annulus cavity, in which the system maintains the inflatable securing bladder in a less inflated state while pipe segment tubing is not present in the annulus cavity and increases inflation of the inflatable bladder to a more inflated state when the tubing is present in the annulus cavity to facilitate securing and sealing an open end of the pipe segment in the test head to enable integrity of the tubing to be tested at least in part by flowing a test fluid into the annulus of the tubing via a testing port on the shell.

Abstract: A system includes a drum assembly that includes a support bar having a first end and a second end, and a plurality of drum segments coupled to the support bar. The drum segments are movable between retracted and extended positions, and the drum assembly is configured to be disposed within an interior region of a coil of flexible pipe when the plurality of drum segments are in the retracted position. The system also includes a first containment flange coupled to the drum assembly at the first end, a second containment flange coupled to the drum assembly at the second end, a first coupling device configured to removably couple the first containment flange to the drum assembly, and a second coupling device configured to removably couple the second containment flange to the drum assembly. The first and second containment flanges are configured to contain the flexible pipe.

Abstract: A system includes a frame and a first pair of rollers coupled to a first side of the frame. The first pair of rollers is configured to support a first end of a pipe reel. The system also includes a first cradle disposed longitudinally between the first pair of rollers and a second pair of rollers coupled to a second side of the frame. The second pair of rollers is configured to support a second end of a pipe reel. The system also includes a second cradle disposed longitudinally between the second pair of rollers, a pipe guide coupled to a third side of the frame between the first and second sides, a pipe brake coupled to the frame, and a pipe re-spooler coupled to the frame.