Abstract: A personalized topical application patch includes a patch substrate having a plurality of isolated regions; and one or more active benefit agents disposed at least one of the plurality of isolated regions.

Abstract: The invention relates to mammalian cells comprising at least one prokaryotic two-component signaling (TCS) pathway comprised of an activator protein A, a response regulator (RR) protein B activated by said protein A, such activation leading to an activated RR protein B, and an output gene C operably linked to a promoter. Transcription from said promoter is activated by activated RR protein B, and the expression of output gene C defines at least a first state (0, no transcription) and a second state (1, detectable transcription). The invention further relates to logic gates designed from such cells, and methods for integrating a plurality of output signals based on the cells and logic gates of the invention.

Abstract: A new vision test, incorporating textual and non-textual elements in an image, is configured to demonstrate the effects of low cylinder astigmatism and other sources of blur on visual quality. The elements are designed to be noticeable, relevant, important and engaging. The new vision test may be utilized to supplement conventional vision testing.

Abstract: A molded contact lens comprising a stiffer optic zone relative to the peripheral zone of the contact lens provides an optical element for correcting astigmatism without the need for or substantially minimizing the need for the correction of rotational misalignment. The higher elastic modulus optic zone vaults over the cornea thereby allowing a tear lens to form. The tear lens follows or assumes the shape of the back surface of the contact lens. The combination of the tear lens and the optical zone provide an optical element for correction of refractive error.

Abstract: The invention relates to mammalian cells comprising at least one prokaryotic two-component signaling (TCS) pathway comprised of an activator protein A, a response regulator (RR) protein B activated by said protein A, such activation leading to an activated RR protein B, and an output gene C operably linked to a promoter. Transcription from said promoter is activated by activated RR protein B, and the expression of output gene C defines at least a first state (0, no transcription) and a second state (1, detectable transcription). The invention further relates to logic gates designed from such cells, and methods for integrating a plurality of output signals based on the cells and logic gates of the invention.

Abstract: A new vision test, incorporating textual and non-textual elements in an image, is configured to demonstrate the effects of low cylinder astigmatism and other sources of blur on visual quality. The elements are designed to be noticeable, relevant, important and engaging. The new vision test may be utilized to supplement conventional vision testing.

Abstract: A new vision test, incorporating textual and non-textual elements in an image, is configured to demonstrate the effects of low cylinder astigmatism and other sources of blur on visual quality. The elements are designed to be noticeable, relevant, important and engaging. The new vision test may be utilized to supplement conventional vision testing.

Abstract: A toric contact lens utilizes concentric annual rings, a continually varying lens design as a function of distance from the lens center or any other function to create a range of cylinder axis zones on a single lens.

Abstract: Soft contact lens having regions of a material forming one or more higher modulus of elasticity zones in the peripheral region of the lenses add stiffness to the contact lenses. This increased stiffness in different zones or regions enable the contact lens to be more easily handled and make it less likely to fold in on itself.

Abstract: A new vision test, incorporating textual and non-textual elements in an image, is configured to demonstrate the effects of low cylinder astigmatism and other sources of blur on visual quality. The elements are designed to be noticeable, relevant, important and engaging. The new vision test may be utilized to supplement conventional vision testing.

Abstract: Soft contact lens having regions of a material forming one or more higher modulus of elasticity zones in the peripheral region of the lenses add stiffness to the contact lenses. This increased stiffness in different zones or regions enable the contact lens to be more easily handled and make it less likely to fold in on itself.

Abstract: A molded contact lens comprising a stiffer optic zone relative to the peripheral zone of the contact lens provides an optical element for correcting astigmatism without the need for or substantially minimizing the need for the correction of rotational misalignment. The higher elastic modulus optic zone vaults over the cornea thereby allowing a tear lens to form. The tear lens follows or assumes the shape of the back surface of the contact lens. The combination of the tear lens and the optical zone provide an optical element for correction of refractive error.

Abstract: A toric contact lens utilizes concentric annual rings, a continually varying lens design as a function of distance from the lens center or any other function to create a range of cylinder axis zones on a single lens.

Abstract: Ophthalmic stabilized lenses have improved rotational properties by treating them with a wetting agent after they are at least initially polymerized.

Abstract: This document describes, among other things, systems and methods for visual representation and review of media files. A method comprises: 1) accessing a media file that includes at least an audio track; accessing a media review file, wherein the media review file is associated with the media file and further wherein the media review file includes annotation data, the annotation data including two or more users' annotation comments; 2) presenting the media file and the media review file using a graphical user interface, wherein the graphical user interface includes a vertical time bar, wherein the vertical time bar includes an indicator to indicate a position in the audio track included in the media file and further wherein annotation data displayed in the user interface vertically scrolls in synchronization with the indicator on the vertical time bar; and 3) saving any modifications to annotation data in the media review file.

Abstract: This document describes, among other things, systems and methods for visual representation and review of media files. A method comprises: 1) accessing a media file that includes at least an audio track; accessing a media review file, wherein the media review file is associated with the media file and further wherein the media review file includes annotation data, the annotation data including two or more users' annotation comments; 2) presenting the media file and the media review file using a graphical user interface, wherein the graphical user interface includes a vertical time bar, wherein the vertical time bar includes an indicator to indicate a position in the audio track included in the media file and further wherein annotation data displayed in the user interface vertically scrolls in synchronization with the indicator on the vertical time bar; and 3) saving any modifications to annotation data in the media review file.

Abstract: This document describes, among other things, systems and methods for visual representation and review of media files. A method comprises: 1) accessing a media file that includes at least an audio track; accessing a media review file, wherein the media review file is associated with the media file and further wherein the media review file includes annotation data, the annotation data including two or more users' annotation comments; 2) presenting the media file and the media review file using a graphical user interface, wherein the graphical user interface includes a vertical time bar, wherein the vertical time bar includes an indicator to indicate a position in the audio track included in the media file and further wherein annotation data displayed in the user interface vertically scrolls in synchronization with the indicator on the vertical time bar; and 3) saving any modifications to annotation data in the media review file.

Abstract: This document describes, among other things, systems and methods for streamlining communications to media stations. A method comprises an agent of a radio station group ownership entity using a website to access one or more of advertising data, scheduling data, or rewards data corresponding to at least some radio stations in the radio station group, wherein the at least some radio stations receive services from a service entity; displaying on the website to the radio station agent a simulated radio dial with an indication of which radio stations in the group of radio stations are receiving services from the service entity, and which radio stations in the group are not receiving services from the service entity; and providing on the web site to the agent an aggregate view of the advertising data, scheduling data, or rewards data for the stations receiving services from the service entity.

Abstract: A blister package having an at least partially contoured blister flange and correspondingly contoured first and second backers. The first backer includes a first flange that is coextensive with at least a portion of the blister flange. The second backer includes a second flange that is coextensive with a different portion, for example, a smaller portion or in a different location, of the blister flange than the first flange. A compartment can be defined between the first and second backers. Additional backers can be provided for additional compartments or features. The first backer can include an access panel, and the second backer can include at least one support flap that supports the blister in a stand alone position. A related method includes securing the first backer flange to the blister flange, and securing the second backer flange to the first backer flange.