Abstract: The invention provides a novel method for identifying or profiling a target cellular kinase Uses of such kinases (or their corresponding inhibitors) in diagnosis or therapy are also provided.

Abstract: An electronic billboard comprises at least one processor, at least one computer-readable tangible storage device, and program instructions stored on the at least one storage device for execution by the at least one processor. The program instructions comprise first program instructions configured to receive media content comprising text and at least one image. The program instructions further comprise second program instructions configured to separate the text and the at least one image. The program instructions further comprise third program instructions configured to cause the electronic billboard to display the text on a first predetermined portion of the electronic billboard. The program instructions further comprise fourth program instructions configured to cause the electronic billboard to display the image on a second predetermined portion of the electronic billboard.

Abstract: The present disclosure is directed to compounds of Formula (I) which are inhibitors of Haspin kinase and DYRK kinases. The compounds of the present disclosure, and compositions thereof, are useful in the treatment of disease related to Haspin kinase and DYRK kinase expression and/or activity.

Abstract: The present disclosure is directed to compounds of Formula I: which are inhibitors of Haspin kinase and DYRK kinases. The compounds of the present disclosure, and compositions thereof, are useful in the treatment of disease related to Haspin kinase and DYRK kinase expression and/or activity.

Abstract: The present invention is directed to methods for increasing or decreasing the phosphorylation of histone H3 using factors that alter the activity of the kinase haspin. The invention includes assays for identifying inhibitors, peptides that can serve as inhibitors or in the generation of antibodies that specifically recognize phosphorylated histone, polynucleotides encoding peptides, procedures for increasing intracellular haspin levels, and methods for assaying haspin activity in a biological sample to determine whether abnormalities in cell division may be due to the overexpression or underexpression of haspin.

Abstract: The present invention is directed to methods for increasing or decreasing the phosphorylation of histone H3 using factors that alter the activity of the kinase haspin. The invention includes assays for identifying inhibitors, peptides that can serve as inhibitors or in the generation of antibodies that specifically recognize phosphorylated histone, polynucleotides encoding peptides, procedures for increasing intracellular haspin levels, and methods for assaying haspin activity in a biological sample to determine whether abnormalities in cell division may be due to the overexpression or underexpression of haspin.