Abstract: A minimally invasive method of performing mitral annuloplasty is disclosed. An implantable device is positioned within the coronary sinus and tightened around the mitral annulus. Mitral valve regurgitation is monitored before, during, and/or after the tightening step. An on-going drug therapy may be determined, taking into account post-implantation hemodynamic function.

Abstract: A left ventricle restriction device is designed to be transvenously advanced and deployed within the coronary sinus and in some embodiments other coronary veins. The device places tension on adjacent structures, reducing the diameter and/or limiting diastolic expansion of the left ventricle. This may be beneficial for patients with dilated cardiomyopathy.

Abstract: This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator.

Abstract: This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator.

Abstract: A system, apparatus and method for determining prognosis in atrial fibrillation non-invasively detects electrical activity of the heart with external electrodes, such as with ECG leads. The diagnostic system, apparatus and method provide a non-invasive technique to classify the severity of atrial fibrillation according to measured values of at least one predetermined parameter of the fibrillation as observed in the frequency domain. One predetermined parameter which is measured for the purpose of classification is peak frequency. Another predetermined parameter used for atrial fibrillation classification is a change in power along the range of frequencies.

Abstract: This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator.

Abstract: A system, apparatus and method for determining prognosis in atrial fibrillation non-invasively detects electrical activity of the heart with external electrodes, such as with ECG leads. The diagnostic system, apparatus and method provide a non-invasive technique to classify the severity of atrial fibrillation according to peak frequency of the fibrillation, and provide useful information for treatment of the atrial fibrillation, including the prediction of conversion with ibutilide, and the estimation of time to recurrence after cardioversion.