Patents by Inventor Jonathan J. Liu

Jonathan J. Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
    Patent number: 11912985
    Abstract: The present disclosure provides systems, compositions, and methods for simultaneously editing both strands of a double-stranded DNA sequence at a target site to be edited. Further provided herein are pharmaceutical compositions, polynucleotides, vectors, cells, and kits for simultaneously editing both strands of a double-stranded DNA sequence.
    Type: Grant
    Filed: November 7, 2022
    Date of Patent: February 27, 2024
    Assignees: The Broad Institute, Inc., President and Fellows of Harvard College
    Inventors: David R. Liu, Andrew Vito Anzalone, Jonathan Ma Levy, Xin Gao, Christopher J. Podracky
  • Swept-source optical coherence tomography (SS-OCT) phase stabilization with reference signal calibration
    Patent number: 10627212
    Abstract: A reference signal having a known induced optical delay is used for phase stabilization of optical coherence tomography (OCT) interferograms, and for correcting sampling differences within OCT interferograms, in single mode and multimodal OCT systems. The reference signal can then be used to the measure time shift or sample clock period shifts induced in the interferogram signal by the OCT system. A corresponding OCT interferogram signal can then be corrected to remove the shift induced by the system based on the determination.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: April 21, 2020
    Assignee: KABUSHIKI KAISHA TOPCON
    Inventors: Jonathan J. Liu, Zhenguo Wang, Jongsik Kim, Kinpui Chan
  • SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY (SS-OCT) PHASE STABILIZATION WITH REFERENCE SIGNAL CALIBRATION
    Publication number: 20170307353
    Abstract: A reference signal having a known induced optical delay is used for phase stabilization of optical coherence tomography (OCT) interferograms, and for correcting sampling differences within OCT interferograms, in single mode and multimodal OCT systems. The reference signal can then be used to the measure time shift or sample clock period shifts induced in the interferogram signal by the OCT system. A corresponding OCT interferogram signal can then be corrected to remove the shift induced by the system based on the determination.
    Type: Application
    Filed: April 18, 2017
    Publication date: October 26, 2017
    Inventors: Jonathan J. Liu, Zhenguo Wang, Jongsik Kim, Kinpui Chan