Patents by Inventor Jonathan K. Watts

Jonathan K. Watts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR RESTORING STMN2 LEVELS
    Publication number: 20240011027
    Abstract: The disclosure relates to compositions and methods for treating a disease or condition associated with a TDP-pathology or a decline in TDP-43 functionality in neuronal cells in a subject, and for identifying candidate agents to suppress or prevent inclusion of an abortive or altered STMN2 RNA sequence.
    Type: Application
    Filed: March 25, 2021
    Publication date: January 11, 2024
    Inventors: Kevin C. Eggan, Joseph Robert Klim, Robert H. Brown, Jr., Jonathan K. Watts
  • TREATMENT OF FUCHS' ENDOTHELIAL CORNEAL DYSTROPHY
    Publication number: 20240002849
    Abstract: Described are compounds and methods useful in the treatment of Fuchs' Endothelial Corneal Dystrophy (FECD).
    Type: Application
    Filed: November 8, 2022
    Publication date: January 4, 2024
    Applicants: The Board of Regents of The University of Texas System, University of Massachusetts
    Inventors: Venkateswara V. MOOTHA, David R. COREY, Jiaxin HU, Jonathan K. WATTS
  • ANTI-C9ORF72 OLIGONUCLEOTIDES AND RELATED METHODS
    Publication number: 20230295629
    Abstract: The present disclosure provides antisense compounds, methods, and compositions for silencing C9ORF72 transcripts. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with C9ORF72 in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with C9ORF72.
    Type: Application
    Filed: March 3, 2023
    Publication date: September 21, 2023
    Inventors: Robert H. Brown, Jr., Jonathan K. Watts, Helene Tran, Michael Moazami
  • Anti-C9ORF72 oligonucleotides and related methods
    Patent number: 11629347
    Abstract: The present disclosure provides antisense compounds, methods, and compositions for silencing C9ORF72 transcripts. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with C9ORF72 in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with C9ORF72.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: April 18, 2023
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Robert H. Brown, Jr., Jonathan K. Watts, Helene Tran, Michael Moazami
  • ANTI-SLC6A1 OLIGONUCLEOTIDES AND RELATED METHODS
    Publication number: 20230041016
    Abstract: The present disclosure provides antisense oligonucleotides that bind to a splice modulatory element target region in an SLC6A1 RNA transcript. The present disclosure provides antisense oligonucleotides that increase the expression of a functional protein encoded by the SLC6A1 RNA transcript in a cell (i.e., GABA Transporter 1, GAT-1). The present disclosure also provides methods of treating a disease or disorder associated with non-productive SLC6A1 RNA transcripts.
    Type: Application
    Filed: December 4, 2020
    Publication date: February 9, 2023
    Inventors: Athma A. PAI, Jonathan K. WATTS, Kaitlyn VALLA, Eraj Shafiq KHOKHAR
  • IDENTIFYING NON-PRODUCTIVE SPLICE SITES
    Publication number: 20230022489
    Abstract: The present disclosure provides methods of identifying non-productive splice sites in target RNA transcripts and antisense oligonucleotides that increase the expression of said target RNA transcripts. In an embodiment, the target RNA transcript comprises ADAR, ARSA, ATPIA2, CACNAIA, DNMI, EIF2BI, EIF2B2, EIF2B5, IDUA, MFSD8, NF2, NPC1L PEXI, PRICKLE2, PRRT2, RAM, SETD5, SHANKS, SLC6A1, STXBPI, STX1B, and TCF4.
    Type: Application
    Filed: December 4, 2020
    Publication date: January 26, 2023
    Inventors: Athma A. PAI, Jonathan K. WATTS, Kaitlyn VALLA, Eraj Shafiq KHOKHAR, Zachary KARTJE
  • TREATMENT OF FUCHS' ENDOTHELIAL CORNEAL DYSTROPHY
    Publication number: 20210139894
    Abstract: Described are compounds and methods useful in the treatment of Fuchs' Endothelial Corneal Dystrophy (FECD).
    Type: Application
    Filed: March 9, 2018
    Publication date: May 13, 2021
    Applicants: The Board of Regents of the University of Texas System, University of Massachusetts
    Inventors: Venkateswara V. MOOTHA, David R. COREY, Jiaxin HU, Jonathan K. WATTS
  • ANTI-C9ORF72 OLIGONUCLEOTIDES AND RELATED METHODS
    Publication number: 20200385723
    Abstract: The present disclosure provides antisense compounds, methods, and compositions for silencing C9ORF72 transcripts. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with C9ORF72 in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with C9ORF72.
    Type: Application
    Filed: May 6, 2020
    Publication date: December 10, 2020
    Inventors: Robert H. Brown, JR., Jonathan K. Watts, Helene Tran, Michael Moazami
  • Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof
    Patent number: 9719091
    Abstract: Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2?-substituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2?-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: August 1, 2017
    Assignee: Paladin Labs, Inc.
    Inventors: Masad J. Damha, Jonathan K. Watts, Glen Deleavey
  • OLIGONUCLEOTIDE DUPLEXES COMPRISING DNA-LIKE AND RNA-LIKE NUCLEOTIDES AND USES THEREOF
    Publication number: 20160145613
    Abstract: Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2?-substituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2?-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed.
    Type: Application
    Filed: July 27, 2015
    Publication date: May 26, 2016
    Inventors: Masad J. Damha, Jonathan K. Watts, Glen Deleavey
  • Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof
    Patent number: 9090649
    Abstract: Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2?-sub-stituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2?-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: July 28, 2015
    Assignee: Paladin Labs, Inc.
    Inventors: Masad J. Damha, Jonathan K. Watts, Glen Deleavey
  • OLIGONUCLEOTIDE DUPLEXES COMPRISING DNA-LIKE AND RNA-LIKE NUCLEOTIDES AND USES THEREOF
    Publication number: 20110077286
    Abstract: Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2?-substituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2?-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed.
    Type: Application
    Filed: June 5, 2009
    Publication date: March 31, 2011
    Inventors: Masad J. Damha, Jonathan K. Watts, Glen Deleavey
  • 4'-THIOARABINONUCLEOTIDE-CONTAINING OLIGONUCLEOTIDES, COMPOUNDS AND METHODS FOR THEIR PREPARATION AND USES THEREOF
    Publication number: 20090069263
    Abstract: Oligonucleotides comprising one or more 4?-thioarabinonucleotides are described, as well as uses thereof for applications such as antisense- and RNAi-based gene silencing. 4?-thioarabinose-based phosphoramidite and H-phosphonate compounds are also described, as well as uses thereof for the synthesis of oligonucleotides comprising one or more 4?-thioarabinonucleotides.
    Type: Application
    Filed: December 14, 2006
    Publication date: March 12, 2009
    Inventors: Masad J. Damha, Jonathan K. Watts, B. Mario Pinto