Patents by Inventor Jonathan Kenneth Watts

Jonathan Kenneth Watts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITING
    Publication number: 20240309396
    Abstract: The disclosure provides methods and compositions for gene editing. In particular. the disclosure relates to compositions and methods of making and using modified nucleic acid donor templates for highly efficient and precise gene editing, such as gen editing in immune cells.
    Type: Application
    Filed: January 26, 2024
    Publication date: September 19, 2024
    Inventors: Jonathan Kenneth Watts, Erik Joseph Sontheimer, Craig Cameron Mello, Zexiang Chen, Krishna Sumanth Ghanta
  • Compositions and methods for improved gene editing
    Patent number: 11981892
    Abstract: The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: May 14, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Craig Cameron Mello, Krishna Sumanth Ghanta, Gregoriy Dokshin, Aamir Mir, Hassan Gneid, Jonathan Kenneth Watts, Erik Joseph Sontheimer
  • COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITING
    Publication number: 20240124870
    Abstract: The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.
    Type: Application
    Filed: June 9, 2023
    Publication date: April 18, 2024
    Inventors: Craig Cameron Mello, Krishna Sumanth Ghanta, Gregoriy Dokshin, Aamir Mir, Hassan Gneid, Jonathan Kenneth Watts, Erik Joseph Sontheimer
  • PROTECTING OLIGONUCLEOTIDES FOR CRISPR GUIDE RNA
    Publication number: 20230407295
    Abstract: Protecting oligonucleotides are provided. Protecting oligonucleotides with 5? and/or 3? conjugated moieties are provided. Protecting oligonucleotides with chemical modifications are provided. Methods of using the protecting oligonucleotides for genome editing with a CRISPR nuclease and kits for performing the same are also provided.
    Type: Application
    Filed: April 28, 2023
    Publication date: December 21, 2023
    Inventors: Han Zhang, Erik Joseph Sontheimer, Jonathan Kenneth Watts, Anastasia Khvorova
  • MODIFIED GUIDE RNAS FOR NEISSERIA MENINGITIDIS CAS9
    Publication number: 20230183687
    Abstract: Chemically modified Neisseria meningitidis (Nme) crRNAs, tracrRNAs, and sgRNAs are provided. Methods of using the Nme crRNAs, tracrRNAs, and sgRNAs for genome editing with a Nme CRISPR nuclease and kits for performing the same are also provided.
    Type: Application
    Filed: October 12, 2022
    Publication date: June 15, 2023
    Inventors: Erik Joseph Sontheimer, Jonathan Kenneth Watts, Anastasia Khvorova, Nathan Bamidele
  • MODIFIED GUIDE RNAS FOR CRISPR GENOME EDITING
    Publication number: 20210388348
    Abstract: Chemically modified crRNAs and tracrRNAs are provided. crRNAs and tracrRNAs with 5? and/or 3? conjugated moieties are provided. crRNAs and tracrRNAs with modifications in the repeat region of the crRNA or the anti-repeat region of the tracrRNA are provided. Methods of using the crRNAs and tracrRNAs for genome editing with a CRISPR nuclease and kits for performing the same are also provided.
    Type: Application
    Filed: May 12, 2021
    Publication date: December 16, 2021
    Inventors: Erik Joseph Sontheimer, Anastasia Khvorova, Jonathan Kenneth Watts, Nadia Amrani, Zexiang Chen, Matthew Hassler, Dimas Echeverria Moreno, Julia Frances Alterman, Scot Wolfe, Ken Yamada, Gitali Devi, Han Zhang
  • MODIFIED GUIDE RNAS FOR CRISPR GENOME EDITING
    Publication number: 20210363518
    Abstract: Chemically modified crRNAs and tracrRNAs are provided. crRNAs and tracrRNAs with 5? and/or 3? conjugated moieties are provided. crRNAs and tracrRNAs with modifications in the repeat region of the crRNA or the anti-repeat region of the tracrRNA are provided. Methods of using the crRNAs and tracrRNAs for genome editing with a CRISPR nuclease and kits for performing the same are also provided.
    Type: Application
    Filed: March 18, 2019
    Publication date: November 25, 2021
    Inventors: Erik Joseph SONTHEIMER, Anastasia KHVOROVA, Jonathan Kenneth WATTS, Aamir MIR, Julia Frances ALTERMAN, Matthew Ryan HASSLER, Michael Harry BRODSKY, Alexandre Jean-Marie DEBACKER
  • COMPOSITIONS AND METHODS FOR IMPROVED GENE EDITING
    Publication number: 20190345479
    Abstract: The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.
    Type: Application
    Filed: April 15, 2019
    Publication date: November 14, 2019
    Inventors: Craig Cameron Mello, Krishna Sumanth Ghanta, Gregoriy Dokshin, Aamir Mir, Hassan Gneid, Jonathan Kenneth Watts, Erik Joseph Sontheimer