Patents by Inventor Jonathan Kirk

Jonathan Kirk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BAG3 METHODS AND USES FOR TREATMENT OF INFLAMMATION
    Publication number: 20260000789
    Abstract: Bag3 is a multifunctional protein expressed predominantly in the heart, the skeletal muscle, the central nervous system and in many cancers. Although BAG3 was cloned only a decade ago, studies have shown that genetic variants, particularly those that result in haplo-insufficiency, can lead to severe left ventricular dysfunction; however, the full mechanisms responsible have remained obscure. To obviate the influence of heart failure itself on the biology of Bag3, transgenic mice harboring a single allele knock-out were studied between 8 and 10 weeks of age before any obvious signs of heart failure were evident. The results were surprising and informative. First, it was found that despite a normal phenotype, young Bag3+/? had marked changes in the proteome that were characterized by changes in proteins associated with metabolism and apoptosis. Consistent with this finding, a decrease in the levels of critical proteins charged with maintaining the mitochondrial membrane potential was observed.
    Type: Application
    Filed: October 21, 2022
    Publication date: January 1, 2026
    Applicants: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, LOYOLA UNIVERSITY OF CHICAGO
    Inventors: Arthur M. FELDMAN, Jonathan KIRK
  • METHODS FOR IMPROVING HEART FUNCTION
    Publication number: 20230293891
    Abstract: The invention provides methods related to improving heart function.
    Type: Application
    Filed: November 22, 2022
    Publication date: September 21, 2023
    Inventors: David KASS, Gordon TOMASELLI, Jonathan KIRK
  • BAG3 METHODS AND USES FOR TREATMENT OF INFLAMMATION
    Publication number: 20230241162
    Abstract: Bag3 is a multifunctional protein expressed predominantly in the heart, the skeletal muscle, the central nervous system and in many cancers. Although BAG3 was cloned only a decade ago, studies have shown that genetic variants, particularly those that result in haplo-insufficiency, can lead to severe left ventricular dysfunction; however, the full mechanisms responsible have remained obscure. To obviate the influence of heart failure itself on the biology of Bag3, ransgenic mice harboring a single allele knock-out were studied between 8 and 10 weeks of age before any obvious signs of heart failure were evident. The results were surprising and informative. First, it was found that despite a normal phenotype, young Bag3+/? had marked changes in the proteome that were characterized by changes in proteins associated with metabolism and apoptosis. Consistent with this finding, a decrease in the levels of critical proteins charged with maintaining the mitochondrial membrane potential was observed.
    Type: Application
    Filed: October 21, 2022
    Publication date: August 3, 2023
    Inventors: Arthur M. FELDMAN, Jonathan KIRK
  • Methods for improving heart function
    Patent number: 11633606
    Abstract: The invention provides methods related to improving heart function.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: April 25, 2023
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: David Kass, Gordon Tomaselli, Jonathan Kirk
  • METHODS FOR IMPROVING HEART FUNCTION
    Publication number: 20200147381
    Abstract: The invention provides methods related to improving heart function.
    Type: Application
    Filed: November 19, 2019
    Publication date: May 14, 2020
    Inventors: David KASS, Gordon TOMASELLI, Jonathan KIRK
  • Methods for improving heart function
    Patent number: 10525269
    Abstract: The invention provides methods related to improving heart function.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: January 7, 2020
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: David Kass, Gordon Tomaselli, Jonathan Kirk
  • METHODS FOR IMPROVING HEART FUNCTION
    Publication number: 20170182321
    Abstract: The invention provides methods related to improving heart function.
    Type: Application
    Filed: November 22, 2016
    Publication date: June 29, 2017
    Inventors: David KASS, Gordon TOMASELLI, Jonathan KIRK
  • Methods for improving heart function
    Patent number: 9539427
    Abstract: The invention provides methods related to improving heart function.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: January 10, 2017
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: David Kass, Gordon Tomaselli, Jonathan Kirk
  • METHODS FOR IMPROVING HEART FUNCTION
    Publication number: 20130304149
    Abstract: The invention provides methods related to improving heart function.
    Type: Application
    Filed: November 8, 2011
    Publication date: November 14, 2013
    Inventors: David Kass, Gordon Tomaselli, Jonathan Kirk