Abstract: A system, apparatus, and method to identify incentives in multi-party interactions where such incentives are represented by specification value pairs and through the use of game theory, machine leaning, pattern identification and recognition and/or digital twins in any arrangement, misalignment of such specification value pairs may be identified and responded to in manner that can avoid and/or mitigate the impact of such misalignments on the interactions of those parties, including in pursuit of the reduction of fraud or other undesirable behaviors within at least one system.

Abstract: A system, apparatus, and method to identify incentives in multi-party interactions where such incentives are represented by specification value pairs and through the use of game theory, machine leaning, pattern identification and recognition and/or digital twins in any arrangement, misalignment of such specification value pairs may be identified and responded to in manner that can avoid and/or mitigate the impact of such misalignments on the interactions of those parties, including in pursuit of the reduction of fraud or other undesirable behaviors within at least one system.

Abstract: A system, apparatus, and method to identify incentives in multi-party interactions where such incentives are represented by specification value pairs and through the use of game theory, machine leaning, pattern identification and recognition and/or digital twins in any arrangement, misalignment of such specification value pairs may be identified and responded to in manner that can avoid and/or mitigate the impact of such misalignments on the interactions of those parties, including in pursuit of the reduction of fraud or other undesirable behaviors within at least one system.

Abstract: The disclosed implementations can provide a state-based history based on capture, representation, and navigation of a user's exploratory interactions with a user interface of an application. States may be represented in a history board, and one or more states may form a path. As a user explores an application's user interface, the user may branch from a given path and/or return to a prior state. Displaying a visual indication of states and a relationship of those states within a given path to states in other paths, provides a much improved user experience.

Abstract: The present disclosure provides compositions and methods for modulating PERK activity and/or expression in cells for use in treatment or prevention of viral infection, including by reducing translation of viral non-structural proteins in cells using compositions and/or compounds that inhibit PERK activity and/or expression.

Abstract: A system for determining the occurrence of an event and for issuing notifications responsive the occurrence of the event. The system has a first component for storing reference parameters for use in determining occurrence of the event and a sensor for determining real-time parameters that may be indicative of the occurrence of the event. An analysis component analyzes the real-time parameters relative to the reference parameters. If the event is detected a communications component issues a notification to those effected by the event.

Abstract: The disclosed implementations can provide a state-based history based on capture, representation, and navigation of a user's exploratory interactions with a user interface of an application. States may be represented in a history board, and one or more states may form a path. As a user explores an application's user interface, the user may branch from a given path and/or return to a prior state. Displaying a visual indication of states and a relationship of those states within a given path to states in other paths, provides a much improved user experience.

Abstract: A system for determining the occurrence of an event and for issuing notifications responsive the occurrence of the event. The system has a first component for storing reference parameters for use in determining occurrence of the event and a sensor for determining real-time parameters that may be indicative of the occurrence of the event. An analysis component analyzes the real-time parameters relative to the reference parameters. If the event is detected a communications component issues a notification to those effected by the event.

Abstract: A system for determining occurrence of an event and for issuing notifications responsive thereto. The system comprises a first component for storing reference parameters for use in determining occurrence of the event and a a sensor for determining real-time parameters that would be indicative of the occurrence of the event. An analysis component for compares the reference parameters and the real-time parameters. A communications component issues a notification responsive to detection of the event and an event-driven event management network is established responsive to the notification.

Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.

Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.

Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.

Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.

Abstract: The invention relates to methods and systems for detecting and or analyzing an agent in a sample with a chip having optical components incorporated therein.

Abstract: Microfludic channels are constructed for use in preparing and/or analyzing samples. In one embodiment, a microchannel delivers multiple fluid samples from an upstream portion to a downstream portion of the channel where each of the fluid samples are separated from one another by a sheathing fluid that also travels toward the downstream portion. In another embodiment, a microchannel is constructed to create multiple elongational flows in series that can align polymers from a coiled state.

Abstract: Microfludic channels are constructed for use in preparing and/or analyzing samples. In one embodiment, a microfluidic channel receives a carrier fluid having both non-targets and targets. The non-targets are moved from the carrier fluid by diffusion and into sheathing fluids also present in the channel before contents of the carrier fluid are analyzed.

Abstract: The invention relates to methods and systems for detecting and or analyzing an agent in a sample with a chip having optical components incorporated therein.

Abstract: The invention relates to the methods for analyzing polymers that are in unstretched conformations. In particular, the polymers such as nucleic acids may be present in hairpin conformations.

Abstract: An apparatus and method incorporating at least two sensors that detect the presence of substrate defects, such as breakage or misalignment, along the lengths of at least two parallel edges of a moving substrate. In one embodiment, an apparatus for detecting substrate defects includes a sensor arrangement including at least two sensors that continuously sense a substrate near at least two parallel edges of the substrate as the substrate passes the sensors. In another embodiment, an apparatus for detecting substrate defects includes a robot having a substrate support surface, and a sensor arrangement including at least two sensors that continuously sense a substrate near at least two parallel edges of the substrate during substrate transfer on the substrate support surface.

Abstract: A microfluidic device for altering the flow of a carrier fluid containing a polymer, such that, the polymer can be positioned, aligned, or elongated. The device accomplishes these effects by directing the carrier fluid in a laminar flow into obstacles, or other fluids to knowingly alter the path of the carrier fluid streamlines. These streamlines, in turn, apply fluidic drag forces against the polymer to manipulate it into a desired configuration. Other aspects of the device retain a polymer in an aligned or elongated state with crimps which prevent portions of the polymer from coiling. These structures utilize the natural concept of increasing entropy to allow small portions of an aligned or elongated polymer to return to a high entropy, or coiled state, while retaining the majority of the polymer in a low entropy, aligned or elongated state for subsequent analysis or manipulation.