Patents by Inventor Jonathan LeBowitz

Jonathan LeBowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acid alpha-glucosidase and fragments thereof
    Publication number: 20080299640
    Abstract: Targeted acid alpha-glucosidase therapeutics that localize to the lysosome are provided. The targeted therapeutics include a therapeutic agent, GAA, and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.
    Type: Application
    Filed: September 12, 2007
    Publication date: December 4, 2008
    Applicant: ZyStor Therapeutics, Inc.
    Inventors: Jonathan LeBowitz, John Maga
  • Methods and Compositions for Targeting Proteins Across the Blood Brain Barrier
    Publication number: 20080241118
    Abstract: Disclosed are methods and compositions for targeting therapeutic proteins to the brain. Methods and compositions of the invention involve associating an IGF moiety with a therapeutic protein in order to target the therapeutic protein to the brain. Soluble fusion proteins that include an IGF targeting moiety are transported to neural tissue in the brain from blood. Methods and compositions of the invention include therapeutic applications for treating lysosomal storage diseases. The invention also provides nucleic acids and cells for expressing IGF fusion proteins.
    Type: Application
    Filed: February 19, 2008
    Publication date: October 2, 2008
    Applicant: ZyStor Therapeutics, Inc.
    Inventor: Jonathan LeBowitz
  • Methods and compositions for targeting proteins across the blood brain barrier
    Publication number: 20060121018
    Abstract: Disclosed are methods and compositions for targeting therapeutic proteins to the brain. Methods and compositions of the invention involve associating an IGF moiety with a therapeutic protein in order to target the therapeutic protein to the brain. Soluble fusion proteins that include an IGF targeting moiety are transported to neural tissue in the brain from blood. Methods and compositions of the invention include therapeutic applications for treating lysosomal storage diseases. The invention also provides nucleic acids and cells for expressing IGF fusion proteins.
    Type: Application
    Filed: September 23, 2005
    Publication date: June 8, 2006
    Applicant: ZyStor Therapeutics, Inc.
    Inventor: Jonathan LeBowitz
  • Nuclear factors associated with transcriptional regulation
    Publication number: 20060063709
    Abstract: Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription can be isolated and employed to enhance transcription of Ig genes. In particular, NF-kB, the gene encoding NF-kB, IkB and the gene encoding IkB and uses therefor.
    Type: Application
    Filed: January 4, 2002
    Publication date: March 23, 2006
    Inventors: David Baltimore, Ranjan Sen, Phillip Sharp, Harinder Singh, Louis Staudt, Jonathan LeBowitz, Albert Baldwin, Roger Clerc, Lynn Corcoran, Patrick Baeuerle, Michael Lenardo, Chen-Ming Fan, Thomas Maniatis
  • Targeted therapeutic proteins
    Publication number: 20050281805
    Abstract: Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.
    Type: Application
    Filed: November 3, 2004
    Publication date: December 22, 2005
    Applicant: Symbiontics, Inc.
    Inventors: Jonathan LeBowitz, Stephen Beverley, William Sly
  • Acid alpha-glucosidase and fragments thereof
    Publication number: 20050244400
    Abstract: Targeted acid alpha-glucosidase therapeutics that localize to the lysosome are provided. The targeted therapeutics include a therapeutic agent, GAA, and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.
    Type: Application
    Filed: February 10, 2005
    Publication date: November 3, 2005
    Applicant: ZyStor Therapeutics, Inc.
    Inventors: Jonathan LeBowitz, John Maga
  • Methods and compositions for targeting proteins across the blood brain barrier
    Publication number: 20030072761
    Abstract: Disclosed are methods and compositions for targeting therapeutic proteins to the brain. Methods and compositions of the invention involve associating an IGF moiety with a therapeutic protein in order to target the therapeutic protein to the brain. Soluble fusion proteins that include an IGF targeting moiety are transported to neural tissue in the brain from blood. Methods and compositions of the invention include therapeutic applications for treating lysosomal storage diseases. The invention also provides nucleic acids and cells for expressing IGF fusion proteins.
    Type: Application
    Filed: April 30, 2002
    Publication date: April 17, 2003
    Inventor: Jonathan LeBowitz