Patents by Inventor Jonathan Lee Coffman

Jonathan Lee Coffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tandem purification of proteins
    Patent number: 9428546
    Abstract: The present disclosure provides methods for purifying products from a fluid. In some embodiments, provided purification methods use a combination of purification modes (e.g., protein A and ion exchange) operated in tandem, wherein at least one of the modes utilizes weak partitioning. In some embodiments, provided purification methods operate under robust conditions in which a degree of binding between a product and resin is maintained despite variations in operating parameters.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: August 30, 2016
    Assignee: Pfizer Inc.
    Inventors: Jonathan Lee Coffman, Ranganathan Godavarti, Michael Shamashkin
  • Method of weak partitioning chromatography
    Patent number: 9144755
    Abstract: This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid containing one or more impurities. Further, the invention relates to methods of weak partitioning chromatography defined by operating conditions which cause a medium to bind least 1 mg of product per mL of medium, or alternatively, defined by a partition coefficient of at least 0.1.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: September 29, 2015
    Assignee: Wyeth LLC
    Inventors: Paul R. Brown, Jonathan Lee Coffman, Ranganathan Godavarti, Timothy Iskra, Brian D. Kelley, Suresh Vunnum, Shujun Sun, Tianning Yu, James Edward Booth, Mary Beth Switzer
  • Tandem Purification of Proteins
    Publication number: 20130317198
    Abstract: The present disclosure provides methods for purifying products from a fluid. In some embodiments, provided purification methods use a combination of purification modes (e.g., protein A and ion exchange) operated in tandem, wherein at least one of the modes utilizes weak partitioning. In some embodiments, provided purification methods operate under robust conditions in which a degree of binding between a product and resin is maintained despite variations in operating parameters.
    Type: Application
    Filed: July 29, 2011
    Publication date: November 28, 2013
    Applicant: Pfizer Inc.
    Inventors: Jonathan Lee Coffman, Ranganathan Godavarti, Michael Shamashkin