Patents by Inventor Jonathan Lee Tilly

Jonathan Lee Tilly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for Producing Germ Cells from Bone Marrow Derived Germline Stem Cells
    Publication number: 20190352602
    Abstract: The present invention provides bone marrow derived germline stem cells and their progenitors, methods of isolation thereof, and methods of use thereof.
    Type: Application
    Filed: January 22, 2019
    Publication date: November 21, 2019
    Inventors: Jonathan Lee Tilly, Joshua Johnson
  • Compositions and Methods for Autologous Germline Mitochondrial Energy Transfer
    Publication number: 20190300850
    Abstract: Oogonial stem cell (OSC)-derived compositions, such as nuclear free cytoplasm or isolated mitochondria, and uses of OSC-derived compositions in autologous fertility-enhancing procedures are described.
    Type: Application
    Filed: December 21, 2018
    Publication date: October 3, 2019
    Inventors: Jonathan Lee Tilly, Dori C. Woods
  • Sequencing Methods
    Publication number: 20180371544
    Abstract: Disclosed are compositions and methods related to the use of unique molecular identifiers (UMIs) to improve the error-correction capability of third generation sequencing and similar approaches that involve high precision reading of long segments of single DNA molecules.
    Type: Application
    Filed: December 30, 2016
    Publication date: December 27, 2018
    Inventors: Konstantin Khrapko, Sfia Annis, Jonathan Lee Tilly, Dori Cousins Woods, Slava Epstein
  • METHODS FOR GROWTH AND MATURATION OF OVARIAN FOLLICLES
    Publication number: 20180289748
    Abstract: The present technology provides for methods for generation and isolation of granulosa cells and/or granulosa cell precursors from multi-potent cells, wherein the granulosa cells and/or granulosa cell precursors are useful in methods for growth and maturation of follicles or follicle-like structures. Additionally, the present technology also provides for methods of increasing steroidal hormones in a subject in need thereof.
    Type: Application
    Filed: March 27, 2014
    Publication date: October 11, 2018
    Inventors: Jonathan Lee Tilly, Dori Cousins Woods
  • Isolated Populations of Female Germline Stem Cells and Cell Preparations and Compositions Thereof
    Publication number: 20180200305
    Abstract: The present invention relates to female germline stem cells and their progenitors, methods of isolation thereof, and methods of use thereof.
    Type: Application
    Filed: March 9, 2018
    Publication date: July 19, 2018
    Inventors: Jonathan Lee Tilly, Joshua Johnson
  • Isolated populations of female germline stem cells and cell preparations and compositions thereof
    Patent number: 9962411
    Abstract: The present invention relates to female germline stem cells and their progenitors, methods of isolation thereof, and methods of use thereof.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: May 8, 2018
    Assignee: The General Hospital Corporation
    Inventors: Jonathan Lee Tilly, Joshua Johnson
  • Compositions and Methods for Enhancing Bioenergetic Status in Female Germ Cells
    Publication number: 20180100166
    Abstract: Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.
    Type: Application
    Filed: November 17, 2017
    Publication date: April 12, 2018
    Inventors: Jonathan Lee Tilly, David A. Sinclair
  • METHODS FOR GROWTH AND MATURATION OF OVARIAN FOLLICLES
    Publication number: 20170087192
    Abstract: The present technology provides for methods for generation and isolation of granulosa cells and/or granulosa cell precursors from multi-potent cells, wherein the granulosa cells and/or granulosa cell precursors are useful in methods for growth and maturation of follicles or follicle-like structures. Additionally, the present technology also provides for methods of increasing steroidal hormones in a subject in need thereof.
    Type: Application
    Filed: March 27, 2014
    Publication date: March 30, 2017
    Inventors: Jonathan Lee Tilly, Dori Cousins Woods
  • Compositions and Methods for Enhancing Bioenergetic Status in Female Germ Cells
    Publication number: 20160024527
    Abstract: Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.
    Type: Application
    Filed: February 26, 2015
    Publication date: January 28, 2016
    Inventors: Jonathan Lee Tilly, David A Sinclair
  • Compositions and Methods for Autologous Germline Mitochondrial Energy Transfer
    Publication number: 20150353887
    Abstract: Oogonial stem cell (OSC)-derived compositions, such as nuclear free cytoplasm or isolated mitochondria, and uses of OSC-derived compositions in autologous fertility-enhancing procedures are described.
    Type: Application
    Filed: August 11, 2015
    Publication date: December 10, 2015
    Inventors: Jonathan Lee Tilly, Dori C. Woods
  • ISOLATED POPULATIONS OF FEMALE GERMLINE STEM CELLS AND CELL PREPARATIONS AND COMPOSITIONS THEREOF
    Publication number: 20140308253
    Abstract: The present invention relates to female germline stem cells and their progenitors, methods of isolation thereof, and methods of use thereof.
    Type: Application
    Filed: June 25, 2014
    Publication date: October 16, 2014
    Inventors: Jonathan Lee Tilly, Joshua Johnson
  • Isolated populations of female germline stem cells and cell preparations and compositions thereof
    Publication number: 20140294776
    Abstract: The present invention relates to female germline stem cells and their progenitors, methods of isolation thereof, and methods of use thereof.
    Type: Application
    Filed: January 21, 2014
    Publication date: October 2, 2014
    Inventors: Jonathan Lee Tilly, Joshua Johnson
  • Method for obtaining female germline stem cells and uses thereof
    Patent number: 8652840
    Abstract: The present invention relates to female germline stem cells and their progenitors, methods of isolation thereof, and methods of use thereof.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: February 18, 2014
    Assignee: The General Hospital Corporation
    Inventors: Jonathan Lee Tilly, Joshua Johnson
  • Compositions and methods for autologous germline mitochondrial energy transfer
    Patent number: 8642329
    Abstract: Oogonial stem cell (OSC)-derived compositions, such as nuclear free cytoplasm or isolated mitochondria, and uses of OSC-derived compositions in autologous fertility-enhancing procedures are described.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: February 4, 2014
    Assignee: The General Hospital Corporation
    Inventors: Jonathan Lee Tilly, Dori C. Woods
  • COMPOSITIONS COMPRISING FEMALE GERMLINE STEM CELLS AND METHODS OF USE THEREOF
    Publication number: 20120087898
    Abstract: The present invention relates to female germline stem cells and their progenitors, methods of isolation thereof, and methods of use thereof.
    Type: Application
    Filed: April 20, 2011
    Publication date: April 12, 2012
    Applicant: The General Hospital Corporation
    Inventors: Jonathan Lee Tilly, Joshua Johnson