Abstract: A method for designing a chimeric antigen receptor (CAR), comprising: a) defining a training set of CAR sequences wherein each training CAR is associated with one or more properties; b) defining one or more objectives, each of the one or more objectives defining a desired property of a CAR; c) training a computational model using the training set of the one or more training CAR sequences to provide a trained computational model; d) using the computational model to provide at least one output CAR sequence, and wherein the at least one output CAR sequence is determined based on the one or more objectives. Methods of training a computational model for designing a chimeric antigen receptor (CAR), the trained model provided by such method, along with a CAR sequence output, the CAR encoded by the output CAR sequence and a cell expressing said CAR are also provided.