Patents by Inventor Jonathan Lewin

Jonathan Lewin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190330167
    Abstract: The present invention relates to novel compounds which active HIV expression in latently infected cells. More particularly, the invention relates to pharmaceutical compositions comprising the novel compounds and their use in activating HIV expression in latently infected cells. Further still, the invention relates to pharmaceutical compositions comprising the novel compounds in combination with anti-HIV therapy compounds and their use in treating HIV infection in both animals and humans. The invention further provides means for preparing the compounds.
    Type: Application
    Filed: June 21, 2017
    Publication date: October 31, 2019
    Inventors: Brad SLEEBS, Damian Francis John PURCELL, Jonathan JACOBSON, Sharon LEWIN, William NGUYEN
  • Patent number: 10459045
    Abstract: Sterile RF coil arrangements for use in magnetic resonance imaging are provided. The sterile coil arrangements can be formed by spraying or coating a curable liquid onto an RF coil housing and allowing the liquid to cure or dry to form a continuous sterile layer on the coil housing. The thickness of the sterile layer can be between 100 and 1000 micrometers. The curable liquid can include an antimicrobial or antibacterial agent, such as silver ions or triclosan, to better maintain sterility of the coil arrangement. The curable liquid can be selected such that it adheres to the housing when cured and is also removable without leaving residue behind.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: October 29, 2019
    Assignees: Siemens Healthcare GmbH, The Johns Hopkins University
    Inventors: Arne Hengerer, Eva Rothgang, Lars Lauer, Jonathan Lewin, Jan Fritz, Clifford Weiss, Katarzyna J. Macura, Paul Bottomley, Wesley David Gilson
  • Patent number: 10209325
    Abstract: A configurable coil arrangement for use with MRI-guided procedures is provided that facilitates optimal imaging for both pre-procedure planning and imaging of the target sites during the procedure. The coil arrangement includes a plurality of connected coil elements. Spacers connecting the coil elements can be adjustable and/or deformable to provide one or more openings in the coil arrangement of optimal size for accessing the subject within the imaged region. Individual coil elements can also be removed to provide access openings during such procedures, or left in the array for improved pre- and post-procedure image quality. The MRI system can be configured to detect configurations of the coil arrangement and modify imaging parameters to optimize image quality.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: February 19, 2019
    Assignees: Siemens Healthcare GmbH, The Johns Hopkins University
    Inventors: Eva Rothgang, Volker Matschl, Arne Hengerer, Lars Lauer, Wesley David Gilson, Jonathan Lewin, Jan Fritz, Clifford Weiss, Katarzyna Macura, Paul Bottomley
  • Patent number: 10180469
    Abstract: A magnetic resonance imaging system and method are provided that include user control of certain functions using physical gestures, such as hand motions or the like. The gesture control aspects can include one or more cameras, and a processor configured to detect and recognize gestures corresponding to predetermined commands and to provide signals to execute the commands. A verification switch, such as a foot switch, can be included to improve safety and reliability of the gesture control aspects. This switch can be used to activate the gesture detection aspects and/or to confirm a recognized gesture command prior to its execution.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: January 15, 2019
    Assignees: Siemens Healthcare GmbH, The John Hopkins University
    Inventors: Arne Hengerer, Eva Rothgang, Lars Lauer, Jonathan Lewin, Wesley David Gilson, Jan Fritz, Clifford R. Weiss, Katarzyna J. Macura, Paul A. Bottomley
  • Publication number: 20170276742
    Abstract: Sterile RF coil arrangements for use in magnetic resonance imaging are provided. The sterile coil arrangements can be formed by spraying or coating a curable liquid onto an RF coil housing and allowing the liquid to cure or dry to form a continuous sterile layer on the coil housing. The thickness of the sterile layer can be between 100 and 1000 micrometers. The curable liquid can include an antimicrobial or antibacterial agent, such as silver ions or triclosan, to better maintain sterility of the coil arrangement. The curable liquid can be selected such that it adheres to the housing when cured and is also removable without leaving residue behind.
    Type: Application
    Filed: March 28, 2016
    Publication date: September 28, 2017
    Inventors: Arne Hengerer, Eva Rothgang, Lars Lauer, Jonathan Lewin, Jan Fritz, Clifford Weiss, Katarzyna J. Macura, Paul Bottomley, Wesley David Gilson
  • Publication number: 20170248666
    Abstract: A configurable coil arrangement for use with MRI-guided procedures is provided that facilitates optimal imaging for both pre-procedure planning and imaging of the target sites during the procedure. The coil arrangement includes a plurality of connected coil elements. Spacers connecting the coil elements can be adjustable and/or deformable to provide one or more openings in the coil arrangement of optimal size for accessing the subject within the imaged region. Individual coil elements can also be removed to provide access openings during such procedures, or left in the array for improved pre- and post-procedure image quality. The MRI system can be configured to detect configurations of the coil arrangement and modify imaging parameters to optimize image quality.
    Type: Application
    Filed: February 29, 2016
    Publication date: August 31, 2017
    Inventors: Eva Rothgang, Volker Matschl, Arne Hengerer, Lars Lauer, Wesley David Gilson, Jonathan Lewin, Jan Fritz, Clifford Weiss, Katarzyna Macura, Paul Bottomley
  • Publication number: 20170123030
    Abstract: A magnetic resonance imaging system and method are provided that include user control of certain functions using physical gestures, such as hand motions or the like. The gesture control aspects can include one or more cameras, and a processor configured to detect and recognize gestures corresponding to predetermined commands and to provide signals to execute the commands. A verification switch, such as a foot switch, can be included to improve safety and reliability of the gesture control aspects. This switch can be used to activate the gesture detection aspects and/or to confirm a recognized gesture command prior to its execution.
    Type: Application
    Filed: October 28, 2015
    Publication date: May 4, 2017
    Inventors: Arne Hengerer, Eva Rothgang, Lars Lauer, Jonathan Lewin, Wesley David Gilson, Jan Fritz, Clifford R. Weiss, Katarzyna J. Macura, Paul A. Bottomley
  • Patent number: 9031634
    Abstract: A new and improved method for tracking and/or spatial localization of an invasive device in Magnetic Resonance Imaging (MRI) is provided. The invention includes providing an invasive device including a marker having a chemically shifted signal source with a resonant frequency different from the chemical species of the subject to be imaged, applying a pulse sequence, detecting the resulting RF magnetic resonance signals, and determining the 3D coordinates of the marker. The invention also includes generating scan planes and reconstructing an image from the detected signals to generate an image having the marker contrasted from the subject. The invasive device includes a marker having a chemically shifted signal source which has a resonant frequency different from the chemical species of the subject to be imaged for use in tracking the device during imaging.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: May 12, 2015
    Inventors: Christopher Flask, Jonathan Lewin, Daniel Elgort, Ken Pin Wang, Eddy Wong, Jeffrey Duerk
  • Publication number: 20070253899
    Abstract: The invention relates to micelles that are elaborated with functionality useful for imaging and/or selectively targeting tissue, e.g., in the delivery of hydrophobic agents.
    Type: Application
    Filed: June 2, 2005
    Publication date: November 1, 2007
    Inventors: Hua Ai, Jeffrey Duerk, Chris Flask, Jinming Gao, Jonathan Lewin, Xintao Shuai, Brent Weinberg
  • Publication number: 20060181275
    Abstract: Systems, methodologies, media, and other embodiments associated with a block-by-block off-resonance frequency estimation method are described. One exemplary method embodiment includes calculating a field map from local B0 off resonance frequency estimates. The example method may also include performing water-fat decomposition and signal de-blurring based on the calculated map.
    Type: Application
    Filed: February 15, 2005
    Publication date: August 17, 2006
    Applicant: Case Western Reserve University
    Inventors: Hisamoto Moriguchi, Jonathan Lewin, Jeffrey Duerk
  • Publication number: 20060184003
    Abstract: Systems, methodologies, media, and other embodiments associated with facilitating intra-procedurally determining the position of an internal anatomical target location using an externally measurable parameter are described. One exemplary method embodiment includes pre-procedurally correlating internal anatomy motion with external marker motion. The example method may also include providing computer graphics to an augmented reality system during a percutaneous procedure to facilitate image guiding an interventional device with respect to the internal anatomy.
    Type: Application
    Filed: February 3, 2005
    Publication date: August 17, 2006
    Inventors: Jonathan Lewin, Daniel Elgort, Frank Wacker, Frank Sauer, Ali Khamene, Jeffrey Duerk
  • Publication number: 20060173277
    Abstract: Systems, methodologies, media, and other embodiments associated with automatically adapting MRI controlling parameters are described. One exemplary method embodiment includes configuring an MRI apparatus to acquire MR signal data using a non-rectilinear trajectory. The example method may also include acquiring MR signals, transforming the MR signals into image data, and selectively adapting the MRI controlling parameters based, at least in part, on information associated with the MR signals.
    Type: Application
    Filed: February 3, 2005
    Publication date: August 3, 2006
    Inventors: Daniel Elgort, Eddy Wong, Claudia Hillenbrand, Jonathan Lewin, Jeffrey Duerk
  • Publication number: 20060116574
    Abstract: Extended-coverage magnetic resonance imaging coils with optimized homogeneity in longitudinal sensitivity are described. One exemplary coil includes four elements, where two of the elements are opposed-solenoid imaging elements and two of the elements are single loop imaging elements.
    Type: Application
    Filed: November 30, 2004
    Publication date: June 1, 2006
    Inventors: Eddy Wong, Claudia Hillenbrand, Jonathan Lewin, Jeffrey Duerk
  • Publication number: 20060116570
    Abstract: A method and system for improving image quality by correcting errors introduced by rotational motion of an object being imaged is provided. The object is associated with a fiducial mark. The method provides a computer executable methodology for detecting a rotation and selectively reordering, deleting and/or reacquiring projection data.
    Type: Application
    Filed: September 13, 2005
    Publication date: June 1, 2006
    Inventors: Jeffrey Duerk, Ajit Shankaranarayanan, Michael Wendt, Jonathan Lewin
  • Publication number: 20050074152
    Abstract: Methods are described for efficient reconstruction of MRI data. In one practice, new reconstruction algorithms for non-uniformly sampled k-space data are presented. In the disclosed algorithms, Iterative Next-Neighbor re-Gridding (INNG) and Block INNG (BINNG), iterative procedures are performed using larger rescaled matrices than the target grid matrix In BINNG algorithm, the sampled k-space region is partitioned into several blocks and the INNG algorithm is applied to each block. In another practice, a novel partial spiral reconstruction (PFSR) uses an estimated phase map from a low-resolution image reconstructed from the central k-space data and performs iterations, similar to the iterative procedures with INNG, with an imposed phase constraint. According to yet another practice, an off-resonance correction is performed on matrices that are smaller than the full image matrix. All these methods reduce the computational costs while rendering high-quality reconstructed images.
    Type: Application
    Filed: May 5, 2004
    Publication date: April 7, 2005
    Applicant: Case Western Reserve University
    Inventors: Jonathan Lewin, Hisamoto Moriguchi, Jeffrey Duerk, Brian Dale
  • Publication number: 20050057249
    Abstract: A magnetic resonance data acquisition method includes designating a plurality of parameters that are representative of conditions for acquiring data from a magnetic resonance apparatus, at least one of the parameters being variable; designating at least one objective function measuring the quality of the acquired magnetic resonance data; optimizing the at least one objective function using an optimization algorithm to find at least one set of optimum values for the parameters characterizing data acquisition; configuring the magnetic resonance apparatus with the parameters determined above, configuring by one set of the optimum values of the parameters, and instructing a magnetic resonance imaging apparatus to apply the field to the target of the data acquisition to acquire the data.
    Type: Application
    Filed: May 17, 2004
    Publication date: March 17, 2005
    Inventors: Brian Dale, Jeffrey Duerk, Jonathan Lewin
  • Publication number: 20050054914
    Abstract: A probe suitable for attachment to, or incorporation in, a medical interventional device, such as a catheter, and which may be employed for tracking, imaging, or both, includes a first material having an MR resonance frequency distinct from a resonance frequency of a second material adjacent to the first material. The probe may include one or more coils, or it may be wireless, that is, it may have no coils. Some probe configurations are directed at tracking or imaging of vascular vessels or tissue, and configurations allow both tracking and imaging.
    Type: Application
    Filed: May 5, 2004
    Publication date: March 10, 2005
    Inventors: Jeffrey Duerk, Daniel Elgort, Chris Flask, Claudia Hillenbrand, Jonathan Lewin, Eddy Wong
  • Publication number: 20050054913
    Abstract: A method of automatically adjusting at least one MR image parameter for an interventional procedure includes adaptively tracking an MR micro-coil catheter and automatically updating an imaging scan plane's position and orientation, as well as other features including, but not limited to, field-of-view, resolution, temporal resolution, slice thickness, tip angle, and TE. The disclosed system provides a more natural interface for a physician operating the MR scanner during an interventional procedure. The scanner can react to changes in the clinical environment and automatically adjust a number of image parameters. For example, during catheter insertion, images are acquired at lower resolutions, and possibly larger fields of view, to help facilitate faster updates and tracking. Once the catheter reaches a target area in the tissue and its motion slows, an MR image of higher resolution, and possibly lower field of view, is acquired.
    Type: Application
    Filed: May 5, 2004
    Publication date: March 10, 2005
    Inventors: Jeffrey Duerk, Daniel Elgort, Chris Flask, Claudia Hillenbrand, Jonathan Lewin, Frank Wacker, Eddy Wong
  • Publication number: 20050033153
    Abstract: Spiral imaging has recently gained acceptance for rapid MR data acquisition. One of the main disadvantages of spiral imaging, however, is blurring artifacts due to off-resonance effects. Dixon techniques have been developed as methods of water-fat signal decomposition in rectilinear sampling schemes, and they can produce unequivocal water-fat signal decomposition even in the presence of B0 inhomogeneity. Three-point and two-point Dixon techniques can be extended to conventional spiral and variable-density spiral data acquisitions for unambiguous water-fat decomposition with off-resonance blurring correction. In the spiral three-point Dixon technique, water-fat signal decomposition and image deblurring are performed based on the frequency maps that are directly derived from the acquired images. In the spiral two-point Dixon technique, several predetermined frequencies are tested to create a frequency map.
    Type: Application
    Filed: April 26, 2004
    Publication date: February 10, 2005
    Applicant: Case Westem Reserve University
    Inventors: Hisamoto Moriguchi, Jonathan Lewin, Jeffrey Duerk
  • Publication number: 20050017717
    Abstract: A method of chemical species suppression for MRI imaging of a scanned object region including acquiring K space data at a first TE, acquiring K space data at a second TE, reconstructing images having off resonance effects, estimating off resonance effects at locations throughout the reconstructed image, and determining the first and second chemical species signals at image locations of the scanned object from the acquired signals and correcting for blurring resulting from off resonance effects due to B0 inhomogeneity.
    Type: Application
    Filed: March 22, 2004
    Publication date: January 27, 2005
    Inventors: Jeffrey Duerk, Jonathan Lewin, Hisamoto Moriguchi