Abstract: An ophthalmic device includes an optic including an optic axis and a closed-loop haptic structure coupled to the optic via a frame surrounding the optic, the closed-loop haptic structure including a closed loop extending from first and second attachment points to the frame. The closed loop includes a first hinge and a second hinge. The first hinge has a first section having a first component extending in a first angular direction, a second section having a second component extending in a second angular direction opposite to the first angular direction, and a first connecting section between the first section and the second section. The second hinge has a third section having a third component extending in the second angular direction, a fourth section having a fourth component extending in the first angular direction, the fourth section being connected to the second section to form the closed loop.

Abstract: Velocity tomography using time lags of wave equation migration is disclosed. Seismic tomography is a technique for imaging the subsurface of the Earth with seismic waves by generated a migration velocity model from a multitude of observations using combinations of source and receiver locations. The migration velocity model may be updated in order to reduce depth differences of reflection events (also called residual depth errors (RDE)). Direct measurement of RDE may be difficult in certain complex subsurface areas. In such areas, the RDE may be reconstructed based on time lags of wave equation migration and then used to update the migration velocity model. In particular, the RDE may be directly reconstructed from the time lags of wave equation migration, such as based on a direct relation between RDE and the time lags.

Abstract: A self-piercing riveting (SPR) system includes a top sheet and a bottom sheet. The top sheet is layered above the bottom sheet and are disposed between a die and a blank holder. The SPR system further includes a barrier disposed between the bottom sheet and the die, wherein the barrier is configured to reduce stress concentrations during formation of a joint between the top sheet and the bottom sheet. The barrier may has a thickness between 0.8 mm and 1.0 mm and is made from a cold formed or a dual phase steel alloy.

Abstract: An ultrasound transducer device made by a process that includes the steps of forming depositing a first layer on a substrate, depositing a second layer on the first layer, patterning the second layer at a region corresponding to a location of a transducer cavity, depositing a third layer that refills regions created by patterning the second layer, planarizing the third layer to a top surface of the second layer, removing the second layer, conformally depositing a fourth layer over the first layer and the third layer, defining the transducer cavity in a support layer formed over the fourth layer; and bonding a membrane to the support layer.

Abstract: An input device that includes multiple electrodes disposed in a sensing region of the input device and a sensing circuit coupled to a first electrode and configured to detect an input object proximate the sensing region. The sensing circuit includes an amplifier having an inverting input coupled to the first electrode, a non-inverting input coupled to a drive signal, and an output generating a resulting signal. The sensing circuit includes a feedback capacitor coupled between the output and the inverting input of the amplifier. The drive signal comprises a first sinusoidal signal having a first operating frequency and a second sinusoidal signal having a second operating frequency. The resulting signal is determined by the feedback capacitor and a capacitance of the first electrode caused by the input object. The resulting signal generates a sensing signal on the first electrode.

Abstract: Inserts can be formed with elution characteristics to cause the inserts to elute an antimicrobial agent when subject to a fluid within a medical device. An insert can be formed with a desired geometry to allow the insert to be compression fit within a medical device to prevent the insert from moving or becoming dislodged once inserted into the medical device. The material may also be hygroscopic so that the insert swells when subject to a fluid thereby enhancing the compression fit of the device within the medical device. In some cases, the material can be reinforced using an internal structure. Inserts can be formed in many ways including by casting, thermoforming, or extrusion. In some cases, the inserts can be formed using a peel-away sleeve or material. The peel-away sleeves can be formed of a non-sticky material which facilitates removal of the inserts once the inserts have cured.

Abstract: Glass articles including a glass laminate substrate having a plurality of flow channels formed therein are provided. The glass laminate substrate includes a first glass layer and a second glass layer fused together. In various embodiments, at least 80% of a total area of a floor of each of the flow channels has a local surface flatness of less than 100 nm/mm2, measured along a length and width of the floor of each of the plurality of flow channels Such glass articles are manufactured using a method including contacting a first portion of the first glass layer with a first etchant for a first etch time to at least partially form flow channels in the glass substrate and contacting the flow channels with a second etchant for a second etch time to flatten a floor of each of the flow channels.

Abstract: The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (SuS) enzymes, polypeptides having SuS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the GT enzymes and methods of using the engineered GT enzymes to make products with ?-glucose linkages. The present invention further provides compositions and methods for the production of rebaudiosides (e.g., rebaudioside M, rebaudioside A, rebaudioside I, and rebaudioside D). The present invention also provides compositions comprising the SuS enzymes and methods of using them. Methods for producing GT and SuS enzymes are also provided.

Abstract: An input device that includes multiple electrodes disposed in a sensing region of the input device and a sensing circuit coupled to a first electrode and configured to detect an input object proximate the sensing region. The sensing circuit includes an amplifier having an inverting input coupled to the first electrode, a non-inverting input coupled to a drive signal, and an output generating a resulting signal. The sensing circuit includes a feedback capacitor coupled between the output and the inverting input of the amplifier. The drive signal comprises a first sinusoidal signal having a first operating frequency and a second sinusoidal signal having a second operating frequency. The resulting signal is determined by the feedback capacitor and a capacitance of the first electrode caused by the input object. The resulting signal generates a sensing signal on the first electrode.

Abstract: A modular mask including a first module including a frame having two or more openings, and an attaching mechanism lining one or more edges of the two or more openings; and a second module including: a mask body having a first attaching element allowing the attaching mechanism to temporarily hold the mask body in place completely covering a first opening of the two or more openings, and a filter component having a second attaching element allowing the attaching mechanism to temporarily hold the filter component in place completely covering a second opening of the two or more openings.

Abstract: A slit lamp microscope of an aspect example includes a scanner and a data processor. The scanner is configured to scan an anterior segment of a subject's eye with slit light to collect a plurality of cross sectional images. The data processor is configured to generate opacity distribution information that represents a distribution of an opaque area in a crystalline lens, based on the plurality of cross sectional images collected by the scanner.

Abstract: Methods and systems for angiographic imaging with optical coherence tomography (OCT) are described using ratio-based and angiographic deviation based calculations. In using these calculations to determine motion, arbitrary interframe permutations may be used, post- calculated, non-linear results for projection visualization may be averaged, poor matches may be eliminated on an A-line by A-line basis, windowing functions may be used to improve results, partial spectrums may be used when capturing data, and a minimum intensity threshold may be used for determining which pixels to use.

Abstract: An ophthalmologic information processing apparatus includes an acquisition unit, a tissue specifying unit, and a specifying unit. The acquisition unit is configured to acquire a tomographic image of a subject's eye. The tissue specifying unit is configured to acquire first shape data representing shape of a tissue of the subject's eye by performing segmentation processing on each of a plurality of tomographic images acquired by the acquisition unit. The specifying unit is configured to obtain second shape data representing shape of the tissue based on the plurality of first shape data acquired by the tissue specifying unit.

Abstract: A slit lamp microscope of some aspect examples includes a scanner and a rendering processor. The scanner is configured to scan an anterior segment of a subject's eye with slit light to collect a plurality of cross sectional images. The rendering processor is configured to apply rendering to a three dimensional image created from the plurality of cross sectional images.

Abstract: A multimodal imaging system and method is capable of taking fundus images, automatically identifying regions of interest (ROIs) of the eye from the fundus images, and performing OCT imaging in the identified ROIs, where the OCT images can provide clinically relevant information for screening purposes. By automatically identifying the ROIs, expert intervention is not required to perform specialized OCT imaging and thus, such imaging and analysis can be provided at more facilities and for more subjects for a lower cost.

Abstract: An ophthalmic apparatus includes an acquiring unit, an OCT unit, an analyzer, and a calculator. The acquiring unit is configured to acquire a dioptric power in a first region including a fovea of a subject's eye. The OCT unit is configured to acquire OCT data of a fundus of the subject's eye using optical coherence tomography. The analyzer is configured to specify a shape of the fundus by analyzing the OCT data. The calculator is configured to calculate a dioptric power in a peripheral region of the first region of the fundus based on the dioptric power in the first region and the shape of the fundus.

Abstract: An ophthalmologic apparatus of embodiments includes an OCT unit, an acquisition unit, and a specifying unit. The OCT unit is configured to acquire a tomographic image of a subject's eye using optical coherence tomography. The acquisition unit is configured to acquire a front image of the subject's eye. The specifying unit is configured to specify shape of a tissue of the subject's eye based on the tomographic image acquired by the OCT unit and the front image acquired by the acquisition unit.

Abstract: An ophthalmologic information processing apparatus includes an acquisition unit, a tissue specifying unit, and a specifying unit. The acquisition unit is configured to acquire a tomographic image of a subject's eye formed based on scan data acquired using an optical system for performing optical coherence tomography on the subject's eye. The tissue specifying unit is configured to acquire first shape data representing shape of a tissue of the subject's eye by performing segmentation processing on the tomographic image. The specifying unit is configured to specify a low sensitivity component having a small variation with respect to a change in a position of the optical system with respect to the subject's eye from the first shape data, and to obtain second shape data representing shape of the tissue based on the specified low sensitivity component.

Abstract: A multimodal imaging system and method is capable of taking fundus images, automatically identifying regions of interest (ROIs) of the eye from the fundus images, and performing OCT imaging in the identified ROIs, where the OCT images can provide clinically relevant information for screening purposes. By automatically identifying the ROIs, expert intervention is not required to perform specialized OCT imaging and thus, such imaging and analysis can be provided at more facilities and for more subjects for a lower cost.

Abstract: Velocity tomography using time lags of wave equation migration is disclosed. Seismic tomography is a technique for imaging the subsurface of the Earth with seismic waves by generated a migration velocity model from a multitude of observations using combinations of source and receiver locations. The migration velocity model may be updated in order to reduce depth differences of reflection events (also called residual depth errors (RDE)). Direct measurement of RDE may be difficult in certain complex subsurface areas. In such areas, the RDE may be reconstructed based on time lags of wave equation migration and then used to update the migration velocity model. In particular, the RDE may be directly reconstructed from the time lags of wave equation migration, such as based on a direct relation between RDE and the time lags.