Patents by Inventor Jonathan M. Barasch

Jonathan M. Barasch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR THE EARLY DETECTION OF RENAL INJURY
    Publication number: 20090142774
    Abstract: A method and kit for detecting the immediate or early onset of renal disease and injury, including renal tubular cell injury, utilizing NGAL as an immediate or early on-set biomarker in a sample of blood serum. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the blood serum following renal tubule cell injury. NGAL protein expression is detected predominantly in proximal tubule cells, in a punctuate cytoplasmic distribution reminiscent of a secreted protein. The appearance NGAL in the serum is related to the dose and duration of renal ischemia and nephrotoxemia, and is diagnostic of renal tubule cell injury and renal failure. NGAL detection is also a useful marker for monitoring the nephrotoxic side effects of drugs or other therapeutic agents.
    Type: Application
    Filed: December 5, 2008
    Publication date: June 4, 2009
    Inventors: Prasad Devarajan, Jonathan M. Barasch
  • METHOD AND KIT FOR DETECTING THE EARLY ONSET OF RENAL TUBULAR CELL INJURY
    Publication number: 20090123941
    Abstract: A method and kit for detecting the early onset of renal tubular cell injury, utilizing NGAL as an early urinary biomarker. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine following renal tubule cell injury. NGAL protein expression is detected predominantly in proximal tubule cells, in a punctate cytoplasmic distribution reminiscent of a secreted protein. The appearance NGAL in the urine is related to the dose and duration of renal ischemia and nephrotoxemia, and is diagnostic of renal tubule cell injury and renal failure. NGAL detection is also a useful marker for monitoring the nephrotoxic side effects of drugs or other therapeutic agents.
    Type: Application
    Filed: December 5, 2008
    Publication date: May 14, 2009
    Inventors: Prasad Devarajan, Jonathan M. Barasch
  • Method of inducing formation of kidney epithelia from mesenchymal precursors
    Patent number: 7022666
    Abstract: This invention provides methods of using a gp130 receptor ligand, e.g. leukemia inhibitory factor, to induce the formation of kidney epithelia, to treat subjects suffering from kidney failure, and to preserve kidneys for transplantation.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: April 4, 2006
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jonathan M. Barasch, Juan A. Oliver, Jun Yang
  • Method and kit for detecting the early onset of renal tubular cell injury
    Publication number: 20040219603
    Abstract: A method and kit for detecting the early onset of renal tubular cell injury, utilizing NGAL as an early urinary biomarker. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine following renal tubule cell injury. NGAL protein expression is detected predominantly in proximal tubule cells, in a punctate cytoplasmic distribution reminiscent of a secreted protein. The appearance NGAL in the urine is related to the dose and duration of renal ischemia and nephrotoxemia, and is diagnostic of renal tubule cell injury and renal failure. NGAL detection is also a useful marker for monitoring the nephrotoxic side effects of drugs or other therapeutic agents.
    Type: Application
    Filed: March 26, 2004
    Publication date: November 4, 2004
    Inventors: Prasad Devarajan, Jonathan M. Barasch
  • Method of inducing formation of kidney epithelia from mesenchymal precursors
    Patent number: 6423681
    Abstract: This invention provides methods of using a gpl3O receptor ligand, e.g. leukemia inhibitory factor, to induce the formation of kidney epithelia, to treat subjects suffering from kidney failure, and to preserve kidneys for transplantation.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: July 23, 2002
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Jonathan M. Barasch, Juan A. Oliver, Jun Yang